Background:
The Jojoba Simmondsia Chinensis oil is used as one of the main ingredients
which has an antioxidant, moisturizing and stabilizing activity. Likewise, grape seed (Vitis vinifera) oil
is also used in this preparation which also has some remarkable medicinal properties such as antioxidant,
astringent and is also used as a moisturizer. The Valacyclovir Solid Lipid Nanoparticles (SLN)
are prepared in combination.
Objective:
The prime objective of the study was to prepare a nanodispersion with good stability indicating
zeta potential. The formulations were prepared by varying concentrations of jojoba oil and grape
seed oil which form the hybrid nanoparticles with the drug.
Methods:
The high-pressure hot-homogenization technique was used to prepare the nanoparticles. The
prepared nanoparticles were subjected to characterization analysis such as Mean particle size, Zaverage,
and Zeta potential by using Dynamic Light Scattering (DLS) and Photon Correlation Spectroscopy
(PCS). The best formulation was subjected to Transmission Electron Microscopy (TEM)
technique for surface morphology and other characterizations. The crystalline pattern of the drug alone,
drug-loaded nanoparticles and nanoparticles without the drug was studied by XRD. The drug excipients
compatibility studies were performed by using Fourier-Transform Infrared Spectroscopy (FTIR)
Differential Scanning Calorimetry and (DSC). The other factors such as in vitro drug release, and %
drug entrapment efficiency were studied by using suitable methods.
Results:
The results demonstrated that the particles are in nano range with good stability with appreciable
Zeta potential (-48.2±mV). The selected formulations were analyzed for MPS which demonstrated
the value of 306.7±183.4 and 416.5±289.3. The best formulation VNP5 demonstrated the Bellshaped
curve and confirmed the uniform distribution.
Conclusion:
Based on the patents, it was demonstrated that valacyclovir is widely used in the treatment
and prophylaxis of viral infections in human, particularly infections caused by the herpes group
of viruses. Valacyclovir is an effective drug for the treatment of cold sores.
Hybrid Nanoparticles: Design of Hybrid MnO2-Polymer-Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment (Adv. Funct. Mater. 12/2015)