Safety reporting study of nonsteroidal anti-inflammatory drugs in a tertiary care teaching hospital, SIMS, Uttar Pradesh

Background: The nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used drugs to treat pain and inflammation. Although NSAIDs are having enormous clinical use, but are not devoid of adverse drug reactions (ADRs) as peptic ulcer, gastritis, renal, neurological reactions etc. So, this pilot study is intended to assess the incidence and pattern of ADRs of the NSAIDs in a tertiary care teaching hospital.Methods: Total 600 Orthopaedic out-patients of SIMS, Hapur were enrolled in the study to observe the risk of ADRs due to NSAIDs. All the ADRs were further analysed in relation to age, sex, types of drug and its pattern etc. The causality was analysed by using Naranjo’s Algorithm and severity was analysed by using the Hartwing and Siegel scale.Results: Out of the 600 patients with NSAID therapy, 35 patients (5.83%) experienced total 10 types of ADRs. The adverse drug reactions observed by the patients were gastric symptoms, headache, urticaria, oedema etc. The most frequently observed ADR was gastritis. With all the prescribed drugs Tab Diclofenac sodium accounted for 57.14% and Paracetamol for 11.42% of all the ADRs. According to Naranjo’s Algorithm 62.87% ADRs were possible’ and 37.14% were of probable type and ADRs were mostly mild in severity.Conclusion: In this study, incidence of adverse reactions to nonsteroidal anti-inflammatory drugs was 5.83 and the most common implicated drug for the ADRs were Diclofenac sodium. Most of the adverse effects were mild and tolerable.

CASE STUDY ON IFOSMADIDE-INDUCED CYSTITIS

Adverse drug response elaborates, is response to the drug which is caused to an organ or tissue damage for normal dose in the patients for the prophylaxis, 22 years male patient was hospitalized with complaints of relapsed Hodgkin’s lymphoma (HL) using post-Adriamycin, Bleomycin, Binblastine, and Dacarbazine regimen. The patient had treated HL with ICE regimen, after 24 hours of treatment with prescribed the ICE regimen, The patient was observed with following symptoms like vomiting, painful burning micturition and laboratory investigations reported. Abnormal then we suggested Mesna 3 days for prophylactic course then symptoms were not found and patient was discharged. We conducted Adverse drug reaction (ADR) assessment was resulted as probable type and we can probably prevent this type of ADR.

Evidence for the true type-locality of Rhamdia quelen (Siluriformes: Heptapteridae), and the geographical origin and invalid neotype designation of four of its synonyms

ABSTRACT Historical information on the probable type-locality of Pimelodus quelen and of its four junior synonyms that share the same neotype, Pimelodus namdia, Pimelodus sebae, Heterobranchus sextentaculatus, and Silurus rivularis, is presented and discussed. The neotype designation for those four species is deemed invalid for not complying with the provisions of the International Code of Zoological Nomenclature, making it technically possible to revalidate any of the four taxa from the synonymy of Rhamdia quelen without having to address the International Commission of Zoological Nomenclature. The type-locality of both Curimata gilbert and Callichthys asper are also restricted to rio Macacu at the village of Japuíba, State of Rio de Janeiro, Brazil.

Microstructure Formation of LiTiZn Ferrite Ceramics during Radiation-Thermal Sintering

The effect of intensification of the compaction rate of ferrite compacts under irradiation conditions with a high-power electron beam both in the heating regime and in the isothermal stage of sintering was established. The compaction mechanisms of the compacts are different at each of these stages. The intensification of compaction at the non-isothermal stage in radiation-thermal conditions is due to processes involving the liquid phase. The role of bismuth oxide in the compaction of the material at the isothermal stage of sintering is unessential, but its influence is significant in recrystallization processes. Under of Ivensen’s phenomenology, compaction curves are explained by the deceleration of annealing of structural defects responsible for the fluidity of the material. Dislocations are the most probable type of defects, satisfying the detected regularities.

Welding Incident Mitigation at Mechanical Engineering

Mechanical engineering is one of the most dynamically developing industries in many countries. Welding at the same time is one of the main processes of metal working in various industries, especially in mechanical engineering. The World Health Organization considers welding works to be harmful and dangerous for health. The present paper identifies the main factors leading to injuries during welding works at a stationary workplace. A causal tree for a welding incident has been devised and analyzed. Probability of an incident was estimated by using the expert evaluation method. It was found out that machine injury is the most probable type of incident. The aim of this article is to work out welding incident mitigation measures in the industrial sphere based on the incident probability assessment

The Southern 2MASS Active Galactic Nuclei Survey: Spectroscopic Follow-up with Six Degree Field

The Two Micron All-Sky Survey (2MASS) has provided a uniform photometric catalog to search for previously unknown red active galactic nuclei (AGN) and Quasi-Stellar Objects (QSOs).We have extended the search to the southern equatorial sky by obtaining spectra for 1182 AGN candidates using the six degree field (6dF) multifibre spectrograph on the UK Schmidt Telescope. These were scheduled as auxiliary targets for the 6dF Galaxy Redshift Survey. The candidates were selected using a single color cut of J – Ks > 2 to Ks ≲ 15.5 and a galactic latitude of lbl > 30°. 432 spectra were of sufficient quality to enable a reliable classification. 116 sources (∼27%) were securely classified as type I AGN, 20 as probable type I AGN, and 57 as probable type II AGN. Most of them span the redshift range 0.05 < z < 0.5 and only 8 (∼6%) were previously identified as AGN or QSOs. Our selection leads to a significantly higher AGN identification rate amongst local galaxies (>20%) than in any previous (mostly blue-selected) galaxy survey. A small fraction of the type I AGN could have their optical colors reddened by optically thin dust with AV < 2 mag relative to optically selected QSOs. A handful show evidence of excess far-infrared (IR) emission. The equivalent width (EW) and color distributions of the type I and II AGN are consistent with AGN unified models. In particular, the EW of the [Oiii] emission line weakly correlates with optical–near-IR color in each class of AGN, suggesting anisotropic obscuration of the AGN continuum. Overall, the optical properties of the 2MASS red AGN are not dramatically different from those of optically-selected QSOs. Our near-IR selection appears to detect the most near-IR luminous QSOs in the local universe to z≃0.6 and provides incentive to extend the search to deeper near-IR surveys.

The Types of Phasmida in the Zoological Institute, Russian Academy of Sciences, St. Petersburg (ZMAS)

Type specimens of 67 taxa of Phasmida (including probable type specimens of 24 taxa) have been located in the Zoological Institute, Russian Academy of Sciences, St. Petersburg. The species are listed alphabetically, with the number of specimens, sex and locality data.

The Types of Phasmida in the Zoological Institute, Russian Academy of Sciences, St. Petersburg (ZMAS)

Type specimens of 67 taxa of Phasmida (including probable type specimens of 24 taxa) have been located in the Zoological Institute, Russian Academy of Sciences, St. Petersburg. The species are listed alphabetically, with the number of specimens, sex and locality data.