An extracorporeal device to treat barbiturate poisoning. Use of anion-exchange resins in dogs

JAMA ◽  
1966 ◽  
Vol 197 (2) ◽  
pp. 118-120 ◽  
Author(s):  
T. F. Nealon
1999 ◽  
Vol 40 (9) ◽  
pp. 207-214 ◽  
Author(s):  
J.-P. Croué ◽  
D. Violleau ◽  
C. Bodaire ◽  
B. Legube

The objective of this work was to compare the affinity of well characterized NOM fractions isolated from two surface waters with strong (gel matrix and macroporous matrix) and weak anion exchange resins (AER) using batch experiment conditions. The structural characterization of the fraction of NOM has shown that the higher the hydrophilic character, the lower the C/O atomic ratio, the lower the SUVA, the lower the aromatic carbon content and the lower the molecular weight. In general (not always), strong AER was more efficient to remove DOC than weak AER. For the same water source (Suwannee River), the higher the molecular weight of the NOM fraction, the lower the affinity with AER. Increasing the ionic strength favored the removal of the hydrophobic NOM fraction (“salting out” effect) while increasing the pH apparently reduced the removal of the hydrophilic NOM fraction. Results were discussed in terms of size exclusion, adsorption, anion exchange and also hydrophobic/hydrophilic repulsion.


2020 ◽  
pp. 039139882094773
Author(s):  
Karin Strobl ◽  
Stephan Harm ◽  
Ute Fichtinger ◽  
Claudia Schildböck ◽  
Jens Hartmann

Introduction: Heparin and citrate are commonly used anticoagulants in membrane/adsorption based extracorporeal liver support systems. However, anion exchange resins employed for the removal of negatively charged target molecules including bilirubin may also deplete these anticoagulants due to their negative charge. The aim of this study was to evaluate the adsorption of citrate by anion exchange resins and the impact on extracorporeal Ca2+ concentrations. Methods: Liver support treatments were simulated in vitro. Citrate and Ca2+ concentrations were measured pre and post albumin filter as well as pre and post adsorbents. In addition, batch experiments were performed to quantify citrate adsorption. Results: Pre albumin filter target Ca2+ concentrations were reached well with only minor deviations. Citrate was adsorbed by anion exchange resins, resulting in a higher Ca2+ concentration downstream of the adsorbent cartridges during the first hour of treatment. Conclusions: The anion exchange resin depletes citrate, leading to an increased Ca2+ concentration in the extracorporeal circuit, which may cause an increased risk of clotting during the first hour of treatment. An increase of citrate infusion during the first hour of treatment should therefore be considered to compensate for the adsorption of citrate.


2016 ◽  
Vol 75 (6) ◽  
pp. 1309-1318 ◽  
Author(s):  
Ying Wang ◽  
Zhun Li ◽  
Yansheng Li ◽  
Zhigang Liu

Fouled anion exchange resins were regenerated by electric field intensification of Mg/Al double-metal hydroxides. Regenerative experiments were performed with varying voltages (10–30 V) and dosages of Mg/Al hydroxides (0.045–0.135 mol and 0.015–0.045 mol, respectively) for 1–5 h. Optimal results were obtained under the following regenerative conditions: 20 V, 4 h, and 0.09/0.03 mol of Mg/Al hydroxides. The maximum regenerative capacity of resins was increased to 41.07%. The regenerative mechanism was presented by Fourier-transform infrared spectrum of resins and Mg/Al hydroxides, and the regenerative degree was analyzed with respect to conductivity, pH value, and electric current. Mg/Al hydroxides were also recycled after the regeneration. This method was proven to be cost-effective and environmentally friendly.


Energies ◽  
2012 ◽  
Vol 5 (7) ◽  
pp. 2608-2625 ◽  
Author(s):  
Jessica Jones ◽  
Cheng-Han Lee ◽  
James Wang ◽  
Martin Poenie

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