procam study
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2003 ◽  
Vol 31 (5) ◽  
pp. 1080-1084 ◽  
Author(s):  
P. Cullen

The link between raised levels of LDL (low-density lipoprotein) cholesterol in the blood and atherosclerosis is incontrovertible. The situation with regard to TRLs (triacylglycerol-rich lipoproteins) is not as clear. Nevertheless, there is substantial evidence that TRLs may in some cases be just as atherogenic as triacylglycerol-poor LDL. This review focuses on three aspects of the link between TRLs and atherosclerosis: (i) the epidemiological evidence for an association between raised levels of TRLs and atherosclerosis, with particular reference to the results of the PROCAM study; (ii) the possible pathophysiological contribution of TRL to atherogenesis at the level of the arterial wall; and (iii) the case for specific lowering of triacylglycerol levels to prevent atherosclerosis.


1994 ◽  
Vol 14 (1) ◽  
pp. 54-59 ◽  
Author(s):  
J Heinrich ◽  
L Balleisen ◽  
H Schulte ◽  
G Assmann ◽  
J van de Loo

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