Relationship between BMP2/9 Levels and Spinal Function and Quality of Life in Patients with Severe Scoliosis after PVCR

Objective. To explore the relationship between (bone fusion associated protein) bone morphogenetic protein (BMP)2 and BMP9 and spinal function and quality of life in patients with severe scoliosis after posterior vertebral column resection (PVCR). Methods. 78 cases of severe scoliosis treated with PVCR surgery in our hospital from January 2015 to April 2018 were selected and set as the observation group, and 80 health examiners in the same period were selected and set as the control group. The ELISA method was used to detect the levels of BMP2 and BMP9 in the two groups. Also, the relationship between the recovery of spinal function, quality of life, and serum BMP2 and BMP9 in the observation group was analyzed. The receiver operating characteristic curve was used to evaluate the predictive value of BMP2 and BMP9 for complications after PVCR. Results. One month after PVCR, the serum BMP2 and BMP9 levels of patients with severe scoliosis were higher than those of healthy people P < 0.05 . One year after PVCR, Pearson correlation analysis showed that serum levels of BMP2 and BMP9 in patients with scoliosis were positively correlated with ODI scores (r = 0.778, P < 0.001 ; r = 0.746, P < 0.001 ), SRS-22 scores (r = 0.758, P < 0.001 ; r = 0.722, P < 0.001 ), and Cobb angle correction rate (r = 0.838, P < 0.001 ; r = 0.802, P < 0.001 ). Conclusion. The levels of BMP2 and BMP9 of patients with scoliosis after PVCR are higher than those of healthy people. After 1-year follow-up, the patients’ serum BMP2 and BMP9 levels were positively correlated with spinal function recovery, quality of life, and surgical efficacy. Among them, BMP2 and BMP9 had the highest correlation with PVCR surgical efficacy. Paying attention to the serum BMP2 and BMP9 levels of patients with scoliosis has certain clinical significance.

Reliability and validity of the novel self-reported spine functional scale (SSFS) in healthy participants

Objectives To develop the novel self-reported spine functional scale (SSFS) and conduct reliability and validity analysis, so that the public can better understand their own spine function in a more simple and scientific way, so as to effectively prevent spinal disorders and improve the quality of life through targeted rehabilitation therapeutic measures. Methods This study was approved by an institutional review board, and all subjects gave informed consent to participate. Results (1) Using Spearman correlation analysis to evaluate the content validity, each item was significantly correlated with the total score, and the project design was reasonable. The exploratory factor analysis method is used to evaluate the structural validity of the scale, and the standing position and the lying position of the posture evaluation can be attributed to the factor 2, which is called posture evaluation: the cervical flexor strength, the flat support, the prone back, and the supine knee. The back arch of the wall and the angel on the wall is attributed to factor 1, called the overall spine function test, and the cumulative contribution rate of the two factors was 46.057%. Confirmatory factor analysis showed that the two-factor model fits well (χ2/df = 2.440, RMSEA = 0.04 < 0.05, GFI = 0.945, AGFI = 0.920, CFI = 0.967, IFI = 0.967, TLI = 0.951, GFI, AGFI, CFI, IFI, and TLI are > 0.90) and the validity is ideal. (2) The test-retest reliability shows that the test-retest reliability of each entry, each dimension, and the total score is greater than 0.5, and the test-retest reliability is high. The Cronbach α coefficient was used to evaluate the overall internal consistency of the scale, α > 0.70, indicating that the scale has high reliability. After deleting each item one by one, the α coefficient is 0.692–0.717, and there is no significant increase. (3) Sex and occupation did not affect the level of spinal function (P > 0.05), and there was interaction. Different BMI levels significantly affected the score of spinal function (P < 0.05). The rate of spinal dysfunction in overweight and obese subjects was significantly higher than the normal group; the overall score of spinal function was worse than the normal group. Discussion The reliability and validity analyses of this study verified the reliability and scientificity of SSFS in the young healthy population. Body weight had a significant influence on SSFS score, and the performance levels were different for the two sexes. Conclusion The novel Self-Reported Spine Functional Scale (SSFS) has high reliability and validity and is applicable to the self-assessment and maintenance of spinal health and the prevention of related spinal disorders in the young healthy population. Body weight has a significant influence on the SSFS score in healthy young people. Overweight and obese males were found to be more likely to have spinal dysfunction, while underweight males displayed poor cervical flexor muscle strength. Underweight females were found to have better overall spinal function and stronger cervical flexor muscle strength.

