The Natural History of Dementia in Down's Syndrome

1990 ◽  
Vol 47 (3) ◽  
pp. 263-267 ◽  
Author(s):  
H. M. Evenhuis
Keyword(s):  
Natural History ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
History Of

Late-Life Depressive Disorder in the Community

1995 ◽  
Vol 166 (3) ◽  
pp. 316-319 ◽  
Author(s):  
Rob Van Ojen ◽  
Chris Hooijer ◽  
Dick Bezemer ◽  
Cees Jonker ◽  
Jaap Lindeboom ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Family History ◽  
Psychiatric Illness ◽  
Mental Health Problems ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Late Life ◽  
Late Life Depression ◽  
Stratified Sample ◽  
History Of

BackgroundIn previous studies, dementia was linked to a family history of dementia and Down's syndrome. This study tested the hypothesis that late-life depression accompanied by cognitive impairment in elderly individuals with no history of psychiatric illness is also associated with these family histories.MethodWe investigated an age-stratified sample of 4051 elderly people in the community aged 65–84 (AMSTEL). The relationship between family history (CAMDEX questionnaire) and depression (GMS-AGECAT diagnosis) was studied.ResultsA family history of mental health problems was associated with all subtypes of depression. Family history of dementia was associated with depression in subjects with a psychiatric history, but a family history of Down's syndrome was only associated with the combination of depression and cognitive impairment in subjects with no history of psychiatric illness.ConclusionsThe heritability pattern confirms the concept of a dementia-related subtype of late-life depression.

Mania and Down's Syndrome

1993 ◽  
Vol 162 (6) ◽  
pp. 739-743 ◽  
Author(s):  
Sally-Ann Cooper ◽  
Richard A. Collacott
Keyword(s):  
Learning Disabilities ◽  
Family History ◽  
Affective Disorder ◽  
Clinical Features ◽  
Case Reports ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Atypical Presentation ◽  
Rapid Cycling ◽  
History Of

Until recently, it was considered that Down's syndrome precluded a diagnosis of mania, or gave rise to an atypical presentation. There have been seven case reports of mania in people with Down's syndrome and all these cases are reviewed. The clinical features of mania are noted to be similar to those previously described in individuals with learning disabilities due to other causes. However, all reported cases are male and none has a family history of affective disorder. In two of the seven men reported, the illness followed a rapid cycling pattern. Hypothyroidism and monoamine biochemistry in people with Down's syndrome are discussed in the context of these atypical features.

Significance of Basal ganglia calcification in Down's syndrome

2020 ◽  
Vol 14 (3) ◽  
pp. 103-110
Author(s):  
Lesley Thoms ◽  
Adelola Idowu ◽  
Arjun Nehra ◽  
Asit Biswas
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Basal Ganglia ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Mild Intellectual Disability ◽  
Basal Ganglia Calcification ◽  
Content Type ◽  
Chronic Renal Impairment ◽  
History Of

Purpose There is high incidence of dementia in individuals with Down’s syndrome. Much of the emphasis has been on Alzheimer’s disease as being most prevalent; however, it is apparent that other dementia types are also likely, to which this patient cohort may be predisposed. Specifically, this paper aims to highlight the potential for subcortical dementias in Down’s syndrome, suggesting a role for broader cognitive screening in aging individuals. Design/methodology/approach This paper describes a case of a female with Down’s syndrome and mild intellectual disability who presented with early signs of distinctive cognitive impairment and radiological calcification of the basal ganglia. Findings An active 42-year-old lady, who was mostly independent of activities of daily living and in part-time employment, presented with a three-year history of progressive cognitive deficit, characteristic of subcortical decline. She had no personal or known family history of mental illness, epilepsy or dementia. Routine blood tests showed chronic renal impairment, mild hypocalcaemia and vitamin D deficiency, managed by her GP. CT scan showed only bilateral basal ganglia calcification. Originality/value There is a widespread appreciation for the link between Down’s syndrome and Alzheimer’s disease but lesser consideration of the possibility of subcortical dementias. Given the differential nature and presentation of the two dementias, this case report highlights a need for clinicians to consider both to effectively manage these patients in the longer-term. Screening is discussed as a potential means of achieving this.

scholarly journals Unusual Detection of Tuberculosis in a Woman with Down's Syndrome

2010 ◽  
Vol 13 (1) ◽  
pp. 59-62
Author(s):  
D Pešut ◽  
S Raljević ◽  
Tomić Slijepčević
Keyword(s):  
Respiratory Infections ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Diagnostic Procedures ◽  
First Line ◽  
X Ray ◽  
Recurrent Respiratory Infections ◽  
History Of ◽  
Chest X Ray ◽  
The Right

Unusual Detection of Tuberculosis in a Woman with Down's SyndromeA woman with Down's syndrome (DS) had sub-febrile temperature, nodular/patchy shadows on the chest X-ray over the right pulmonary base, and a history of recurrent respiratory infections. She was pale, asthenic, uncommunicative, mildly anemic and the erythrocyte sedimentation rate was 80/first hour. The tuberculin skin test (TST) PPD3 was negative. Mycobacterium tuberculosis was isolated from oral mucosal brushing, sensitive to the first line anti-tuberculosis drugs. Patients with DS and other mental disabilities need special care and attention during diagnostic procedures for tuberculosis (TB).

