REVIEWING THE THERAPEUTIC ACTIVITY OF VITAMIN D WITH ASTAXANTHIN

This article is an examination of the Rar The scientific development and subsequent “vitamin D and astaxanthin” continues to influence the researchers all over the globe today. This article examines the research done and published by researchers and scientists. Consideration of current trends and data in scientific queries and demonstrates further aspects of Therapeutic activity of vitamin D with astaxanthin. Additionally, this article explores options for vitamin D with asthaxanthin in orthopaedic. The combination of both result in enhanced endurance and walking distance in senior adults, as well as increased muscular strength and size (sarcopenia). Thus, in elderly adults, mobility, endurance, and strength were all increased using a single training strategy. Vitamin D with astaxanthin in ENT. The vitamin D and astaxanthin has been proven to possess effective activity against reactive oxygen species, cell apoptosis, inflammatory and auto immune disorders. Vitamin D with astaxanthin in gynecology.Antioxidants and vitamin D have been found to play an important role in reducing the causes of diseases linked with female infertility. Keywords: Infertility, antioxidant, otolaryngological diseases, musculoskeletal system, cartilage homeostasis

Understanding the Concept of Tubal Blockage in Ayurveda

Infertility is the failure to naturally conceive a child even after one or more years of regular unprotected coitus or to carry a pregnancy to full term. The situation gets gloomier as it is a problem often involving multiple factors, the diagnosis and treatment of which puts the family to physical and mental stress in addition to the financial expenses it involves. Tubal blockage is one of the important factors for infertility and it needs to be reviewed from the ancient texts. In this present article attempt has been made to review the tubal blockage in Ayurvedic texts. Keywords: Infertility, Vandhyatva, Ayurveda, Tubal blockage.

Uterine Anomalies in Infertility - An Evaluation by Diagnostic Hysterolaparoscopy

BACKGROUND About 10 - 15 % of reproductive age couples are affected by infertility.1 According to WHO 60 - 80 million couples currently suffer from infertility.2 Prevalence of infertility is rapidly increasing globally.3 Uterine factors of infertility include uterine anomalies, fibroid uterus, synechiae, Asherman’s syndrome, and failure of implantation without any known primary causes. Congenital uterine malformations are seen in 10 % cases of infertile women. We wanted to evaluate the anomalies of uterus in case of primary and secondary infertility by DHL (diagnostic hysterolaperoscopy). METHODS This is a hospital-based, observational study, conducted in the Department of Obstetrics and Gynaecology, VIMSAR, Burla, from November 2017 to October 2019. Diagnostic hysterolaparoscopy was done in 100 infertility cases. RESULTS In our study, uterine anomaly i.e. septate uterus was the most common hysteroscopic abnormaly found in 23 cases followed by submucous fibroid, polyp, synechiae and bicornuate uterus. CONCLUSIONS With proper selection of cases, and when done by skilled surgeon, can be considered as standard day care procedure for female infertility evaluation. KEYWORDS Infertility, Uterine Anomalies, Diagnostic Hysterolaparoscopy

Biopsychosocial Facets of Women Undergoing Infertility Treatment in Pondicherry: A Preliminary Study

Background: Physical and mental health are interrelated and influenced by various factors. Infertility is a physical condition that impacts the mental health of individuals experiencing it. It is a well-established fact that all over the world millions of couples are affected by infertility. In India many couples are infertile. Discovering that one is infertile is more than just another stressful event in one’s life. Being confronted by failure and helplessness, one feels increasingly anxious and immobilized. Aim: To understand the psychosocial problems faced by women due to infertility. Methodology: A Descriptive research design was adopted for the study. Women attending the clinic for treatment of infertility were the respondents. A semi-structured interview schedule was used to obtain the data. Results: Majority of the educated women married at a young age and sought treatment within five years of the marriage. They had menstrual problems and were referred by their families for treatment. Most of them had identified the problems and were into treatment. They were anxious, yet hopeful of success. They experienced problems of stigmatization in their own families and society and desired acceptance. Conclusion: This study highlighted the situation of couples facing infertility and the need for awareness of the condition of infertility. Support for couples by the multidisciplinary team inclusive of the Social Worker through the process of diagnosis and treatment, to maintain their health and mental health as they overcome the challenge of infertility is the need of the hour. Keywords: Infertility, psychosocial problems, stigma

