Enhancing Osteosarcoma Killing and CT Imaging Using Ultrahigh Drug Loading and NIR‐Responsive Bismuth Sulfide@Mesoporous Silica Nanoparticles

There is a need for the improvement of conventional cancer treatment strategies by incorporation of targeted and non-invasive procedures aimed to reduce side-effects, drug resistance, and recurrent metastases. The anti-cancer drug, 5-fluorouracil (5-FU), is linked to a variety of induced-systemic toxicities due to its lack of specificity and potent administration regimens, necessitating the development of delivery vehicles that can enhance its therapeutic potential, while minimizing associated side-effects. Polymeric mesoporous silica nanoparticles (MSNs) have gained popularity as delivery vehicles due to their high loading capacities, biocompatibility, and good pharmacokinetics. MSNs produced in this study were functionalized with the biocompatible polymers, chitosan, and poly(ethylene)glycol to produce monodisperse NPs of 36–65 nm, with a large surface area of 710.36 m2/g, large pore volume, diameter spanning 9.8 nm, and a favorable zeta potential allowing for stability and enhanced uptake of 5-FU. Significant drug loading (0.15–0.18 mg5FU/mgmsn), controlled release profiles (15–65%) over 72 hours, and cell specific cytotoxicity in cancer cells (Caco-2, MCF-7, and HeLa) with reduced cell viability (≥50%) over the non-cancer (HEK293) cells were established. Overall, these 5FU-MSN formulations have been shown to be safe and effective delivery systems in vitro, with potential for in vivo applications.

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Hollow mesoporous silica nanoparticles for co-delivery of hydrophobic and hydrophilic molecules: mechanism of drug loading and release

Journal of Nanoparticle Research ◽

10.1007/s11051-021-05332-z ◽

2021 ◽

Vol 23 (10) ◽

Author(s):

Fatemeh Kabiri ◽

Soroush Mirfakhraee ◽

Yalda H. Ardakani ◽

Rassoul Dinarvand

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Drug Loading ◽

Hollow Mesoporous Silica

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Effectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA

Materials ◽

10.3390/ma12193202 ◽

2019 ◽

Vol 12 (19) ◽

pp. 3202

Author(s):

Sumita Swar ◽

Veronika Máková ◽

Ivan Stibor

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Drug Loading ◽

Vis Spectroscopy ◽

Bet Analysis ◽

Silica Materials ◽

Different Types ◽

Mesoporous Silica Materials ◽

Drug Vehicle

Our study was focused on the synthesis of selective mesoporous silica nanoparticles (MSNs: MCM-41, MCM-48, SBA-15, PHTS, MCF) that are widely studied for drug delivery. The resulting mesoporous surfaces were conveniently prepared making use of verified synthetic procedures. The MSNs thus obtained were characterized by Brunauer-Emmett-Teller (BET) analysis and scanning electron microscopy (SEM). The selected MSNs with various pore diameters and morphologies were examined to evaluate the capability of L-DOPA drug loading and release. L-DOPA is a well-known drug for Parkinson’s disease. The L-DOPA drug loading and release profiles were measured by UV-VIS spectroscopy and SBA-15 was proved to be the most effective amongst all the different types of tested mesoporous silica materials as L-DOPA drug vehicle.

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Engineering of Hollow Mesoporous Silica Nanoparticles Enhancing Drug-Loading Capacity

IFMBE Proceedings - 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7) ◽

10.1007/978-981-13-5859-3_34 ◽

2019 ◽

pp. 197-201

Author(s):

Ngoc Tram Nguyen Thi ◽

Ngoc Hoang Le ◽

Uyen Vy Vo ◽

Cuu Khoa Nguyen ◽

Dai Hai Nguyen

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Drug Loading ◽

Loading Capacity ◽

Hollow Mesoporous Silica

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Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

RSC Advances ◽

10.1039/c9ra06127d ◽

2019 ◽

Vol 9 (61) ◽

pp. 35566-35578 ◽

Cited By ~ 1

Author(s):

Subhankar Mukhopadhyay ◽

Hanitrarimalala Veroniaina ◽

Tadious Chimombe ◽

Lidong Han ◽

Wu Zhenghong ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Blood Cells ◽

Drug Delivery Systems ◽

Mesoporous Silica Nanoparticles ◽

Drug Loading ◽

Loading Capacity ◽

High Drug ◽

High Drug Loading

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

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Polyethylenimine-mediated synthetic insertion of gold nanoparticles into mesoporous silica nanoparticles for drug loading and biocatalysis

Biointerphases ◽

10.1116/1.4979200 ◽

2017 ◽

Vol 12 (1) ◽

pp. 011005 ◽

Cited By ~ 4

Author(s):

Prem C. Pandey ◽

Govind Pandey ◽

Roger J. Narayan

Keyword(s):

Gold Nanoparticles ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Drug Loading

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Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A

Journal of Pharmacy And Bioallied Sciences ◽

10.4103/0975-7406.94153 ◽

2012 ◽

Vol 4 (5) ◽

pp. 92 ◽

Cited By ~ 22

Author(s):

A Lodha ◽

M Lodha ◽

A Patel ◽

J Chaudhuri ◽

J Dalal ◽

...

Keyword(s):

Mesoporous Silica ◽

Cyclosporin A ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Drug Loading ◽

Water Soluble ◽

Water Soluble Drug ◽

Poorly Water Soluble ◽

Poorly Water Soluble Drug

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Mesoporous Silica Nanoparticles as a Prospective and Promising Approach for Drug Delivery and Biomedical Applications

Current Cancer Drug Targets ◽

10.2174/1568009619666181206114904 ◽

2019 ◽

Vol 19 (4) ◽

pp. 285-295 ◽

Cited By ~ 6

Author(s):

Xiaohui Pu ◽

Jia Li ◽

Peng Qiao ◽

Mengmeng Li ◽

Haiyan Wang ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Biomedical Applications ◽

Mesoporous Silica Nanoparticles ◽

Release Kinetics ◽

Drug Loading ◽

Synthetic Methods ◽

Pubmed Database ◽

Modified Surface

Background: With the development of nanotechnology, nanocarrier has widely been applied in such fields as drug delivery, diagnostic and medical imaging and engineering in recent years. Among all of the available nanocarriers, mesoporous silica nanoparticles (MSNs) have become a hot issue because of their unique properties, such as large surface area and voidage, tunable drug loading capacity and release kinetics, good biosafety and easily modified surface. Objective: We described the most recent progress in silica-assisted drug delivery and biomedical applications according to different types of Cargo in order to allow researchers to quickly learn about the advance in this field. Methods: Information has been collected from the recently published literature available mainly through Title or Abstract search in SpringerLink and PubMed database. Special emphasis is on the literature available during 2008-2017. Results: In this review, the major research advances of MSNs on the drug delivery and biomedical applications were summarized. The significant advantages of MSNs have also been listed. It was found that the several significant challenges need to be addressed and investigated to further advance the applications of these structurally defined nanomaterials. Conclusion: Through approaching this review, the researchers can be aware of many new synthetic methods, smart designs proposed in the recent year and remaining questions of MSNs at present.

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