scholarly journals The relationship between age of onset and risk factors including family history and life style in Korean population with type 2 diabetes mellitus

2018 ◽  
Vol 30 (2) ◽  
pp. 201-206 ◽  
Author(s):  
Jin-Won Noh ◽  
Jin Hee Jung ◽  
Jeong Eun Park ◽  
Jung Hwa Lee ◽  
Kang Hee Sim ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Life Style ◽  
Age Of Onset ◽  
Korean Population ◽  
The Relationship

scholarly journals Life style factors associated with the risk of type 2 diabetes mellitus

2019 ◽  
Vol 1 (2) ◽  
pp. 77-83 ◽  
Author(s):  
Bikash Shrestha ◽  
Bipin Nepal ◽  
Yagya Laxmi Shakya ◽  
Binaya Regmi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Alcohol Use ◽  
Modifiable Risk Factors ◽  
Cross Sectional ◽  
History Of

 Introduction: Type 2 diabetes mellitus is the commonest form of diabetes affecting more than 90% of the diabetic population worldwide. The prevalence of type 2 diabetes and its complications are increasing in the world, including developing nations like Nepal. This study aimed to determine the association between the lifestyle risk factors and the risk of type 2 diabetes mellitus in Nepalese population. Methods: This is hospital based cross sectional observational study done in the urban area of Nepal. Records of clients coming for the general health checkup in Grande International Hospital were evaluated in this study. Comparisons of the lifestyle factors in participants having and not having type 2 diabetes mellitus were done. Results: Significant associations with diagnosis of diabetes mellitus (DM) type 2 were seen in age (P ≤ 0.001), associated hypertension (P ≤ 0.001), dyslipidemia, family history of DM (P ≤ 0.001), alcohol use (P ≤ 0.001), and tobacco use (P ≤ 0.001). Logistic regression analysis showed that the odds of having diabetes were high in age group above 40 (OR – 6.9, CI 3.82 – 12.47), history of hypertension (OR- 3.84, CI 2.42 – 6.08), tobacco users (OR-2.26, CI 1.12 – 4.53), alcohol users (OR-3.99, CI 2.47 – 6.44), family history of DM (OR-2.44, CI 1.53 – 3.89), and abdominal obesity in both males (OR-3.9, CI 2 – 7.4) and females (OR-9.6, CI 3.78 – 24.35). Conclusions: The modifiable risk factors - obesity, smoking and alcohol use carry significant risks of developing type 2 diabetes. These red flag signs call for urgent attention to look for and rectify the modifiable risk factors in Nepalese population to prevent diabetes.

scholarly journals Risk Factors Associated with Diabetes Mellitus in Local Population of Lahore, Pakistan

2017 ◽  
Vol 9 (9) ◽  
pp. 42
Author(s):  
Sana Arshad ◽  
Sania Tahir ◽  
Bilal Tahir ◽  
Nazia Tahir ◽  
Tahir Rasool ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Local Population ◽  
Family History Of Diabetes ◽  
History Of

BACKGROUND: Diabetes is the leading cause of morbidity and mortality amongst the people of Pakistan. In 2015, 7 million people had diabetes and the number is still on raise. Family history of diabetes, high body mass index, and other sociodemographic factors are the risk factors of diabetes. Persistent exposure to excessive glucose may be a reason behind diabetic complications like nephropathy, neuropathy, retinopathy, cardiomyopathy and gestational diabetes mellitus.METHODS: For the evaluation of laboratory parameters, 600 blood samples were collected at Akhuwat Diabetic Centre and from Jinnah Hospital, Lahore. Demographic data of the participants was collected by filling a questionnaire. Lipid profile, liver enzymes, and renal function tests were performed and statistical analysis was done.RESULTS: Type 2 diabetes mellitus among other types is the most prevalent form of diabetes in our population. Family history of diabetes (p=0.002), Body Mass Index (>25) p<0.001, high cholesterol (p=0.04), high triglyceride p<0.001, high LDL p<0.001 and low HDL p<0.001 are significantly associated with the incidence of diabetes. Hypertension among the other comorbidities is more common in diabetic patients.CONCLUSION: Type 2 Diabetes Mellitus is highly prevalent in the local population. Improved lifestyle and proper medical monitoring can help to manage diabetes in our population.

scholarly journals GAMBARAN FAKTOR RESIKO PASIEN DIABETES MELITUS TIPE II Di POLIKLINIK ENDOKRIN BAGIAN/SMF FK-UNSRAT RSU Prof. Dr. R.D KANDOU MANADO PERIODE MEI 2011 - OKTOBER 2011

