Biomimetic Liposome with Surface‐Bound Elastase for Enhanced Tumor Penetration and Chemo‐Immumotherapy

2021 ◽  
pp. 2100794
Author(s):  
Yong‐Jiang Li ◽  
Jun‐Yong Wu ◽  
Xiong‐Bin Hu ◽  
Tianjinhao Ding ◽  
Tiantian Tang ◽  
...  
Keyword(s):  
Tumor Penetration

In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jianqin Yan ◽  
Zhuangzhuang Zhang ◽  
xiaohui Zhan ◽  
Keqi Chen ◽  
Yuji Pu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Deep Penetration ◽  
Tumor Penetration ◽  
Dna Nanostructure ◽  
Promising Strategy

mproving the deep penetration of nanoparticles and realizing the combination of chemotherapy and immunotherapy have become a promising strategy for cancer treatment. Herein, nuclear-targeted tetrahedral DNA nanostructure (NLS-TDNs, NT) was...

A Near-Infrared Laser-Triggered Size-Shrinkable Nanosystem with In Situ Drug Release for Deep Tumor Penetration

2021 ◽  
Author(s):  
Danjun WU ◽  
Shumin Xu ◽  
Xueling Zhang ◽  
Yi Li ◽  
Wangyang Zhang ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Infrared Laser ◽  
Tumor Penetration

scholarly journals Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration

2020 ◽  
pp. 2002589
Author(s):  
Zimu Li ◽  
Xiaoting Shan ◽  
Zhidong Chen ◽  
Nansha Gao ◽  
Wenfeng Zeng ◽  
...  
Keyword(s):  
Surface Modification ◽  
Tumor Penetration

scholarly journals ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer

2019 ◽  
Vol 5 (9) ◽  
pp. eaax2770 ◽  
Author(s):  
Praneeth R. Kuninty ◽  
Ruchi Bansal ◽  
Susanna W. L. De Geus ◽  
Deby F. Mardhian ◽  
Jonas Schnittert ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Tumor Stroma ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
Ductal Adenocarcinoma ◽  
Tumor Penetration ◽  
Desmoplastic Stroma ◽  
Integrin Α5

Abundant desmoplastic stroma is the hallmark for pancreatic ductal adenocarcinoma (PDAC), which not only aggravates the tumor growth but also prevents tumor penetration of chemotherapy, leading to treatment failure. There is an unmet clinical need to develop therapeutic solutions to the tumor penetration problem. In this study, we investigated the therapeutic potential of integrin α5 (ITGA5) receptor in the PDAC stroma. ITGA5 was overexpressed in the tumor stroma from PDAC patient samples, and overexpression was inversely correlated with overall survival. In vitro, knockdown of ITGA5 inhibited differentiation of human pancreatic stellate cells (hPSCs) and reduced desmoplasia in vivo. Our novel peptidomimetic AV3 against ITGA5 inhibited hPSC activation and enhanced the antitumor effect of gemcitabine in a 3D heterospheroid model. In vivo, AV3 showed a strong reduction of desmoplasia, leading to decompression of blood vasculature, enhanced tumor perfusion, and thereby the efficacy of gemcitabine in co-injection and patient-derived xenograft tumor models.

Two‐Stage Size Decrease and Enhanced Photoacoustic Performance of Stimuli‐Responsive Polymer‐Gold Nanorod Assembly for Increased Tumor Penetration

2019 ◽  
Vol 29 (16) ◽  
pp. 1806429 ◽  
Author(s):  
Tianji Liu ◽  
Lingling Tong ◽  
Ningning Lv ◽  
Xiaoguang Ge ◽  
Qinrui Fu ◽  
...  
Keyword(s):  
Gold Nanorod ◽  
Stimuli Responsive ◽  
Two Stage ◽  
Tumor Penetration ◽  
Responsive Polymer ◽  
Stimuli Responsive Polymer

Tumor Penetration of AMSA in Man

1983 ◽  
Vol 1 (6) ◽  
pp. 475-478 ◽  
Author(s):  
Guo Zhengang ◽  
Niramol Savaraj ◽  
Lynn G. Feun ◽  
Katherine Lu ◽  
David J. Stewart ◽  
...  
Keyword(s):  
Tumor Penetration

pH-responsive size-shrinkable mesoporous silica-based nanocarrier for improved tumor penetration and therapeutic efficacy

Nanoscale ◽  
2022 ◽  
Author(s):  
Yongju He ◽  
Xingyu Fan ◽  
Xiaozan Wu ◽  
Taishun Hu ◽  
Fangfang Zhou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Mesoporous Silica ◽  
Therapeutic Efficacy ◽  
Anticancer Therapy ◽  
Major Obstacle ◽  
Drug Penetration ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Promising Strategy

Poor tumor penetration is a major obstacle to nanomedicine for achieving effective anticancer therapy. Tumor microenvironment-induced nanomedicine size shrinkage is a promising strategy to overcome the drug penetration barrier across...

scholarly journals Functional Nanoparticles for Tumor Penetration of Therapeutics

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 193 ◽  
Author(s):  
Yu-Lin Su ◽  
Shang-Hsiu Hu
Keyword(s):  
Therapeutic Efficacy ◽  
Tumor Heterogeneity ◽  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Drug Particle ◽  
Tumor Penetration ◽  
Functional Nanoparticles ◽  
Particle Penetration ◽  
Enhanced Permeability And Retention ◽  
Theranostic Nanoparticles

Theranostic nanoparticles recently received great interest for uniting unique functions to amplify therapeutic efficacy and reduce side effects. Despite the enhanced permeability and retention (EPR) effect, which amplifies the accumulation of nanoparticles at the site of a tumor, tumor heterogeneity caused by the dense extracellular matrix of growing cancer cells and the interstitial fluid pressure from abnormal angiogenesis in the tumor inhibit drug/particle penetration, leading to inhomogeneous and limited treatments. Therefore, nanoparticles for penetrated delivery should be designed with different strategies to enhance efficacy. Many strategies were developed to overcome the obstacles in cancer therapy, and they can be divided into three main parts: size changeability, ligand functionalization, and modulation of the tumor microenvironment. This review summarizes the results of ameliorated tumor penetration approaches and amplified therapeutic efficacy in nanomedicines. As the references reveal, further study needs to be conducted with comprehensive strategies with broad applicability and potential translational development.

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