Live-Cell Imaging of Colloidal Mesoporous Silica Nanoparticles for Drug Delivery: Drug Loading, Pore Sealing and Controlled Release

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

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Tumor targeted delivery of umbelliferone via a smart mesoporous silica nanoparticles controlled-release drug delivery system for increased anticancer efficiency

Materials Science and Engineering C ◽

10.1016/j.msec.2020.111239 ◽

2020 ◽

Vol 116 ◽

pp. 111239 ◽

Cited By ~ 3

Author(s):

Mousumi Kundu ◽

Sharmistha Chatterjee ◽

Noyel Ghosh ◽

Prasenjit Manna ◽

Joydeep Das ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Delivery ◽

Mesoporous Silica Nanoparticles ◽

Release Drug

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Mesoporous Silica Nanoparticles as a Prospective and Promising Approach for Drug Delivery and Biomedical Applications

Current Cancer Drug Targets ◽

10.2174/1568009619666181206114904 ◽

2019 ◽

Vol 19 (4) ◽

pp. 285-295 ◽

Cited By ~ 6

Author(s):

Xiaohui Pu ◽

Jia Li ◽

Peng Qiao ◽

Mengmeng Li ◽

Haiyan Wang ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Biomedical Applications ◽

Mesoporous Silica Nanoparticles ◽

Release Kinetics ◽

Drug Loading ◽

Synthetic Methods ◽

Pubmed Database ◽

Modified Surface

Background: With the development of nanotechnology, nanocarrier has widely been applied in such fields as drug delivery, diagnostic and medical imaging and engineering in recent years. Among all of the available nanocarriers, mesoporous silica nanoparticles (MSNs) have become a hot issue because of their unique properties, such as large surface area and voidage, tunable drug loading capacity and release kinetics, good biosafety and easily modified surface. Objective: We described the most recent progress in silica-assisted drug delivery and biomedical applications according to different types of Cargo in order to allow researchers to quickly learn about the advance in this field. Methods: Information has been collected from the recently published literature available mainly through Title or Abstract search in SpringerLink and PubMed database. Special emphasis is on the literature available during 2008-2017. Results: In this review, the major research advances of MSNs on the drug delivery and biomedical applications were summarized. The significant advantages of MSNs have also been listed. It was found that the several significant challenges need to be addressed and investigated to further advance the applications of these structurally defined nanomaterials. Conclusion: Through approaching this review, the researchers can be aware of many new synthetic methods, smart designs proposed in the recent year and remaining questions of MSNs at present.

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A Review on Application of Multifunctional Mesoporous Nanoparticles in Controlled Release of Drug Delivery

Materials Science Forum ◽

10.4028/www.scientific.net/msf.781.17 ◽

2014 ◽

Vol 781 ◽

pp. 17-24 ◽

Cited By ~ 9

Author(s):

Pragnesh N. Dave ◽

Lakha V. Chopda

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Silica Nanoparticle ◽

Disease Diagnosis ◽

Ammonium Bromide ◽

Composition Material ◽

Mesoporous Silica Nanoparticle

In the early 1990s the discovery of the MCM-41 and the M41S family of mesoporous materials had open new era in the chemistry and biology. They have prominent application inbiotechnological, biomedical and heterogeneous catalysts. Mesoporous silica nanoparticles (MSNs) exhibit unique structural features like as their large surface areas, tunable pore sizes in nanometer and well-defined surface properties. MSN materials which are comprised of a honeycomb-like porous structure with hundreds of empty mesoporous channel that are able to encapsulate relatively large amounts of biomolecules. They are ideal candidate for constructing multifunctional materials that encapsulate a variety of functional nanostructured materials. Multifunctional MSN materials have become one of the most attractive areas in nanobiotechnology and nanomedicine for various disease diagnosis and therapy. Multifunctional MSN have been successfully developed as a multifunctional platform to deliver therapeutic and diagnostic agents. Multifunctional MSNs are a highly promising platform for intracellular controlled release of drugs. In this review we discuss the recent developments in design and fabrication of multifunctional mesoporous silica nanoparticles in as efficient drug delivery applications such as the site-specific delivery and intracellular controlled release of drugs.Abbreviations;APTES; 3-aminopropyl triethoxy sialne, ATP; Adenosine triphospahate, CD; cyclodextrinCPT; camptothecin, CS; Chitosan,CTAB; cyltrimethylammonium bromide,DNA; Deoxyribonucleic acid,DOX; doxorubicin,EDC; 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide,FD; fluorescein disodium,FSP;Fluroscent particle ,IBU;ibuprofen,MCM; mobil composition material, MPS; 3-trimethoxylsilyl propyl methacrylate, MS; mesoporous silica,MSN; mesoporous silica nanoparticle, MSNs; mesoporous silica nanoparticles,MSNP; mesoporous silica nanoparticle,NPS; nanoparticles;PFDTES;perfluorodecyltriethoxysilane, PAA; polyacrylic acid,PR;photo responsive,PMAA; polymethyl methacrylate,SBF; simulated body fluid,TEOS;tetraethyl orthosilicate,TUNA;Thio undecyl-tetraethyleneglycoestero-nitrobenzylethyldimethyl ammonium bromide.