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Nadyah Awad ◽  
Yuanita A. Langi ◽  
Karel Pandelaki
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Secondary Data ◽  
The Body ◽  
Stage 1 ◽  
Diabetes Melitus

Abstract: Given the high prevalence in patients with type 2 diabetes where the incidence of 650.000 new cases each year. In type-2, the pancreas does not make enough insulin to keep blood sugar levels remain normal, often because the body does not respond well to insulin. Most people do not realize had been suffering from type 2 diabetes, although the situation has become very serious. Type 2 diabetes has become a commonly experienced in the world and in Indonesia, and the numbers continue to grow due to unhealthy lifestyles, obesity and lazy to exercise. Purpose: To determine how the image of risk factors in patients with type 2 diabetes in the clinic Endocrine and Metabolic Section / SMF FK-UNSRAT BLU RSU Prof. Dr. R.D. Manado Kandou the period of May-October2011. Methods: This type of research is a descriptive study using secondary data. Population of type 2 DM patients who come for treatment at the Polyclinic Endocrine and Metabolic Section / SMF FK-UNSRAT BLU RSU Prof.Dr. R.D. Kandou Manado the period of May - October 2011. The number of samples of 138 patients comprising 60 men and 78 women. Result: The case of DM Tiipe 2 in Endocrine and Metabolic Clinic ever found in women than in men. Acquired risk factors for type 2 diabetes mellitus is a BMI> 23 ever found in an obese BMI groups 1 (25-29,9) of 37 patients, patients with stage 1 hypertension (130-159/80-99 mmHg) obtained by 80 patients , patients with dyslipidaemia as many as 22 patients, patients with a family history of as many as 45 patients, patients with age> 40 years as many as 130 patients, and patients who have risk factors for most of the patients with 3 risk factors as many as 74 patients. Conclusion: Risk factors affecting the incidence of type 2 diabetes mellitus in Endocrine and Metabolic Clinic is a BMI> 23, hypertension> 140/90 mmHg, family history,age> 40 years, dyslipidemia. Key words : Risk factors, Diabetes mellitus type 2, Endocrine and Metabolic Clinic.     Abstrak: Mengingat tingginya prevalensi untuk pasien dengan DM tipe 2 dimana insidennya sebesar 650.000 kasus baru tiap tahunnya. Pada tipe-2, pankreas tidak cukup membuat insulin untuk menjaga level gula darah tetap normal, seringkali disebabkan tubuh tidak merespon dengan baik terhadap insulin tersebut. Kebanyakan orang tidak menyadari telah menderita dibetes tipe 2, walaupun keadaannya sudah menjadi sangat serius. Diabetes tipe 2 sudah menjadi umum dialami didunia maupun di Indonesia, dan angkanya terus bertambah akibat gaya hidup yang tidak sehat, kegemukan dan malas berolahraga. Tujuan: Untuk mengetahui bagaimana gambaran faktor risiko pada pasien DM tipe 2 di Poliklinik Endokrin dan Metabolik Bagian/SMF FK-UNSRAT BLU RSU Prof. Dr. R.D. Kandou Manado periode Mei - Oktober 2011. Metode: Jenis penelitian merupakan penelitian deskriptif dengan menggunakan data sekunder. Populasi pasien DM tipe 2 yang datang berobat di Poliklinik Endokrin dan Metabolik Bagian/SMF FK-UNSRAT BLU RSU Prof.Dr. R.D. Kandou Manado periode Mei-Oktober 2011. Jumlah sampel 138 pasien yang terdiri dari 60 laki-laki dan 78 perempuan. Hasil: Kasus DM Tiipe 2 di Poliklinik Endokrin dan Metabolik terbanyak didapatkan pada perempuan dibandingkan pada laki-laki. Faktor risiko yang didapatkan untuk terjadinya DM tipe 2 adalah IMT >23 terbanyak didapatkan pada IMT golongan obes 1 (25-29,9) sebanyak 37 pasien, pasien dengan hipertensi stage 1 (130-159/80-99 mmHg) didapatkan sebanyak 80 pasien, pasien dengan dislipidemia sebanyak 22 pasien, pasien dengan riwayat keluarga sebanyak 45 pasien, pasien dengan umur >40 tahun sebanyak 130 pasien, dan pasien yang memiliki faktor risiko paling banyak adalah pasien dengan tiga faktor risiko yaitu sebanyak 74 pasien. Simpulan: Faktor risiko yang berpengaruh terhadap kejadian DM tipe 2 di Poliklinik Endokrin dan Metabolik adalah IMT >23, hipertensi >140/90 mmHg, riwayat keluarga, umur > 40 tahun, dislipidemia. Kata kunci : Faktor risiko, diabetes melitus tipe 2, Poliklinik Endokrin dan Metabolik.

