Antibody-Mediated Drug Delivery Systems for Breast Cancer Therapeutics

Nanomedicine contributes to cancer therapeutics in several ways, harnessing some of the remarkable properties of nanomaterials to target tumor cells with increasing specificity. Nano-scale therapeutic strategies enable the simultaneous transport of hydrophilic and hydrophobic drugs across physical and physiological barriers like the blood-brain barrier. Alternative routes of drug administration, such as the intranasal route, have become viable, with more promising therapies for highly lethal tumors like glioblastomas. Cancer nanomedicine allows increased solubility and bioavailability of anti-cancer drugs, reducing their toxicity. Multi-drug delivery systems such as dendrimers, noble metal nanoparticle drug delivery systems, nanoparticle-based theranostics, and nano-biomarkers may well bring about a sea change in cancer therapeutics. This review presents an overview of the scope of cancer nanomedicine, including immunotherapy for cancer.

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Advancements in Cancer Therapeutics

Handbook of Research on Advancements in Cancer Therapeutics - Advances in Medical Diagnosis, Treatment, and Care ◽

10.4018/978-1-7998-6530-8.ch013 ◽

2021 ◽

pp. 382-412

Author(s):

Bilge Bicak ◽

Serda Kecel Gunduz ◽

Aysen E. Ozel

Keyword(s):

Drug Delivery ◽

Cancer Treatment ◽

Targeted Drug Delivery ◽

Drug Delivery Systems ◽

Tumor Antigens ◽

Cancer Therapeutics ◽

Delivery Systems ◽

Molecular Profile ◽

Surface Areas ◽

Targeted Drug

Targeted drug delivery in cancer treatment is a very convenient method for increasing the effectiveness of drugs and reducing their toxic side effects. Nano drug delivery systems have unique physical, chemical, mechanical, and optical properties. Nanoparticles, which have large surface areas and functional groups for the binding of therapeutic agents, benefit the drug distribution with nanoparticle formulations and can provide new features. They also enable personal oncology for diagnosis and treatment, which is appropriate for the personal molecular profile structures of cancer patients. The tumor-targeted active substances are attached to nanoparticles and the active substance loaded nanoparticles are targeted to the tumor area; these nanoparticles can be used with a high tendency to bind and specificity, to target tumor antigens or vessels. This chapter, besides traditional chemotherapy and radiotherapy methods in the field of cancer treatment, is aimed to give information about targeted drug delivery systems for cancer cell targeting without damaging normal tissues.

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Hybrid Vesicular Drug Delivery Systems for Cancer Therapeutics

Advanced Functional Materials ◽

10.1002/adfm.201802136 ◽

2018 ◽

Vol 28 (36) ◽

pp. 1802136 ◽

Cited By ~ 11

Author(s):

Marzieh Mohammadi ◽

Sahar Taghavi ◽

Khalil Abnous ◽

Seyed Mohammad Taghdisi ◽

Mohammad Ramezani ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Cancer Therapeutics ◽

Delivery Systems

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Highly-magnetic mineral protein-tannin vehicles with anti-breast cancer activity

Materials Chemistry Frontiers ◽

10.1039/d0qm00732c ◽

2021 ◽

Author(s):

Polina Demina ◽

Anatolii Abalymov ◽

Denis V. Voronin ◽

Alexander V. Sadovnikov ◽

Maria Vladimirovna Lomova

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Magnetic Nanoparticles ◽

Calcium Carbonate ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Saturation Level ◽

Submicron Particles ◽

Magnetic Mineral ◽

Cancer Activity

Anticancer hybrid mineral highly-magnetic protein-tannin vehicles are tunable and controllable external triggers for drug delivery systems. The saturation level of submicron particles of calcium carbonate with magnetic nanoparticles was achieved....

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