Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus

It has been estimated that currently over 150 million men worldwide suffer from erectile dysfunction (ED) and by 2025, the figure will increase beyond 322 millions. ED is the inability to achieve, and/or maintain penile erection sufficient for satisfactory sexual intercourse, and was previously regarded as the part of aging. It is associated with certain diseases and life style habits with a cause-effect relationship, including diabetes mellitus, hypertension, dyslipidemia, and cigarette smoking. Internationally, most of the men with ED fail to pursue treatment due to the complex nature of sexuality, taboos, cultural restrictions, and acceptance of ED as a normal sequel of aging. In this review, we discussed the physiology, diagnosis, and risk factors associated with ED and current treatment strategies for ED.Keywords: Erectile dysfunction, Diabetes, Penile erection, Phosphodiesterase inhibitors.

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6.22Detecting silent myocardical ischaemia by adenosine stress myocardial perfusion scintigraphy in patients with diabetes mellitus induced erectile dysfunction: preliminary results

Journal of Nuclear Cardiology ◽

10.1016/j.nuclcard.2006.12.175 ◽

2007 ◽

Vol 14 (2) ◽

pp. S44-S44

Author(s):

A ROMEO ◽

G CORONA ◽

M SANTORO ◽

M SCARLATTEI ◽

A BRUNELLI ◽

...

Keyword(s):

Diabetes Mellitus ◽

Erectile Dysfunction ◽

Myocardial Perfusion ◽

Myocardial Perfusion Scintigraphy ◽

Adenosine Stress ◽

Perfusion Scintigraphy ◽

Preliminary Results ◽

Stress Myocardial Perfusion ◽

Patients With Diabetes ◽

Stress Myocardial Perfusion Scintigraphy

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Erectile dysfunction in men with diabetes (literature review) Part 1

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY ◽

10.22141/2224-0721.17.5.2021.241523 ◽

2021 ◽

Vol 17 (5) ◽

pp. 426-434

Author(s):

E.V. Luchytskyy ◽

V.Ye. Luchytskiy

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Risk Factor ◽

Erectile Dysfunction ◽

Rating Scale ◽

Sexual Experience ◽

Clinical Manifestations ◽

Phosphodiesterase Type 5 Inhibitors ◽

Patients With Diabetes

The first part of the review article highlights modern views on the prevalence, etiology and features of the pathogenesis of erectile dysfunction (ED) in men with diabetes mellitus. Google Scholar and PubMed databases were used to search for literature sources. The role of comorbid diseases in the development of ED in men with diabetes mellitus has been shown. The generalized data on the main clinical manifestations of erectile dysfunction, methods of its diagnosis and treatment are given. A number of epidemiological studies over the past 20 years have found that erectile dysfunction in men with diabetes may be an early marker of cardiovascular complications. Thus, in the algorithm for ED diagnosis in patients with diabetes it is necessary to conduct a thorough examination of the cardiovascular system. Numerous literature sources indicate an important role in the correction of androgen deficiency in men with type 2 diabetes, in order to enhance the effectiveness of phosphodiesterase type 5 inhibitors. Erectile dysfunction involves a change in any of the components of an erectile response. ED can negatively affect a man’s quality of life because most patients experience symptoms of depression and anxiety related to their sexual capabilities. These symptoms also affect a partner’s sexual experience and the couple’s quality of life. Clinical features of ED have many key features in the anamnesis, including some physical signs during examination depending on a type of diabetes. With age, comorbid conditions play an increasing role in the development of ED. Diabetes mellitus, cardiovascular diseases, obesity can lead to the development of ED before accelerated deterioration of erectile function and disorders at the molecular level of the mechanisms underlying erection. Patients with diabetes and ED have higher scores on the depression rating scale, and poorer overall health and quality of life. Early detection of ED in individuals with diabetes can improve the overall health and quality of life of patients. Patients with diabetes with poor glycemic control and older age are more likely to develop severe ED, which further exacerbates an already compromised health and quality of life. According to the National Health and Nutrition Examination Survey (2001–2002), diabetes mellitus is a modified risk factor independently associated with the development of ED (odds ratio (OR) 2.69), obesity (OR 1.60), smoking (OR 1.74) and hypertension (OR 1.56). Erectile dysfunction is a common complication of diabetes, and diabetes is a risk factor for ED; men with diabetes are three times more likely to have ED.

