The nineteenth-century cultural elevation of science puts it in some respects in an analogous position to that previously occupied by religion in marking out Western civilization. Beginning in the nineteenth century in Germany, France, and Britain, there developed a comprehensive cultural investment in the idea of the unity of science, which played a crucial role in taking over this task from religion. In this chapter the political, social, and ideological motivations behind the nineteenth-century advocacy of the unity of science are explored. At the same time, it examines the formative moves in the establishment of the unity of science, particularly the attempts of the British Association for the Advancement of Science to regiment the sciences, that is, to decide what to include and what to exclude from the rubric of science, and to order and rank those that it included.