Compound Figures: A Multi-Channel View of Communication and Psychological Plausibility

Philosophical views of language have traditionally been focused on notions of truth. This is a reconstructive view in that we try to extract from an utterance in context what the sentence and speaker meaning are. This focus on meaning extraction from word sequences alone, however, is challenged by utterances which combine different types of figures. This paper argues that what appears to be a special case of ironic utterances—ironic metaphorical compounds—sheds light on the requirements for psychological plausibility of a theory of communication and thus presents a different view of communication and language to that dominant in philosophy of language. In the view presented here, the hearer does not extract the speaker’s communicative intention from the sequence of words in the utterance, but from other channels (gesture, intonation, facial expression), so as to constrain the inferential space for the sentence and speaker meaning. Specifically, we examine an example of ironic metaphor discussed by Stern (2000). He argues that ironic content is logically dependent on metaphorical content, but makes no claims about how psychologically plausible this is in terms of the processing order. We argue that a straightforward translation of logical order into temporal order makes little sense. The primary sticking point is that without a prior understanding of the speaker’s communicative intentions, it is computationally more challenging to process the sub-component meanings. An alternative solution based on communicative channels leads us to a more psychologically plausible account of the structure of communicative acts and intentions. This provides support for the psychological realism of a richer theory of communicative intent.

Evaluation of Strength and Muscle Activation Indicators in Sticking Point Region of National-Level Paralympic Powerlifting Athletes

Background: The sticking region is considered an intervening factor in the performance of the bench press with high loads. Objective: To evaluate the strength indicators in the sticking point region in Powerlifting Paralympic athletes. Methods: Twelve Brazilian Powerlifting Paralympic athletes performed maximum isometric force (MIF), rate of force development (RFD), time at MIF, velocity, dynamic time in sticking, and surface electromyography in several distances from the bar to the chest. Results: For velocity, there was a difference between the pre-sticking and sticking region (1.98 ± 0.32 and 1.30 ± 0.43, p = 0.039) and dynamic time between the pre-sticking and the sticking region (0.40 ± 0.16 and 0.97 ± 0.37, p = 00.021). In static test for the MIF, differences were found between 5.0 cm and 15.0 cm (CI 95% 784; 1088; p = 0.010) and between 10.0 cm and 5.0 cm (CI 95% 527; 768; p < 0.001). Regarding the RFD, differences were found (CI 95% 938; 1240; p = 0.004) between 5.0 cm and 25.0 cm and between 10.0 cm and 25.0 cm (CI 95% 513; 732; p < 0.001). In relation to time, there were differences between 5.0 cm and 15.0 cm (CI 95% 0.330; 0.515; p < 0.001), 5.0 cm, and 25.0 cm (CI 95% 0.928; 1.345; p = 0.001), 10.0 cm and 15.0 cm (p < 0.05) and 15.0 cm and 25.0 cm (p < 0.05). No significant differences were observed between the muscles in electromyography, although the triceps showed the highest muscle activation values. Conclusions: The maximum isometric force, rate of force development, time, velocity, and dynamic time had lower values, especially in the initial and intermediate phases in the sticking region.

Extensive Evaluation of Force Fields for G-Quadruplexes

<p><a></a><a></a><a>G-Quadruplexes</a> (GQs), folded by guanine-rich <a></a><a></a><a>nucleic acid</a> <a></a><a></a><a></a><a>sequences</a>, involve in gene expression processes and closely associated with the formation of tumors. So far, GQ has drawn widespread attention for its notable application of serving as potential anti-cancer target. Recently, theoretical studies for GQs have achieved significant progress, most of which are inseparable from molecular dynamics (MD) simulation. As a necessary tool to explore <a></a><a></a><a>dynamics behavior</a> of molecules, MD simulations strictly depend on force field parameters, which is a sticking point to obtain accurate results. Currently, many force fields for nucleic acids have been developed, but none of them have been accepted widely for GQs. In this paper, we selected five popular force fields, which are parmbsc0, parmbsc1, OL15, Drude2017 and AMOEBANUC17, and conducted explicit-solvent MD simulations on two DNA GQs respectively. We evaluated these force fields from many aspects in detail. Meanwhile, we compared conformational energy using quantum chemistry calculations. With the comprehensive evaluation, Drude2017 achieved better description for GQs, which we suggest that using Drude2017 force field should <a></a><a></a><a>be taken into account</a> first when investigating GQs by MD simulation<a></a><a></a><a></a><a></a><a>.</a></p>

Extensive Evaluation of Force Fields for G-Quadruplexes

<p><a></a><a></a><a>G-Quadruplexes</a> (GQs), folded by guanine-rich <a></a><a></a><a>nucleic acid</a> <a></a><a></a><a></a><a>sequences</a>, involve in gene expression processes and closely associated with the formation of tumors. So far, GQ has drawn widespread attention for its notable application of serving as potential anti-cancer target. Recently, theoretical studies for GQs have achieved significant progress, most of which are inseparable from molecular dynamics (MD) simulation. As a necessary tool to explore <a></a><a></a><a>dynamics behavior</a> of molecules, MD simulations strictly depend on force field parameters, which is a sticking point to obtain accurate results. Currently, many force fields for nucleic acids have been developed, but none of them have been accepted widely for GQs. In this paper, we selected five popular force fields, which are parmbsc0, parmbsc1, OL15, Drude2017 and AMOEBANUC17, and conducted explicit-solvent MD simulations on two DNA GQs respectively. We evaluated these force fields from many aspects in detail. Meanwhile, we compared conformational energy using quantum chemistry calculations. With the comprehensive evaluation, Drude2017 achieved better description for GQs, which we suggest that using Drude2017 force field should <a></a><a></a><a>be taken into account</a> first when investigating GQs by MD simulation<a></a><a></a><a></a><a></a><a>.</a></p>

Chorioretinal Alterations Induced by Preeclampsia

Hypertension during pregnancy, which is essentially a microvascular disease that destroys the end-organ microcirculation, should not be underestimated, as it could lead to organ failure in the kidneys, lungs, and brain. Preassessment of the microcirculatory state through systematic observation of the fundus has been proven to be noninvasive and feasible. Although hypertension in preeclampsia patients will resolve after childbirth, the sticking point is determining the best termination moment. Early diagnosis and treatment can prevent long-term ocular complications and cardiovascular risks for pregnant women in the future. In order to adjust the treatment strategy through more sensitive and precise fundus changes, we comprehensively summarized the common structural changes in the fundus in preeclampsia patients, including changes in the blood vessels, choroid, and retina, as well as the application of quantitative observation for chorioretinal alterations in recent years.

Exploring the Significance of Some Cultural and Religious Factors in Domestic Violence among Muslim Immigrant Australians

This is a largely qualitative research study that explores the issue of domestic violence (DV), particularly against Australian Muslim immigrant women. It uses a sectionality approach to focus on the closely linked factors of culture and religion that may engender DV. As patriarchy is a cultural risk factor for DV, a semiquantitative approach was taken by identifying the regions where the immigrants originated. Furthermore, it was found that Islamicallydiscordant patriarchal interpretations of the Quran and Sunnah employed by influential late classical scholars based in eastern Muslim lands has affected tafsir and legal rulings, especially of non-Maliki madhhabs. The ‘sticking point’ of physically striking women in verse 4:34 is potentially resolved as a provision for safeguarding wives in conflict zones. This research also supports the call for reforms by scholars in Qur’anic exegetical readings and fiqhi rulings on family law. Finally, this study recommends several policy recommendations enlightened with the understanding that Islam supports a compassionate and egalitarian view of marriage.