The Presence of Family History and the Development of Type 2 Diabetes Mellitus Risk Factors in Rural Children

2007 ◽  
Vol 23 (5) ◽  
pp. 259-266 ◽  
Author(s):  
Marsha Howell Adams ◽  
Carol Ann Barnett Lammon
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
School Health ◽  
Family History Of Diabetes ◽  
Health Fairs ◽  
History Of

Type 2 diabetes mellitus is reaching epidemic proportions among children and adolescents. School health fairs offer an opportunity to identify children with risk factors for the development of type 2 diabetes mellitus. This study identified selected risk factors (i.e., high-risk racial/ethnic group, obesity, elevated blood pressure, elevated casual blood glucose, elevated total cholesterol, and the presence of acanthosis nigricans) for development of type 2 diabetes mellitus in rural children with or without a family history of diabetes during annual school health fairs. Of the children screened, 40% (673) presented with two or more of the identified risk factors for type 2 diabetes mellitus. The presence of multiple risk factors in participants reporting a positive family history of diabetes mellitus versus those with no family history was not statistically significant. Based on the study results, factors other than family history may be more predictive for the development of type 2 diabetes mellitus in rural school children.

Abstract P130: Risk Factors for Progression to Type 2 Diabetes Mellitus From Prediabetes

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Margareta Hellgren ◽  
Ulf Lindblad ◽  
Bledar Daka
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Glucose Tolerance

Background and Aims: Individuals with prediabetes, impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT), have approximately 50% risk to develop type 2 diabetes mellitus (T2DM) within ten years. This paper examines risk factors for development of T2DM in individuals with prediabetes. Materials and Methods: A total of 2816 individuals were randomly selected and completed a careful physical examination and an oral glucose tolerance test. IFG and IGT was defined according to WHO. A representative sample of 1327 individuals were re-examined in a follow-up study after ten years. This study focuses on the participants who were diagnosed with prediabetes, IFG (n=67) and/or IGT (n=89) at baseline and who were re-examined at follow-up. Insulin resistance was estimated by HOMA-ir (Homeostatic Model Assessment for Insulin Resistance). Differences between the participants with prediabetes who developed T2DM and those who did not, were analyzed with general linear models and adjusted for age, sex and BMI. The risk to progress to T2DM in ten years was explored using binary logistic regression, adding the risk-factors one after another. Results: Of the 156 individuals with prediabetes 28% progressed to T2DM. Individuals who developed T2DM had higher BMI (α=3.2kg/m 2 , P<0.001), higher HbA1c (α=0.2 mmol/mol, P=0.047), higher C-reactive protein (α=3.3 mmol/L, P=0.040) and also significantly higher HOMAir (α=2.8, P<0.001) at base-line. The risk to develop T2DM increased in a step-wise manner in individuals with prediabetes when successively adding the risk-factors. Having a BMI ≥30kg/m 2 , a known family history for T2DM, HbA1c ≥37mmol/mol, HOMAir ≥2.8 and a low level of physical activity increased the risk to develop T2DM 5.6 times. Table 1. Conclusion: In individuals with prediabetes, those with additional risk-factors like obesity, HbA1c and HOMAir above mean values, family history for T2DM and a low level of physical activity require extra attention and intensive lifestyle interventions should be initiated.

scholarly journals Risk factors for type 2 diabetes mellitus in adolescents secondary school students in Port Harcourt, Nigeria

1970 ◽  
Vol 42 (2) ◽  
pp. 137-141
Author(s):  
T Jaja ◽  
IE Yarhere
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Family History ◽  
Fasting Glucose ◽  
Family History Of Diabetes ◽  
History Of

Background: The prevalence of Type 2 diabetes mellitus (T2 DM) in children and adolescents is on the increase, therefore, prevention and early detection are important.Objective: To assess for easily identifiable risk factors (overweight/obesity, hypertension, Impaired Fasting Glucose (IFG) and family history of diabetes) for T2DM in adolescents in public secondary schoolsResult: Eight hundred and eighty adolescents aged 10 to 19 years were screened and 124(14.1%) were overweight/obese. 457 (51.9%) of students had none of the risk factors while 272(30.9%) had at least one risk factor. Using the American Diabetes Association criteria for identification of those at risk for T2DM, 21(2.4%) were identified. The frequency of presence of risk factors was more in females (3.3%), mid adolescent age group (3.1%) and those with positive family history of diabetes. These findings were however not statistically significant. There was a statistically significant association between presence of hypertension and impaired fasting glucose and risk factor for type 2 DM.Conclusion: The significant risk factors identified in this study were prehypertension/hypertension and impaired fasting blood glucose.Key words: Adolescence, Risk factors, Type 2 diabetes mellitus

scholarly journals Relationship between family history of type 2 diabetes mellitus and knowledge, attitude, and practice regarding type 2 diabetes mellitus among medical students