Reliability and Validity of The Novel Self-Reported Spine Functional Scale (SSFS) in Healthy Participants

Objectives: to develop the novel self-reported spine functional scale (SSFS) and conduct reliability and validity analysis, so that the public can better understand their own spine function in a more simple and scientific way, so as to effectively prevent spinal disorders and improve the quality of life through targeted rehabilitation therapeutic measures.Methods:This study was approved by an institutional review board, and all subjects gave informed consent to participate. Results: (1) Using Spearman correlation analysis to evaluate the content validity, each item was significantly correlated with the total score, and the project design was reasonable. The exploratory factor analysis method is used to evaluate the structural validity of the scale, and the standing position and the lying position of the posture evaluation can be attributed to the factor 2, which is called posture evaluation; the cervical flexor strength, the flat support, the prone back, the supine knee, The back arch of the wall and the angel on the wall attributed to factor 1, called the overall spine function test, and the cumulative contribution rate of the two factors was 46.057%. Confirmatory factor analysis showed that the two-factor model fits well (c2/df=2.440, RMSEA=0.04<0.05, GFI=0.945, AGFI=0.920, CFI=0.967, IFI=0.967, TLI=0.951, GFI, AGFI, CFI , IFI, TLI are >0.90) and the validity is ideal. (2) The test-retest reliability shows that the test-retest reliability of each entry, each dimension and the total score is greater than 0.5, and the test-retest reliability is high. The Cronbach α coefficient was used to evaluate the overall internal consistency of the scale, α>0.70, indicating that the scale has high reliability. After deleting each item one by one, the α coefficient is 0.692-0.717, and there is no significant increase. (3) Sex and occupation did not affect the level of spinal function (P>0.05), and there was interaction. Different BMI levels significantly affected the score of spinal function (P<0.05). The rate of spinal dysfunction in overweight and obese subjects. Significantly higher than the normal group, the overall score of spinal function was worse than the normal group. Conclusion: This scale has good reliability and validity and is suitable for self-assessment of spine function in young people. And overweight and obesity can affect the level of spinal function in young people.

Effects of Clenching Strength on Exercise Performance: Verification Using Spinal Function Assessments

Background: This study aimed to determine the relationship between exercise performance and spinal function based on clenching strength. Hypothesis: Low-intensity clenching contributes to joint movement, whereas high-intensity clenching contributes to joint fixation. Study Design: Randomized crossover trial. Level of Evidence: Level 3. Methods: Two experiments were conducted using 2 groups of 20 healthy adults. The 4 clenching conditions in experiment 1 were 0%, 12.5%, 25%, and 50% of the maximum voluntary contraction (MVC) of the masseter muscle. Experiment 2 consisted of 3 conditions: no-bite condition, moderate effort, and maximum effort (max condition). In experiment 1, spinal function and ankle dorsiflexion tasks were measured for each clenching condition, and the ankle dorsiflexion task was measured in experiment 2. Regarding spinal function, we measured spinal reciprocal inhibition (RI) and excitability of spinal anterior horn cells. For the ankle dorsiflexion task, ankle dorsiflexion MVC was performed for 3 seconds under each clenching condition. The items analyzed were reaction time, peak ankle dorsiflexion torque, and soleus (Sol)/tibialis anterior (TA) electromyography (EMG) ratio. Results: The results of experiment 1 illustrated that RI was significantly attenuated or eliminated with increasing clenching strength (>25% MVC). Spinal anterior horn cell excitability increased significantly with increasing clenching strength. The peak torque was significantly higher at 50% MVC than that at 0% MVC. In experiment 2, the peak torque was significantly higher under moderate and max conditions than no-bite condition, and the Sol/TA EMG ratio was significantly higher under max condition than that under moderate condition. Conclusion/Clinical Relevance: The results illustrated that during high-strength clenching (≥50% MVC), antagonist muscles are activated simultaneously to increase muscle strength. High-strength clenching improved kinetic performance (joint fixation), whereas low-strength clenching (<50% MVC) enhanced exercise performance (joint movement).