Submerged Eutectic-Assisted, Solvent-Free Mechanochemical Formation of a Propranolol Salt and Its Other Multicomponent Solids

Salt preparation via a solid-state reaction offers a solution to challenges posed by current pharmaceutical research, which include combining development of novel forms of active pharmaceutical ingredients with greener, sustainable synthesis. This work investigated in detail the mechanism of salt formation between propranolol (PRO) and capric acid (CAP) and explored the solid eutectic phases comprising this salt, propranolol caprate (PRC). The salt structure was solved by X-ray diffraction, and the properties in the crystalline and supercooled states were fully characterised using thermal analysis, nuclear magnetic resonance, Fourier-transform infrared spectroscopy and broadband dielectric spectroscopy (BDS). PRC forms via a submerged eutectic phase composed of PRO and CAP, below room temperature, by mechanochemistry without an extra input of energy. Two other solid eutectic phases are composed of PRC and either CAP or PRO, at 0.28 and 0.82 mol fraction of PRO, respectively. BDS indicated that the supercooled PRC has ionic character, whereas the supercooled PRC-PRO eutectic had predominantly non-ionic properties despite comprising the salt. In conclusion, knowledge of the mechanism of formation of multicomponent systems can help in designing more sustainable pharmaceutical processes.

Sub-areas in steep rock salt formations – what do we know about the geological composition of North German salt structures?

Suitable host rocks for a repository for high-level radioactive waste (HLW) in Germany include not only clay and crystalline rocks but also rock salt formations in so-called flat and steep bedding (StandAG, 2017). Favourable repository relevant properties of rock salt are, e.g. the high heat conductivity, low porosity and permeability, and its viscoplastic deformation behaviour. Thicker salt deposits can be attributed to the formation of approx. 700 salt structures that have formed under various geological conditions in the North German Basin (NGB) over the last 250 million years. According to their shape and genesis, salt structures are classified as salt pillows (considered as flat bedding) or salt diapirs (steep bedding). Out of a total of 74 sub-areas in rock salt, 60 sub-areas in salt diapirs consisting of Permian evaporates were identified within the first phase of the German site selection procedure (BGE, 2020). At the current stage of the site selection process, a conservative approach has been adopted and the internal structure of the salt structures have not yet been taken into account for further classification of the identified sub-areas. However, the interior of the salt structures not only consists of rock salt but also of varying proportions of clay, carbonate and anhydrite rocks, as well as potassium salts formed by progressive evaporation of marine brines. Multi-phase salt tectonics has led to the folding of these differently composed layers and to complex internal structures. Therefore, detailed knowledge of the salt structure compositions is necessary to identify suitable rock salt areas for the designation of the containment providing rock zone. As a result of decades of research through extensive salt and potash mining, cavern storage and exploration for final waste disposal, Permian salt rocks represent a well-studied host rock in Germany. The use of different exploration methods and multidisciplinary data evaluation have led to a comprehensive understanding of the internal composition of some well-studied salt structures. Systematic studies have shown that several factors have influenced the formation of salt structures as well as their external shapes, sizes, and spatial distribution (e.g., Pollok et al., 2020). Furthermore, the amount and distribution of suitable host rocks varies greatly in different salt structures and is closely related to their internal structure. Since the interior of salt structures has not been considered in the site selection process so far, a classification of salt structures (or sub-areas) into certain types with varying internal composition and complexity is presented. By examining their lithofacial composition, genesis, and structural geological position within the basin, it is possible to narrow down these types to specific areas in the NGB. Without the acquisition of additional exploration data in this phase of the site selection process, this salt structure classification provides important data for the legally demanded assessment of the overall favourable geological situation.

Study of the Overflow Transport of the Nordic Sea

Changes in the climate system over recent decades have had profound impacts on the mean state and variability of ocean circulation, while the Nordic Sea overflow has remained stable in volume transport during the last two decades. The changes of the overflow flux depend on the pressure difference at the depth of the overflow outlet on both sides of the Greenland-Scotland Ridge (GSR). Combining satellite altimeter data and the reanalysis hydrological data, the analysis found that the barotropic pressure difference and baroclinic pressure difference on both sides of the GSR had a good negative correlation from 1993 to 2015. Both are caused by changes in the properties of the upper water, and the total pressure difference has no trend change. The weakening of deep convection can only change the temperature and salt structure of the Nordic Sea, but cannot reduce the mass of the water column. Therefore, the stable pressure difference drives a stable overflow. The overflow water storage in the Nordic Sea is decreasing, which may be caused by the reduction of local overflow water production and the constant overflow flux. When the upper interface of the overflow water body in the Nordic Sea is close to or below the outlet depth, the overflow is likely to greatly slow down or even experience a hiatus in the future, which deserves more attention.