Display glass substrate as a brittle material is very challenging to machine due to its excellent physical, mechanical, electrical, and optical properties such as high hardness, high strength, high wear resistance, good fracture toughness, good chemical stability, and good thermal stability. On the basis of Griffith fracture mechanics, our theoretical analysis indicated that edge grinding of the display glass substrate is under brittle mode when grinding with the given conditions, which was verified by the experimental studies of ground glass edge surface topography and fractured surface obtained. Grinding force (Fy) in the vertical direction was much larger than grinding force (Fx) in the horizontal direction, causing a large compressive stress acting on the grinding glass edge. Grinding torque was slightly increased with the increase of grinding speed. Grinding temperature was very high when measured under dry grinding compared with measurement under high-pressure coolant. Grinding of glass substrate edge was performed partially under ductile mode machining in the experimental conditions, which can be attributed to and contributed by those micro cutting edges generated by the fractured diamond grit on the grinding wheel surface.