Effective and Selective Anti-Cancer Protein Delivery via All-Functions-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering

2018 ◽  
Vol 28 (14) ◽  
pp. 1706710 ◽  
Author(s):  
Hua He ◽  
Yongbing Chen ◽  
Yongjuan Li ◽  
Ziyuan Song ◽  
Yinan Zhong ◽  
...  
Keyword(s):  
Protein Engineering ◽  
Visible Light ◽  
Protein Delivery ◽  
Anti Cancer

scholarly journals Innenrücktitelbild: Cyclometalated Gold(III)‐Hydride Complexes Exhibit Visible Light‐Induced Thiol Reactivity and Act as Potent Photo‐Activated Anti‐Cancer Agents (Angew. Chem. 27/2020)

2020 ◽  
Vol 132 (27) ◽  
pp. 11252-11252
Author(s):  
Hejiang Luo ◽  
Bei Cao ◽  
Albert S. C. Chan ◽  
Raymond Wai‐Yin Sun ◽  
Taotao Zou
Keyword(s):  
Visible Light ◽  
Hydride Complexes ◽  
Thiol Reactivity ◽  
Anti Cancer

Structural, photoluminescence, electrical, anti cancer and visible light driven photocatalytic characteristics of Co doped WO 3 nanoplates

2017 ◽  
Vol 93 ◽  
pp. 78-89 ◽  
Author(s):  
Faisal Mehmood ◽  
Javed Iqbal ◽  
Tariq Jan ◽  
Asma Gul ◽  
Qaisar Mansoor ◽  
...  
Keyword(s):  
Visible Light ◽  
Anti Cancer ◽  
Visible Light Driven ◽  
Co Doped

Cyclometalated Gold(III)‐Hydride Complexes Exhibit Visible Light‐Induced Thiol Reactivity and Act as Potent Photo‐Activated Anti‐Cancer Agents

2020 ◽  
Vol 132 (27) ◽  
pp. 11139-11145
Author(s):  
Hejiang Luo ◽  
Bei Cao ◽  
Albert S. C. Chan ◽  
Raymond Wai‐Yin Sun ◽  
Taotao Zou
Keyword(s):  
Visible Light ◽  
Hydride Complexes ◽  
Thiol Reactivity ◽  
Anti Cancer

Synthesis of pH-responsive hydrogel thin films grafted on PCL substrates for protein delivery

2015 ◽  
Vol 3 (39) ◽  
pp. 7673-7681 ◽  
Author(s):  
Lihua Zhang ◽  
Yuhong Ma ◽  
Changwen Zhao ◽  
Xing Zhu ◽  
Ruichao Chen ◽  
...  
Keyword(s):  
Thin Films ◽  
Drug Delivery ◽  
Visible Light ◽  
Protein Delivery ◽  
Graft Polymerization ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Polymer Substrates ◽  
Polymerization Method ◽  
Ph Sensitive Hydrogel

A new visible light induced graft polymerization method was utilized to prepare pH-sensitive hydrogel layers covalently attached to polymer substrates for drug delivery.

An efficient visible light controlled protein delivery system

2011 ◽  
Vol 47 (40) ◽  
pp. 11243 ◽  
Author(s):  
Leilei Luo ◽  
Yong Guo ◽  
Juncheng Yang ◽  
Yijun Liu ◽  
Sheng Chu ◽  
...  
Keyword(s):  
Visible Light ◽  
Delivery System ◽  
Protein Delivery

E-waste based graphene oxide/V2O5/Pt ternary composite: Enhanced visible light driven photocatalyst for anti-microbial and anti-cancer activity

2020 ◽  
Vol 607 ◽  
pp. 125469
Author(s):  
Harshavardhan Mohan ◽  
Vaikundamoorthy Ramalingam ◽  
Jeong-Muk Lim ◽  
Se-Won Lee ◽  
Jangho Kim ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Visible Light ◽  
Ternary Composite ◽  
Anti Cancer ◽  
Visible Light Driven ◽  
Cancer Activity

scholarly journals Growth and Proliferation of Renal Cell Carcinoma Cells Is Blocked by Low Curcumin Concentrations Combined with Visible Light Irradiation

2019 ◽  
Vol 20 (6) ◽  
pp. 1464 ◽  
Author(s):  
Jochen Rutz ◽  
Sebastian Maxeiner ◽  
Eva Juengel ◽  
August Bernd ◽  
Stefan Kippenberger ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Visible Light ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Light Exposure ◽  
Epigenetic Mechanism ◽  
Therapeutic Concept ◽  
Apoptotic Protein ◽  
Anti Cancer

The anti-cancer properties of curcumin in vitro have been documented. However, its clinical use is limited due to rapid metabolization. Since irradiation of curcumin has been found to increase its anti-cancer effect on several tumor types, this investigation was designed to determine whether irradiation with visible light may enhance the anti-tumor effects of low-dosed curcumin on renal cell carcinoma (RCC) cell growth and proliferation. A498, Caki1, and KTCTL-26 cells were incubated with curcumin (0.1–0.4 µg/mL) and irradiated with 1.65 J/cm2 visible light for 5 min. Controls were exposed to curcumin or light alone or remained untreated. Curcumin plus light, but not curcumin or light exposure alone altered growth, proliferation, and apoptosis of all three RCC tumor cell lines. Cells were arrested in the G0/G1 phase of the cell cycle. Phosphorylated (p) CDK1 and pCDK2, along with their counter-receptors Cyclin B and A decreased, whereas p27 increased. Akt-mTOR-signaling was suppressed, the pro-apoptotic protein Bcl-2 became elevated, and the anti-apoptotic protein Bax diminished. H3 acetylation was elevated when cells were treated with curcumin plus light, pointing to an epigenetic mechanism. The present findings substantiate the potential of combining low curcumin concentrations and light as a new therapeutic concept to increase the efficacy of curcumin in RCC.

scholarly journals Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Holly A. Rees ◽  
Alexis C. Komor ◽  
Wei-Hsi Yeh ◽  
Joana Caetano-Lopes ◽  
Matthew Warman ◽  
...  
Keyword(s):  
Protein Engineering ◽  
Protein Delivery ◽  
Base Editing ◽  
Dna Specificity
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