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Galactosylated Chitosan-Functionalized Mesoporous Silica Nanoparticle Loading by Calcium Leucovorin for Colon Cancer Cell-Targeted Drug Delivery

Molecules ◽

10.3390/molecules23123082 ◽

2018 ◽

Vol 23 (12) ◽

pp. 3082 ◽

Cited By ~ 7

Author(s):

Wei Liu ◽

Fan Wang ◽

Yongchao Zhu ◽

Xue Li ◽

Xiaojing Liu ◽

...

Keyword(s):

Drug Delivery ◽

Colon Cancer ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Tumor Cells ◽

Targeted Drug Delivery ◽

Mesoporous Silica Nanoparticles ◽

Drug Loading ◽

Targeted Drug ◽

Galactosylated Chitosan

Targeted drug delivery to colon cancer cells can significantly improve the efficiency of treatment. We firstly synthesized carboxyl-modified mesoporous silica nanoparticles (MSN–COOH) via two-step synthesis, and then developed calcium leucovorin (LV)-loaded carboxyl-modified mesoporous silica nanoparticles based on galactosylated chitosan (GC), which are galectin receptor-mediated materials for colon-specific drug delivery systems. Both unmodified and functionalized nanoparticles were characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR), nitrogen sorption, and dynamic light scattering (DLS). Drug release properties and drug loading capacity were determined by ultraviolet spectrophotometry (UV). LV@MSN–COOH/GC had a high LV loading and a drug loading of 18.07%. In vitro, its release, mainly by diffusion, was sustained release. Cell experiments showed that in SW620 cells with the galectin receptor, the LV@MSN–COOH/GC metabolized into methyl tetrahydrofolic acid (MTHF) and 5-fluorouracil (5-FU)@MSN–NH2/GC metabolized into FdUMP in vivo. MTHF and 5-fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP) had combined inhibition and significantly downregulated the expression of thymidylate synthase (TS). Fluorescence microscopy and flow cytometry experiments show that MSN–COOH/GC has tumor cell targeting, which specifically recognizes and binds to the galectin receptor in tumor cells. The results show that the nano-dosing system based on GC can increase the concentrations of LV and 5-FU tumor cells and enhance their combined effect against colon cancer.

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Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles

Applied Sciences ◽

10.3390/app10010289 ◽

2019 ◽

Vol 10 (1) ◽

pp. 289 ◽

Cited By ~ 4

Author(s):

Kuldeep K. Bansal ◽

Deepak K. Mishra ◽

Ari Rosling ◽

Jessica M. Rosenholm

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Therapeutic Potential ◽

Mesoporous Silica Nanoparticles ◽

Drug Loading ◽

Polymer Coatings ◽

Drug Delivery Carrier ◽

Great Solution ◽

Selection Of

Mesoporous silica nanoparticles (MSNs) find tremendous applications in drug delivery due to several advantages such as their easy fabrication process, high drug loading, biodegradability, biocompatibility, and so forth. Nevertheless, despite several advantages, the use of this striking drug delivery carrier is restricted due to premature drug release owing to the porous structure. Coating of the pores using polymers has emerged as a great solution to this problem. Polymer coatings, which act as gatekeepers, avoid the premature release of loaded content from MSNs and offers the opportunity for controlled and targeted drug delivery. Therefore, in this review, we have compiled the polymer-based coating approaches used in recent years for improving the drug delivery capability of MSNs. This manuscript provides an insight into the research about the potential of polymer-coated MSNs, allowing the selection of right polymer for coating purposes according to the desired application.

