Today, the highest importance is given to the patient’s safety and ethics during the clinical trials. The regulatory authorities take each and every aspect into consideration to protect the safety, rights and consent of the subjects during the phases of clinical trials. Besides the applications like IND, NDA further strengthen these above parameters. However, all these safety measures are a result of our previous experiences in history such as Thalidomide tragedy, Sulphanilamide disaster, Nazi’s experiments, Tuskegee syphilis studies. All these disasters are due to unethical behavior, lack of knowledge on safety, no keen idea on pharmacovigilance, no proper data storage, inexperience etc., which led to many disasters resulting in the deaths of many innocent lives and some permanent damage to the persons consuming these drugs either by force or voluntarily. This article mainly focuses on the drug tragedies and drugs introvert from the market, due to the lack of knowledge on clinical trials.