2021 ◽  
Vol 9 (E) ◽  
pp. 161-166
Author(s):  
Jilan Fachirah ◽  
Mutiara Indah Sari
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medical Students ◽  
Family History ◽  
Attitude And Practice ◽  
History Of ◽  
The Relationship ◽  
Knowledge Attitude And Practice

Abstract BACKGROUND: Diabetes mellitus (DM) is a condition of increase in blood glucose levels, due to impaired synthesis and/or secretion of insulin. Family history of DM is one of the non-modifiable risk factors for someone to suffering DM. Individual knowledge, attitude, and practice towards DM also affects a person to suffering DM. AIM: This study aims to determine the relationship between family history of type 2 diabetes mellitus (T2DM) and knowledge, attitude, and practice regarding T2DM among medical students at the Universitas Sumatera Utara. METHODS: This study was an online questionnaire-based observational study. It was involved 370 medical students from batches of 2017, 2018, and 2019 at the Universitas Sumatera Utara during the period from April-October 2020. Data was collected using a questionnaire containing questions and statements regarding knowledge, attitude, and practice of respondents towards T2DM. The questionnaire also contains questions about respondents' family history of T2DM. The relationship between family history of T2DM and knowledge, attitude, and practice toward T2DM among medical students in the Universitas Sumatera Utara were analyzed using the Chi Square test, with SPSS version 24. RESULTS: From the 370 Universitas Sumatera Utara medical students were being respondents in this study, it was shown that good and poor knowledge scores toward T2DM were 50.8% and 49.2% respectively. The attitude scores were 53.5% and 46.5% respectively. The practice scores were 47.8% and 52.2% respectively. There were 197 students (53.2%) who have a family history of suffering from T2DM and 173 students (46.8%) did not have. The results of the analysis test between data showed that there was a significant relationship between a family history of T2DM with knowledge of T2DM (p = 0.002, RP = 1.921, 95% CI = 1.270-2.906), attitudes (p = 0.005, RP = 1.815, 95% CI = 1.200-2.745) and practice (p = 0.001, RP = 2.092, 95% CI = 1.380-3.173). CONCLUSION: In this study it is shown that the medical students have good knowledge and attitudes towards T2DM but it’s not in line with practice. A family history of T2DM is a factor that influences behavior, attitude, and practice towards T2DM in medical students at the Universitas Sumatera Utara.  

scholarly journals Impact of Genetic Factors on the Age of Onset for Type 2 Diabetes Mellitus in Addition to the Conventional Risk Factors

2020 ◽  
Vol 11 (1) ◽  
pp. 6
Author(s):  
Peter Piko ◽  
Nardos Abebe Werissa ◽  
Szilvia Fiatal ◽  
Janos Sandor ◽  
Roza Adany
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Age Of Onset ◽  
Genetic Risk Score ◽  
Risk Alleles ◽  
Populations At Risk ◽  
Conventional Risk Factors

It is generally accepted that the early detection of type 2 diabetes mellitus (T2DM) is important to prevent the development of complications and comorbidities, as well as premature death. The onset of type 2 diabetes mellitus results from a complex interplay between genetic, environmental, and lifestyle risk factors. Our study aims to evaluate the joint effect of T2DM associated single nucleotide polymorphisms (SNPs) on the age of onset for T2DM in combination with conventional risk factors (such as sex, body mass index (BMI), and TG/HDL-C ratio) in the Hungarian population. This study includes 881 T2DM patients (Case population) and 1415 samples from the Hungarian general population (HG). Twenty-three SNPs were tested on how they are associated with the age of onset for T2DM in the Case population and 12 of them with a certified effect on the age of T2DM onset were chosen for an optimized genetic risk score (GRS) analysis. Testing the validity of the GRS model developed was carried out on the HG population. The GRS showed a significant association with the age of onset for T2DM (β = −0.454, p = 0.001) in the Case population, as well as among T2DM patients in the HG one (β = −0.999, p = 0.003) in the replication study. The higher the GRS, the earlier was the T2DM onset. Individuals with more than eight risk alleles will presumably be diabetic six and a half years earlier than those with less than four risk alleles. Our results suggest that there is a considerable genetic predisposition for the early onset of T2DM; therefore, in addition to conventional risk factors, GRS can be used as a tool for estimating the risk of the earlier onset of T2DM and stratifying populations at risk in order to define preventive interventions.

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