acinetobacter infection
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2021 ◽  
Vol 66 ◽  
pp. 109-116
Author(s):  
Ayman Kharaba ◽  
Haifa Algethamy ◽  
Mohamed Hussein ◽  
Fahad M. Al-Hameed ◽  
Adnan Alghamdi ◽  
...  


Author(s):  
ANGELINE ANJALI A. ◽  
ABIRAMASUNDARI V. K.

Objective: The present study is to determine the prevalence and antibiotic susceptibility of Acinetobacter species in samples collected from patients in tertiary care hospital in Chennai. Methods: A total of17,827patient’s clinical samples were collected from various wards and ICUs of Saveetha Medical College and Hospital, Chennai, Tamilnadu over a period of 7 mo [between January 2020 and July 2020]. All samples were tested in the microbiology lab of Saveetha Medical College and Hospital using standard operating procedures. Results: Out of 17,827 samples, 2,816 were culture positive. 122 of the isolates tested positive for Acinetobacter spp.and 81.1% of the isolates belonged to Acinetobacterbaumannii. Most of the infection occurred in the age group of 21-40 y and predominantly in female patients (female, male ratio 1.9:1).General wards contributed to 54.9% of the Acinetobacter infection, followed by ICU(27%) and OPD(18%). Maximum isolates were recovered from urine(34.4%) and endotracheal secretions(29.5%).60.7% of the Acinetobacterspp were multidrug-resistant(MDR)i.e. resistant to more than 3 antibiotic group.In our study, most Acinetobactersppwere resistant to penicillin(46-100%), third and fourth generation cephalosporin (36-61.5%), carbapenems (34.4-82.8%)and quinolones(39.3-46.7%). None of the isolates were resistant to colistin. 93.4% ofisolates were sensitive to tigecycline and 87.7% sensitive to amikacin. Conclusion: Our study observed a high incidence of MDR inAcinetobacterspp, which is in line with most of the research findings in recent times. Most of Acinetobacterspp were resistant to penicillin, third and fourth generation cephalosporins, quinolones, carbapenems,which is alarming as it leaves fewer options for the line of treatment. Some strains were sensitive to cefepime, ceftazidime, piperacillin-tazobactam, levofloxacin, imipenem and meropenem. Considering the increasing MDR nature of Acinetobacterspp a combination of the former along with colistin, tigecycline, amikacin(which have shown more than 85% sensitivity) would need to be studied.Also, strict measures to control the spread of Acinetobacter infection, better management of antibiotics usage and newer therapeutic option for treatment need to be looked at.



2020 ◽  
Vol 26 (5) ◽  
pp. 475-482 ◽  
Author(s):  
Yoshihiko Kiyasu ◽  
Shigemi Hitomi ◽  
Yasunori Funayama ◽  
Kazuhito Saito ◽  
Hiroichi Ishikawa


2019 ◽  
Vol 11 (01) ◽  
pp. 023-028 ◽  
Author(s):  
Asifa Nazir

Abstract BACKGROUND: Acinetobacter species are typical nosocomial pathogens causing infections and high mortality, almost exclusively in compromised hospitalized patients. Acinetobacter sp. are intrinsically less susceptible to antibiotics and have propensity to acquire resistance. Multidrug-resistant (MDR) Acinetobacter sp. blood infection in the neonatal intensive care unit patients create a great problem in hospital settings. AIMS: A prospective data analysis was performed over a one year period of all neonates admitted with sepsis who developed Acinetobacter infection and their antibiotic susceptibility pattern was carried out. MATERIALS AND METHODS: Blood samples of infected neonates were collected aseptically and cases of Acinetobacter septicemia were identified. Speciation of Acinetobacter species was done. Various risk factors were identified and their drug-sensitivity test was performed. RESULTS: The incidence of neonatal septicemia due to Acinetobacter species was 13.7% (49/357). Predominant species isolated was Acinetobacter baumannii (98%). The major symptoms were lethargy and poor feeding. The major signs were tachypnea, intercostal retraction, and respiratory distress. The major fetal risk factors were low birth weight and prematurity. High degree of resistance was observed to the various antibiotics used. Majority of the isolates (95.9%) were MDR while 93.68% were resistant to carbapenems as well as extensively drug resistant. However, all the strains were sensitive to colistin. CONCLUSION: MDR Acinetobacter septicemia in neonatal patients is becoming alarmingly frequent and is associated with significant mortality and morbidity. Therefore, rational antibiotic use is mandatory along with an effective infection control policy in neonatal intensive care areas of each hospital to control Acinetobacter infection and improve outcome.



2018 ◽  
Author(s):  
Daniel Bell ◽  
Yuranga Weerakkody


2018 ◽  
Vol 16 (1) ◽  
pp. 58-69
Author(s):  
I.Yu. Chicherin ◽  
◽  
I.P. Pogorelsky ◽  
I.A. Lundovskikh ◽  
К.Е. Gavrilov ◽  
...  


2017 ◽  
Vol 20 (9) ◽  
pp. A796
Author(s):  
KE Varghese ◽  
V Sudhapalli ◽  
D Kanad ◽  
R Vilakkathala


Vaccine ◽  
2017 ◽  
Vol 35 (26) ◽  
pp. 3387-3394 ◽  
Author(s):  
Sarah Ainsworth ◽  
Patrick M. Ketter ◽  
Jieh-Juen Yu ◽  
Rose C. Grimm ◽  
Holly C. May ◽  
...  


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