Enhanced interaction of patients' lymphocytes with human dermal microvascular endothelial cell cultures in active Adamantiades-Behcet disease

1996 ◽  
Vol 132 (11) ◽  
pp. 1323-1329 ◽  
Author(s):  
R. Treudler
Keyword(s):  
Endothelial Cell ◽  
Cell Cultures ◽  
Microvascular Endothelial Cell ◽  
Behçet Disease ◽  
Behcet Disease ◽  
Endothelial Cell Cultures ◽  
Microvascular Endothelial

scholarly journals Human adipose tissue endothelial cells promote preadipocyte proliferation

2001 ◽  
Vol 281 (5) ◽  
pp. E1037-E1044 ◽  
Author(s):  
L. J. Hutley ◽  
A. C. Herington ◽  
W. Shurety ◽  
C. Cheung ◽  
D. A. Vesey ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Adipose Tissue ◽  
Endothelial Cell ◽  
Human Adipose Tissue ◽  
Cell Types ◽  
Microvascular Endothelial Cell ◽  
Optimal Functioning ◽  
Energy Store ◽  
Endothelial Cell Cultures ◽  
Microvascular Endothelial

Adipogenesis is preceded by development of a microvascular network, and optimal functioning of adipose tissue as an energy store and endocrine organ is dependent on extensive vascularization. We have examined the role of endothelial cell-derived factors that influence the proliferation of human preadipocytes. Microvascular endothelial cells and preadipocytes were isolated from human omental and subcutaneous adipose tissue biopsies by use of a developed procedure of collagenase digest, immunoselection, and differential trypsinization. Conditioned medium from microvascular endothelial cell cultures promoted the proliferation of preadipocytes ( P = <0.001) and (to a lesser extent) other cell types. No depot-specific differences in mitogenic capacity of microvascular endothelial cell medium or of preadipocyte response were observed. These results indicate that adipose tissue endothelial cells secrete soluble adipogenic factor(s).

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