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Thermo-Sensitive Nanogated System Based on Polymer-Modified Mesoporous Silica Hybrid Nanoparticles

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.538.93 ◽

2013 ◽

Vol 538 ◽

pp. 93-96

Author(s):

Xin De Tang ◽

Fa Qi Yu ◽

Ye Chen ◽

Mei Shan Pei

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Coupling Reaction ◽

Solid Support ◽

Hybrid Nanoparticles ◽

Chemical Coupling ◽

External Stimuli

Mesoporous silica nanoparticles (MSNs) have been employed as a versatile solid support for constructing a variety of hybrid materials for controlled drug delivery. Controlled release systems that integrate external stimuli with nanocarriers have attracted much attention for sensors and drug delivery applications. Mesoporous silica nanoparticles grafted with thermo-sensitive polymers on the surface were fabricated via “grafting to” approach through chemical coupling reaction. The encapsulation and release of drug based on the thermo-sensitive nanogated system were investigated. The thermo-sensitive nanogated system can be expected as one of the promising candidates for drug delivery and controlled release.

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A pH-responsive mesoporous silica nanoparticles-based drug delivery system with controlled release of andrographolide for OA treatment

Regenerative Biomaterials ◽

10.1093/rb/rbab020 ◽

2021 ◽

Vol 8 (4) ◽

Author(s):

Mingwei He ◽

Zainen Qin ◽

Xiaonan Liang ◽

Xixi He ◽

Bikang Zhu ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Delivery System ◽

Mesoporous Silica Nanoparticles ◽

Cruciate Ligament ◽

Drug Loading ◽

Inflammatory Factors ◽

Ph Responsive

Abstract Andrographolide (AG) has favorable anti-inflammatory and antioxidative capacity. However, it has low bioavailability due to high lipophilicity and can be easily cleared by the synovial fluid after intra-articular injection, leading to low therapeutic efficiency in osteoarthritis (OA). Herein, we designed a nano-sized pH-responsive drug delivery system (DDS) for OA treatment by using modified mesoporous silica nanoparticles (MSNs) with pH-responsive polyacrylic acid (PAA) for loading of AG to form AG@MSNs-PAA nanoplatform. The nanoparticles have uniform size (∼120 nm), high drug loading efficiency (22.38 ± 0.71%) and pH-responsive properties, beneficial to sustained release in OA environment. Compared with AG, AG@MSNs-PAA showed enhanced antiarthritic efficacy and chondro-protective capacity based on IL-1β-stimulated chondrocytes and anterior cruciate ligament transection-induced rat OA model, as demonstrated by lower expression of inflammatory factors and better prevention of proteoglycan loss. Therefore, the AG@MSNs-PAA nanoplatform may be developed as a promising OA-specific and on-demand DDS.

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HOLLOW MESOPOROUS SILICA NANOPARTICLES FABRICATION FOR ANTICANCER DRUG DELIVERY

Vietnam Journal of Science and Technology ◽

10.15625/2525-2518/58/1/14267 ◽

2020 ◽

Vol 58 (1) ◽

pp. 39 ◽

Cited By ~ 1

Author(s):

Ngoc Tram Nguyen Thi ◽

Dai Hai Nguyen

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Anticancer Agents ◽

Pore Volume ◽

Mesoporous Silica Nanoparticles ◽

Drug Loading ◽

High Surface ◽

Loading Capacity ◽

Hollow Mesoporous Silica

Mesoporous silica nanoparticles (MSNs) have attracted significant attention from researchers thanks to their high surface area and pore volume, which can increase drug loading capacity. Moreover, MSNs, with their biocompatibility and ease of surface functionalization, are seen as potential drug delivery system. However, the loading of drug into MSNs system still needs further improvement. In this study, hollow mesoporous silica nanoparticles (HMSNs) were fabricated in order to increase the drug loading capacity of nanosilica materials. The synthesized HMSNs possessed inner hollow cores that could remarkably raise the total pore volume and thus improve the capacity for cargo loading. HMSNs were synthesized according to the hard-template method with three main steps: (1) forming of solid SiO2 nanoparticles as templates, (2) forming of core-shell structure by coating MSN layers onto the templates, and (3) forming of hollow core structure by etching away the solid template. The HMSNs product was characterized by TEM, XRD, TGA and FTIR. In addition, drug loading capacity of the material was evaluated with doxorubicin as model drug. The results indicated remarkable improvement in drug loading capacity, compared to MSN sample. Cell assays on cancer lines showed high biocompatibility. These results demonstrated the potential of HMSNs in the delivery of anticancer agents.

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