Design and Optimization of Novel Vaginal Microsphere Gel of Clotrimazole

The objective of the study was to develop and evaluate sustained release microsphere gel for the drug clotrimazole to be administered through the vaginal route. The effect of polymer ethylcellulose and carbopol 934 on entrapment efficiency and diffusion behavior were investigated respectively. A 32 full-factorial design was used to optimize the formulation of Microsphere gel. Microspheres were characterized by SEM, FTIR, Entrapment efficiency, and particle size. Gels were evaluated for in-vitro drug release in simulated vaginal fluid. The microsphere loaded with clotrimazole in bioadhesive carbopol gel formulation was evaluated for various physicochemical studies and was found to be satisfactory. The rheological profile shows the gel formation at desired condition. It is evaluated for spreadability, drug content, In-vitro drug diffusion, stability study, and bioadhesive study. It may be concluded that spray drying is a suitable method for microsphere preparation and microsphere gel can be used as a novel drug delivery system to prolonge release of clotrimazole for vaginal candidiasis.

A Comprehensive Review on Anti-Inflammatory Activity of The Traditional Plants Plumbago zeylanica(Chitra)

Medicinal plants have long been utilised as a source of medicine and are in high demand throughout the world. They've been around for a long time, and they've been utilised to cure and prevent ailments. Plumbago zeylanica is a medicinal plant that is frequently utilised for its medicinal properties. It contains several bioactive compounds like napthoquinones, flavonoids, alkaloids, glycosides, steroids, tri-terpenoids, tannins, fixed oils, fats, proteins, etc. among all plumbagin is most important bioactive compounds. It possesses wide range of pharmaceutical activities such as anti-inflammatory, antimicrobial, anti-cancer, anti-ulcer, antidiabetic etc. Several investigations on its pharmacological activity have been conducted. The goal of this review is to provide a comprehensive understanding of P. zeylanica's chemical composition and pharmacological action.