Occipital Encephalocele and Early Gestational Hyperthermia

PEDIATRICS ◽  
1981 ◽  
Vol 68 (4) ◽  
pp. 480-483
Author(s):  
Nancy L. Fisher ◽  
David W. Smith
Keyword(s):  
Pacific Northwest ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Prolonged Fever ◽  
Occipital Encephalocele ◽  
Medical Centers ◽  
The Pacific ◽  
History Of

Hyperthermia as a human teratogen has been implicated as one cause for neurulation defects. To determine whether there is an association between early maternal hyperthermia (20 to 28 days' gestation) and isolated occipital encephalocele, record reviews were conducted for the period 1969 through 1979 in three major medical centers in the Pacific Northwest. Control patients consisted of children with Down's syndrome matched for year of birth, sex, and race. Of the 17 patients ascertained with an isolated posterior encephalocele, four (24%) of the mothers gave a history of hyperthermia, due to prolonged fever of at least 1.5 C above normal thermal levels early in gestation. In the control patients and siblings of affected children, no history of maternal hyperthermia was elicited. These data are compatible with the concept that early maternal hyperthermia is one cause in the genesis of isolated occipital encephalocele.

Laryngeal lymphangioma as a cause of respiratory distress in an adult with Down’s syndrome: an extremely rare presentation

2021 ◽  
Vol 14 (1) ◽  
pp. e240130
Author(s):  
Neha Chauhan ◽  
Balaji Ramamourthy ◽  
Manjul Muraleedharan ◽  
Ramandeep Singh Virk
Keyword(s):  
Histopathological Examination ◽  
Down's Syndrome ◽  
Ventilatory Support ◽  
Down’S Syndrome ◽  
Rare Presentation ◽  
Laryngeal Inlet ◽  
Plasma Ablation ◽  
History Of ◽  
Nose And Throat

A 32-year-old man with Down’s syndrome was referred to the ear, nose and throat (ENT) department in view of failed attempts at extubation, and subsequently, at decannulation of tracheotomy tube. He had previously required ventilatory support and had history of intubation for 1 week. A flexible fibre-optic laryngoscopy showed a smooth mass covering the laryngeal inlet which moved with respiration. Direct laryngoscopy under general anaesthesia revealed a smooth mucosa covered fleshy mass arising from the left aryepiglottic fold and arytenoid, obstructing the laryngeal inlet. The mass was removed using controlled plasma ablation, and histopathological examination of the same was consistent with lymphangioma. Endoscopic examinations during the regular follow-up visits revealed well-healed supraglottic area with adequate glottic chink and the patient could be successfully decannulated.

The skin and its manifestations in the clinical history of children with Down's syndrome

2011 ◽  
Vol 15 (2) ◽  
pp. 23-25 ◽  
Author(s):  
M.D. Pozo Cano ◽  
E. González Jiménez ◽  
J. Álvarez Ferre ◽  
E. Martínez García ◽  
M.C. Navarro Jiménez
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Clinical History ◽  
History Of

scholarly journals INCLUSÃO DE CRIANÇAS COM SÍNDROME DE DOWN: UM ENSAIO TEÓRICO SOBRE A IMPORTÂNCIA DA RELAÇÃO FAMÍLIA-ESCOLA

2022 ◽  
Vol 18 (1) ◽  
pp. 196-208
Author(s):  
Luana Pereira de Novais Silva ◽  
Jhenifer Prescilla Dias Fuzinelli ◽  
Rosemary Aparecida de Almeida Moraes ◽  
Fabiana Frolini Marques Mangili
Keyword(s):  
Down Syndrome ◽  
Scientific Literature ◽  
Down's Syndrome ◽  
People With Disabilities ◽  
Down’S Syndrome ◽  
Children With Down Syndrome ◽  
Inclusion Process ◽  
The Family ◽  
History Of ◽  
Barriers And Challenges

Faced with the theme of inclusion, discussions about the importance of the family-school relationship are relevant with regard to the socialization of children with Down Syndrome. In this perspective, the main objective of this essay was to explore the scientific literature about the challenges faced by parents, family and teachers in the process of inclusion of children with Down syndrome. Specifically, this article sought to propose discussions on the importance of community awareness and collaboration to change the paradigm of inclusion. Therefore, scientific articles, books and academic papers found in the Google Scholar database were selected, between the period 2011 to 2021, based on the following keywords: People with disabilities; Down's syndrome; Inclusion; History of people with disabilities; Diagnosis of a child with a disability and; Family-School Relationship. Among the main factors influencing the inclusion process of children with Down's Syndrome, beliefs and stigmas of parents, family members, school professionals and society about the child's ability to deal with other people and learn, stand out. family support and the lack of support/guidance from an interdisciplinary team. The inclusion of people with disabilities still faces barriers and challenges that need to be overcome, however, through the active participation of the scientific community and political-social movements, studies on the theme of inclusion show that changes in this scenario have occurred gradually.

How is the moral stance related to the intentional stance and group thinking?

2020 ◽  
Vol 43 ◽  
Author(s):  
Hannes Rakoczy
Keyword(s):  
Natural History ◽  
Social Cognitive ◽  
Intentional Stance ◽  
Cognitive Capacities ◽  
Shared Intentionality ◽  
History Of ◽  
Group Thinking ◽  
Moral Stance

Abstract The natural history of our moral stance told here in this commentary reveals the close nexus of morality and basic social-cognitive capacities. Big mysteries about morality thus transform into smaller and more manageable ones. Here, I raise questions regarding the conceptual, ontogenetic, and evolutionary relations of the moral stance to the intentional and group stances and to shared intentionality.

Sign in / Sign up

Export Citation Format

Share Document