Abstract
This chapter traces melancholia from the early nineteenth century, when its nosological status as an independent disease category was contested, up until the 1860s. At this time, the view that insanity could be chiefly of the emotional kind, that is, largely without delusion of thought, was rapidly gaining ground among European medical writers. This shift from more traditional views of madness was crucial as it provided the epistemological foundation and conceptual framework necessary for disordered mood to become a possible and plausible medical concept. The chapter charts the nosological trajectory of melancholia through the work mid-century British physicians, who began to appropriate physiological language to speak about disordered mood and melancholia, increasingly abandoning older models.