In this chapter, Sarah Langer, Ronny Gey, and Diana Karadzhova-Beyer introduce how empirical investigations of organizational deviations from standards can be conceptualized. They suggest a focused ethnography approach to explore the organizational members’ view on the enactment of standards. The applied research strategy includes qualitative interviews, field observations, diaries, the analysis of documents, and questionnaires. The authors present the studies’ empirical premises and the sampling approach, as well as the process of data gathering and analysis. The chapter prepares methodological ground for the case studies CraneSolutions, MedTech, and MetroEngineers. In this way, the authors also provide guidelines and lessons learned, for instance, for replication studies on organizational deviance from standards in other industrial sectors, for other standards, and for the non-profit sector.