The problem of animal schistosomiasis is multifaceted. It intertwines veterinary, health, social and economic issues. The current state of the epizootology of schistosomiasis in the ecological conditions of the Aral Sea region is presented. Spontaneous infection of farm animals with mature Schistosoma turkestanica was 55.2% in cattle, sheep – 33.0%, horses – 21.5%, goats – 15.5% and camels – 10.2%. At individual farms of the Bozatau, Kungradsky, Muinaksky, Amudarya and other districts, cattle infection reached up to 100% with a high degree of infection intensity. We noted the cyclical nature of the epizootic of schistosomiasis in cattle in the Aral Sea region. The alternation of cyclicity is observed at specified intervals – from 15 to 20 years. The ups and downs in the infection intensity alternate with a certain accuracy, according to which epizootics of schistosomiasis can be predicted for several years in advance. Currently, science has developed the necessary prerequisites for a sharp decrease in the incidence of animals with schistosomiasis and the elimination of invasion in individual foci. This is achieved by a complex of therapeutic and preventive measures, as well as the use of progressive methods and technology of animal husbandry