scholarly journals Lipid Based Drug Delivery System: An Approach to Enhance Bioavailability ofPoorly Water Soluble Drugs

2020 ◽  
Vol 19 (2) ◽  
pp. 693-714
Author(s):  
Sachin Aryal ◽  
Roshan Gyawali ◽  
Yuvraj Regmi ◽  
Beny Baby
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Water Soluble ◽  
Water Soluble Drugs

scholarly journals Formulation development of an albendazole self-emulsifying drug delivery system (SEDDS) with enhanced systemic exposure / Razvoj samoemulzifirajućeg sustava za isporuku albendazola (SEDDS) s pojačanom sistemskom apsorpcijom

2012 ◽  
Vol 62 (4) ◽  
pp. 563-580 ◽  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Systemic Exposure ◽  
Tween 80 ◽  
Water Soluble ◽  
Formulation Development ◽  
Suspension Formulation ◽  
Water Soluble Drugs

The aim of the study was to develop and evaluate a self- -emulsifying drug delivery system (SEDDS) formulation to improve solubility and dissolution and to enhance systemic exposure of a BCS class II anthelmetic drug, albendazole (ABZ). In the present study, solubility of ABZ was determined in various oils, surfactants and co-surfactants to identify the microemulsion components. Pseudoternary phase diagrams were plotted to identify the microemulsification existence area. SEDDS formulation of ABZ was prepared using oil (Labrafac Lipopfile WL1349) and a surfactant/ co-surfactant (Tween 80/PEG 400) mixture and was characterized by appropriate studies, viz., microemulsifying properties, droplet size measurement, in vitro dissolution, etc. Finally, PK of the ABZ SEDDS formulation was performed on rats in parallel with suspension formulation. It was concluded that the SEDDS formulation approach can be used to improve the dissolution and systemic exposure of poorly water-soluble drugs such as ABZ.

Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System of Naproxen

2015 ◽  
Vol 8 (1) ◽  
pp. 2715-2722
Author(s):  
Saritha D ◽  
Penjuri Subhash Chandra Bose ◽  
Nagaraju Ravoru
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Water Soluble ◽  
Size Analysis ◽  
Albino Rats ◽  
Significant Activity ◽  
Water Soluble Drugs

Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro or nanoemulsions containing the solubilized drug. The objective of the present work was to formulate a self nanoemulsifying drug delivery system (SNEDDS) for naproxen. Naproxen SNEDDS were formulated using Labrafac PG (Oil), Span 80 (Surfactant) and propylene glycol (Co surfactant). The developed SNEDDS were evaluated for turbidimetry, droplet size analysis, zeta potential, refractive index, viscosity, drug content and in vitro diffusion profiles. All formulations of naproxen SNEDDS showed globule size in nanometric range, good stability with no phase separation and rapidly formed clear emulsion. All formulations showed more than 95% of drug release at the end of 60 min. The SEDDS showed improved dissolution rate compared to pure naproxen. Anti-inflammatory studies were conducted in Wistar strain male albino rats and ibuprofen SNEDDS showed more significant activity than the pure drug. The study illustrated the potential of naproxen SNEDDS for oral administration and its biopharmaceutical performance.

scholarly journals Solid-State Lipid - Based Lipid Drug Delivery System

2021 ◽  
Vol 001 (01) ◽  
Author(s):  
Mamta Nasit ◽  
Meshva Patel ◽  
Ajay Solanki ◽  
Jayendrakumar Patel
Keyword(s):  
Drug Delivery ◽  
Solid State ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
Aqueous Solubility ◽  
Water Soluble ◽  
Different Types ◽  
Water Soluble Drugs ◽  
Lipid Excipients

In recent time, about 70% of new molecules discovered or under discovery are lipophilic in nature with low aqueous solubility which makes a great challenge for formulation scientists to making these molecules to be have a sufficient aqueous solubility and oral bioavailability. Lipid-based drug delivery system (LBDDS- wide ranging designation for formulations containing a dissolved or suspended drug in lipid excipients) is one of the appropriate approach which gained significant popularity due to their ability to deliver poorly water-soluble drugs with improved solubility and oral bioavailability. Conventional LBDDS, including lipid emulsions, suspensions etc. suffer from various drawbacks limiting their widespread commercialization and use. Therefore, solid-state LBDDS fabricated from conventional LBDDS using different types of solid carriers via various solidification methods eliminated some of the various limitations of conventional LBDDS with great stability. The present review provide overview on the various types of solid state lipid based drug delivery systems, different types of solid carriers use in formulation of solid state lipid based drug delivery system, various solidification techniques for conversion of liquid lipid system to solid dosage form, advantages and some practical limitations of lipid based drug delivery system.

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