The chapter argues that over the course of the seventeenth and early eighteenth centuries, medical testimony was increasingly sought in coroners’ inquests and that by at least the late sixteenth and early seventeenth centuries medical knowledge and forensic medicine was already sophisticated enough to provide an accurate assessment of the majority of medical evidence that was regularly encountered. However, it is further argued that forensic medicine and medical testimony, even when perfectly competent and accurate, were in no way necessary for effective policing or criminal investigation. Instead, it is demonstrated that, then as now, a combination of local knowledge, communal policing and witness testimony was the key to effective policing and criminal investigation. Thus, even if forensic medicine was not sufficiently advanced by the sixteenth century to detect all violent deaths, the crucial tools for effective regulation of lethal violence—witnesses’ testimony and communal knowledge—were in place throughout the early modern period. As such, the question of whether or not the primitive nature early modern forensic medicine was a barrier to the effective regulation of inter-personal violence is immaterial. Instead, the chapter concludes that criminal investigation was efficient and effective enough to maintain the state’s monopoly of violence.