The chapter provides a brief overview of the history of simulation modeling and of philosophical accounts dealing with simulation. Computer and simulation modeling, it is stated, do form a new exploratory and iterative type of mathematical modeling. Four aspects are introduced: experiment and artificiality, visualization, plasticity, and epistemic opacity. The key thesis is that the novelty of simulation modeling rests on how these aspects are combined into a combinatorial style of reasoning. The computer as an instrument does not only speed up calculations but also channels mathematical modeling. This is exerting transformational power on central concepts like solution, validation, and the real—instrumental divide.