A Novel ECG Eigenvalue Detection Algorithm Based on Wavelet Transform

This study investigated an electrocardiogram (ECG) eigenvalue automatic analysis and detection method; ECG eigenvalues were used to reverse the myocardial action potential in order to achieve automatic detection and diagnosis of heart disease. Firstly, the frequency component of the feature signal was extracted based on the wavelet transform, which could be used to locate the signal feature after the energy integral processing. Secondly, this study established a simultaneous equations model of action potentials of the myocardial membrane, using ECG eigenvalues for regression fitting, in order to accurately obtain the eigenvalue vector of myocardial membrane potential. The experimental results show that the accuracy of ECG eigenvalue recognition is more than 99.27%, and the accuracy rate of detection of heart disease such as myocardial ischemia and heart failure is more than 86.7%.

Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium byWithania somniferaLeaf Extract

We investigated the protective role ofWithania somniferaleaf extract (WSLEt) on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (85 mg/kg body weight (b.w.)) administered to rats for two consecutive days caused a significant increase in cardiac troponin I (cTnI) levels and serum lipid profiles, as well as the activities of some marker enzymes. In addition to these diagnostic markers, there were increased levels of lipid peroxidation (LPO) and decreased activities of enzymatic antioxidants (superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRx), and glutathione-S-transferase (GST)) in the myocardium. However, oral pretreatment (100 mg/kg b.w.) with WSLEt for 4 weeks elicited a significant cardioprotective activity by lowering the levels of cTnI, lipid profiles, and marker enzymes. The levels of LPO products were also significantly decreased. Elevated activities of antioxidant enzymes were also observed in rats pretreated with WSLEt. As further confirmed histopathologically, our findings strongly suggest that the cardioprotective effect of WSLEt on myocardium experiencing ISO-induced oxidative damage may be due to an augmentation of the endogenous antioxidant system and an inhibition of LPO in the myocardial membrane. We conclude that WSLEt confers some protection against oxidative damage in ISO-induced MI in rats.

Catecholamine toxicity triggers myocardial membrane destabilization in rats: thymol and its counter action

The present manuscript deals with the protective action of thymol against isoproterenol induced cardiotoxicity by reinstating ATPases and minerals as evidenced by decreased myocardial infarct size.