COMPARATIVE EFFECT OF PROGRESSIVE SPEED TRAINING PROGRAM OF TRIBAL AND NON-TRIBAL BOYS

Speed is one of the vital motor abilities that need to start the developmental process at the early ages of the players. The study aims to identify the progression of progressive speed training basis on the duration of training of the Santali tribe and Bengali teen boys. Subjects were Santali tribe and Bengali adolescent schoolboys and their ages ranged between 13 to 15 years selected from Bankura District of West Bengal, India. These two groups were further divided into control and experimental groups and in each of the groups, there were 20 students. Initially, 4 weeks of uniform conditioning trainings were given to all groups before the pretest T1 was conducted. Further, consecutively 3 more post-tests were conducted every 4 weeks after providing progressive speed training. For the comparison, MANOVA, ANOVA, and LSD post hock test were employed and the Mean value was seen in the descriptive part. The result of the study reveals that Non-tribal (Bengali) and Tribal (Santali) adolescent schoolboys responded positively with the designed progressive speed training. This progression of tests timing took place progressively over time on the Bengali and Santali boys almost similarly. Though the Santali boys took the upper hand over Bengali boys numerically at the final stage of progression in the timing of the speed test, on the contrary in the first two post-tests, T2 & T3 progression took place almost in the same fashion. It is concluded that alike progressive speed training is almost equally effective for Santali tribe and Bengali adolescent boys for the development of sprinting ability. <p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0856/a.php" alt="Hit counter" /></p>

Intermediate-Dose Cyclophosphamide Versus Plerixafor and Granulocyte Colony Stimulating Factor (G-CSF) for Peripheral Blood Progenitor Cell (PBPC) Mobilization in Patients with Multiple Myeloma (MM) Treated with Novel Induction Chemotherapies – A Multicenter Analysis

Abstract 4409 Introduction: PBPC mobilization with intermediate-dose cyclophosphamide (3–4 gm/m2) (ID-CY) and G-CSF when compared to low-dose CY (1–2 gm/m2)-based strategies, has been shown to have a favorable risk/benefit profile in MM patients (pts) receiving novel induction therapies (Hamadani M. BBMT 2012). However the relative efficacy of ID-CY as compared to plerixafor in PBPC mobilization in MM pts is not known. Herein we report outcomes of ID-CY/G-CSF mobilization compared to plerixafor/G-CSF mobilization in MM pts treated with novel induction regimens. Methods: This multicenter outcomes study includes 84 pts who underwent a planned, single autograft within 1-year of starting induction therapy with novel chemotherapy agents (thalidomide, lenalidomide, bortezomib) from 2003–2012. Consecutive pts undergoing mobilization with ID-CY/G-CSF (3–4 gm/m2) (n=55) at one institution were compared against consecutive pts receiving plerixafor/G-CSF (0.24 mg/kg) (n=29) at a different transplant center. At baseline the two groups were compared for parameters predicting mobilization failure. In order to assess efficiency of PBPC mobilization, we evaluated peak peripheral blood (PB) CD34+ cell counts, CD34+ cell yield on day1 of collection, total CD34+ cell collection, and total number of apheresis sessions. Mobilization failure was defined as failure to collect ≥2 ×106 cells/kg body weight. All pts with normal renal function received uniform conditioning with Mel200 (MEL140 if serum creatinine was ≥2 mg/dl). Results: At baseline, the ID-CY and plerixafor cohorts were well balanced (Table 1). No difference was observed in the use of lenalidomide (p=0.3). Compared to plerixafor, ID-CY use was associated with higher median peak PB CD34+ cell count (63/μl vs. 160/μl, p=0.01), CD34+ yield on day 1 of collection (6.5 ×106/kg vs. 11.7 ×106/kg, p=0.004), and total CD34+ cell yield (10.5 ×106/kg vs. 24.9 ×106/kg, p=0.001). Median numbers of apheresis sessions were 2.2 in each group (p=0.9). No mobilization failures were seen in either group. There was no difference in the proportion of pts collecting ≥5×106/kg CD34+ cells in either group (93% vs. 96%, p=0.6), but more pts in ID-CY cohort collected ≥10×106/kg CD34+ cells (55% vs. 78%, p=0.02). Neutrophil engraftment was significantly faster (9.9 days vs. 13.1 days, p<0.001) in the ID-CY pts, likely because of higher infused CD34+ cell dose. Rate of adverse events were higher in the ID-CY cohort including neutropenic fevers (p=0.02), intravenous antibiotic use (p=0.03), hospitalization (p=0.05) and packed red cell transfusions (p=0.007). Conclusion: In the era of novel agents compared to plerixafor, ID-CY produced a more robust PBPC mobilization, faster engraftment, but was associated with significantly higher (but manageable) toxicity, and no difference in mobilization failure rates. These data support use of either ID-CY or plerixafor-based PBPC mobilization in MM pts undergoing stem cell collection following novel induction therapies. Disclosures: Awan: Allos Therapeutics: Speakers Bureau. Hamadani:Conquer Cancer Foundation of ASCO: Research Funding; ASBMT & Millennium New Investigator Award: Research Funding; American Cancer Society 116837-IRG-09–061-01: Research Funding; Celgene Corp: Speakers Bureau.

HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced-intensity conditioning

The impact of human leukocyte antigen (HLA) mismatch after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIT) using unrelated donors (UD) is unclear, and may be modulated by T-cell depletion. We therefore examined outcomes of 157 consecutive patients undergoing RIT after uniform conditioning with fludarabine, melphalan, and alemtuzumab (FMC). Donors were 10/10 HLA-matched (MUDs, n = 107) and 6 to 9/10 HLA-matched (MMUDs, n = 50), with no significant differences in baseline characteristics other than increased cytomegalovirus seropositivity in MMUDs. Rates of durable engraftment were high. Graft failure rates (persistent cytopenias with donor chimerism) were similar (8% vs 3%, P = .21), though rejection (recipient chimerism) was more frequent in MMUDs (8% vs 0%, P < .01). There were no significant differences between donors in the incidences of acute graft-versus-host disease (GVHD; 20% vs 22% grade 2-4, respectively, P = .83), chronic extensive GVHD (3-year cumulative incidence [CI] 23% vs 24%, P = .56), or treatment-related mortality (1-year CI 27% vs 27%, P = .96). Furthermore, there was no difference in 3-year overall survival (OS; 53% vs 49%, P = .44). Mismatch occurred at the antigenic level in 40 cases. The outcome in these cases did not differ significantly from the rest of the cohort. We conclude that RIT using HLA-mismatched grafts is a viable option using FMC conditioning.