MARGINAL DEHYDRATION OF FOLLICULAR FLUID IN PATIENTS WITH IVF AND ET AND ENDOCRINE DISORDERS

The aim of the paper is to identify the characteristics of follicular fluid (VF) structural composition using marginal dehydration method in patients with endocrine disorders and assisted reproductive technology (ART) for infertility treatment. Materials and Methods. By means of marginal dehydration method the authors examined VF structural composition in 247 patients with tubal-endocrine infertility genesis. All the women were enrolled in IVF and PE programs. Among them, patients with endocrine disorders were identified (149 women). Results. When studying the VF morphology by marginal dehydration method, the authors identified specifics of local VF organization in various forms of endocrine infertility. According to the local organization structure, the intensity of proliferative and destructive processes in the follicle was determined, and local ovarian homeostasis was assessed. These compositional peculiarities allowed us to suggest the possibility of using typical markers to predict outcomes of ART technologies and to personalize therapeutic approaches. Keywords: infertility, IVF, endocrine disorders, follicular fluid, marginal dehydration, morphotypes. Цель. Выявить особенности структуропостроения фолликулярной жидкости (ФЖ) методом краевой дегидратации у пациенток с эндокринными нарушениями, у которых для лечения бесплодия использованы методы вспомогательных репродуктивных технологий (ВРТ). Материалы и методы. Методом краевой дегидратации исследовано структуропостроение ФЖ у 247 пациенток с трубно-эндокринным генезом бесплодия, вошедших в программу ЭКО и ПЭ. Среди них были выделены пациентки с эндокринными нарушениям (149 женщин). Результаты. При исследовании морфологии ФЖ методом краевой дегидратации выявлены характерные особенности локальной организации ФЖ при различных формах эндокринного бесплодия. По структуре локальной организации определена степень выраженности пролиферативных и деструктивных процессов в фолликуле, дана оценка местного гомеостаза яичников. Эти особенности структуропостроения позволяют высказать предположение о возможности использования характерных маркеров для прогнозирования исходов технологий ВРТ и индивидуализировать терапевтические подходы. Ключевые слова: бесплодие, ЭКО, эндокринные нарушения, фолликулярная жидкость, краевая дегидратация, морфотипы.

EFECTOS DEL MALATHION SOBRE LA ESPERMATOGÉNESIS DE RATONES MACHOS JÓVENES DE LA CEPA BALB-C53.

EFECTOS DEL MALATHION SOBRE LA ESPERMATOGÉNESIS DE RATONES MACHOS JÓVENES DE LA CEPA BALB-C53. Walter Félix De la Cruz Ramírez, Karina Mabel Luján Mavila, Ubaldo Efraín Miranda Soberón DOI: https://doi.org/10.33017/RevECIPeru2004.0006/ RESUMEN El presente trabajo tiene como objetivo demostrar los efectos tóxicos de una sola dosis del pesticida órganofosforado Malathion sobre la espermatogénesis de ratones jóvenes. Para ello 50 ratones machos jóvenes de 30 días de edad de la cepa Balb-C53 fueron repartidos aleatoriamente en dos grupos: uno experimental (E), que recibió 1/3 de la DL50 del Malathion comercial (Extrathion) diluido en aceite de maíz por vía intraperitoneal, y otro Control (C) que recibió sólo aceite de maíz por la misma vía. Los ratones tratados y sus controles fueron sacrificados en grupos de 5 a los: 4, 8, 18, 28 y 40 días después de una sola aplicación del Malathion, y luego se midió el conteo y la morfología espermática. Después de la inyección del Malathion se observó disminución del conteo espermático a los 28 y 40 días postexposición (E: 458,00 y 519,80millones esp./ml vs C: 683,60 y 796,40millones esp./ml respectivamente, para un p£0,05) y aumento de la teratozoospermía a los 4 y 8 días postexposición (E: 13,60 y 8,40 % de esp. anormales vs C: 4,60 y 2,40 % de esp. anormales respectivamente, para un p£0,05). En conclusión, la administración de una sola dosis de Malathion por vía intraperitoneal, puede afectar la espermatogénesis de los ratones machos jóvenes. Palabras Clave: Infertilidad, Espermatogénesis, Órganofosforado, Malathion. ABSTRACT The Present work aims at establishing the toxic effects on spermatogenesis of a single injection of the pesticide Malathion in young mice. For it, 50 young male Balb-C53 mice of 30 days of age was distributed aleatorily in two groups: Experimental (E) that received 1/3 de la LD50 of the commercial Malathion (Extrathion) diluted in corn oil injected intraperitoneally, and another Control (C) that only received corn oil for the same road. Treated mice and their controls were sacrificed in groups of 5 at: 4, 8, 18, 28 and 40 days after injection of the Malathion, for then to measure the count and morphology spermatic. After the injection of the Malathion was observed decrease of the spermatic count at 28 and 40 days postinjection (E: 458,00 and 519,80millons esp./ml vs C: 683,60 y 796,40millons esp./ml respectively, p£0,05) and increase of the teratozoospermia at 4 and 8 days postinjection (E: 13,60 y 8,40 % de esp. abnormal vs C: 4,60 y 2,40 % de esp. abnormal respectively, p£0,05). In conclusion the administration of a single dose of Malathion intraperitoneally it can affect the spermatogenesis of the young male mice. Keywords: Infertility, Spermatogenesis, Organophosphorous, Malathion.