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Erectile dysfunction in patients of diabetes mellitus: a cross sectional study

International Surgery Journal ◽

10.18203/2349-2902.isj20193165 ◽

2019 ◽

Vol 6 (8) ◽

pp. 2941

Author(s):

Anilkumar Bellad ◽

Kartik Sahu

Keyword(s):

Diabetes Mellitus ◽

Erectile Dysfunction ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Duration Of Diabetes ◽

Mild Degree ◽

Patients With Diabetes ◽

History Of ◽

One Year

Background: One of the independent risk factor for erectile dysfunction is diabetes mellitus. The present study planned to determine the prevalence and factors associated with ED in DM.Methods: A one year cross-sectional study on a total of 208 patients with type 1 or 2 diabetes. National Institutes of Health (NIH) approved questionnaire for International Index of Erectile Function (IIEF) was used to interview each patient to assess for ED.Results: In this study 12.98% of patients had ED score between 13 to 18 suggestive of mild to moderate ED and 9.62% with 19 to 24 scores suggestive of mild degree. The prevalence of erectile dysfunction was 32.21%. The mean age in patients with erectile dysfunction was significantly high (58.40±10.96 years) compared to those without erectile dysfunction (51.00±11.16 years) (p<0.001) Of the 119 patients with duration of diabetes between one to five years 42.02% had ED and of the 3 patients with duration of more than five years 66.67% had ED (p<0.001). Prevalence of ED was higher in patients with HbA1c levels between 7.0 to 8.5 (32.76%) and >8.5 (37.07%). Prevalence of erectile dysfunction was higher in patients with history of smoking (63.64%) (p<0.001) and alcohol intake (51.85%) (p<0.001). The prevalence of erectile dysfunction was also significantly high in patients with history of hypertension (59.7%) (p<0.001).Conclusions: The ED in patients with diabetes mellitus was significantly prevalent with age, duration of diabetes, history of hypertension, cardiovascular disease, glycemic control and hypertriglyceridemia.

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Current Views on the Treatment Algorithm in Patients with Diabetes Mellitus and Erectile Dysfunction

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY ◽

10.22141/2224-0721.8.80.2016.89544 ◽

2017 ◽

Vol 0 (8.80) ◽

pp. 80-87

Author(s):

N.V. Pasyechko ◽

T.I. Krytskyy ◽

Naumova L.V. ◽

M.A. Dzhula ◽

V.M. Kulchinska

Keyword(s):

Diabetes Mellitus ◽

Erectile Dysfunction ◽

Treatment Algorithm ◽

Patients With Diabetes

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Psycho-sexual Disorders in Clinic Diabetes mellitus Patients of a Teaching Hospital of Eastern Nepal

Journal of Diabetes and Endocrine Association of Nepal ◽

10.3126/jdean.v4i2.34591 ◽

2020 ◽

Vol 4 (2) ◽

pp. 19-23

Author(s):

Dhana Ratna Shakya ◽

R Maskey ◽

P Karki ◽

SK Sharma

Keyword(s):

Diabetes Mellitus ◽

Erectile Dysfunction ◽

Sexual Dysfunction ◽

Teaching Hospital ◽

Sexual Experience ◽

Tertiary Care ◽

Sexual Disorders ◽

Diabetic Patients ◽

Diabetes Clinic ◽

Patients With Diabetes

Background: Diabetes mellitus, a chronic disease, is frequently associated with sexual dysfunctions. Identification and management of these dysfunctions are important for overall wellbeing of the patient, though usually neglected. We lack data on this regard from Nepal. Objective: To estimate prevalence of psycho-sexual disorders (with emphasis on erectile dysfunction) in the patients with diabetes mellitus visiting ‘Diabetes clinic’ of a tertiary care teaching hospital in eastern Nepal. Method: It is a hospital-clinic based prevalence study. This study analyzed consecutive diabetes mellitus clinic patients’ response to self response questionnaires ‘Arizona Sexual Experience Scale’ (ASEX) for over all sexual dysfunction and ‘5- Item Version of the International Index of Erectile Dysfunction’ (IIEF-5) for erectile dysfunction. ‘Diabetes mellitus’ diagnosis was made based on the ADA guidelines 2010. Results: Among 100 male clinic diabetes patients, majorities were married, above age 50 years and all diagnosed as type 2 diabetes mellitus. Out of total, 48% had sexual dysfunction by the ASEX and many subjects had erectile dysfunction by the IIEF-5. Conclusion: Psychosexual dysfunctions, mainly erectile dysfunction are common among diabetic patients. Hence, assessment should include attention to sexual problems as well during management of diabetes mellitus.

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