In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jianqin Yan ◽  
Zhuangzhuang Zhang ◽  
xiaohui Zhan ◽  
Keqi Chen ◽  
Yuji Pu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Deep Penetration ◽  
Tumor Penetration ◽  
Dna Nanostructure ◽  
Promising Strategy

mproving the deep penetration of nanoparticles and realizing the combination of chemotherapy and immunotherapy have become a promising strategy for cancer treatment. Herein, nuclear-targeted tetrahedral DNA nanostructure (NLS-TDNs, NT) was...

scholarly journals Bovine serum albumin-loaded nano-selenium/ICG nanoparticles for highly effective chemo-photothermal combination therapy

RSC Advances ◽  
2017 ◽  
Vol 7 (49) ◽  
pp. 30717-30724 ◽  
Author(s):  
Guanjun Deng ◽  
Ting Zhu ◽  
Lihua Zhou ◽  
Jingnan Zhang ◽  
Sanpeng Li ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Combination Therapy ◽  
Serum Albumin ◽  
Cancer Treatment ◽  
Bovine Serum ◽  
Promising Strategy ◽  
Highly Effective

Chemo-photothermal combination therapy has already become a promising strategy for cancer treatment.

scholarly journals Multifunctional Cargo-Free Nanomedicine for Cancer Therapy

2018 ◽  
Vol 19 (10) ◽  
pp. 2963 ◽  
Author(s):  
Ying Wang ◽  
Pengfei Yang ◽  
Xinrui Zhao ◽  
Di Gao ◽  
Na Sun ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Drug Release ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Clinical Applications ◽  
Self Monitoring ◽  
Promising Strategy ◽  
Carrier Free ◽  
Future Challenges

Nanocarriers encapsulating multiple chemotherapeutics are a promising strategy to achieve combinational chemotherapy for cancer therapy; however, they generally use exotic new carriers without therapeutic effect, which usually suffer from carrier-related toxicity issues, as well as having to pass extensive clinical trials to be drug excipients before any clinical applications. Cargo-free nanomedicines, which are fabricated by drugs themselves without new excipients and possess nanoscale characteristics to realize favorable pharmacokinetics and intracellular delivery, have been rapidly developed and drawn much attention to cancer treatment. Herein, we discuss recent advances of cargo-free nanomedicines for cancer treatment. After a brief introduction to the major types of carrier-free nanomedicine, some representative applications of these cargo-free nanomedicines are discussed, including combination therapy, immunotherapy, as well as self-monitoring of drug release. More importantly, this review draws a brief conclusion and discusses the future challenges of cargo-free nanomedicines from our perspective.

Co-delivery of doxorubicin and methotrexate by dendritic chitosan-g-mPEG as a magnetic nanocarrier for multi-drug delivery in combination chemotherapy

2017 ◽  
Vol 8 (47) ◽  
pp. 7333-7350 ◽  
Author(s):  
Mahdi Rahimi ◽  
Kazem D. Safa ◽  
Roya Salehi
Keyword(s):  
Drug Delivery ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Combination Chemotherapy ◽  
Anticancer Agents ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Synergistic Effects ◽  
Delivery Systems ◽  
Promising Strategy

Nanoparticulate drug delivery systems have the potential to improve the therapeutic efficacy of anticancer agents, and combination therapy is a promising strategy for clinical cancer treatment with synergistic effects.

A metal–phenolic network-based multifunctional nanocomposite with pH-responsive ROS generation and drug release for synergistic chemodynamic/photothermal/chemo-therapy

2020 ◽  
Vol 8 (10) ◽  
pp. 2177-2188 ◽  
Author(s):  
Xiangyu Meng ◽  
Lizhu Chen ◽  
Rongmu Lv ◽  
Mei Liu ◽  
Nongyue He ◽  
...  
Keyword(s):  
Drug Release ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Ros Generation ◽  
Ph Responsive ◽  
Promising Strategy ◽  
Multifunctional Nanomaterials

Developing multifunctional nanomaterials with chemodynamic therapy (CDT)-based combination therapy has increasingly become a promising strategy for cancer treatment.

Design of Novel Photosensitizers and Controlled Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Esra Tanrıverdi Eçik ◽  
Onur BULUT ◽  
Hasan Hüseyin Kazan ◽  
Elif Şenkuytu ◽  
Bunyemin Cosut
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Side Effect ◽  
Side Effect Profile ◽  
High Ability ◽  
Lower Side ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Promising Strategy

Photodynamic therapy (PDT) is a promising strategy in cancer treatment with its relatively lower side effect profile. Undoubtedly, the key component of PDT is the photosensitizers with a high ability...

A Near-Infrared Laser-Triggered Size-Shrinkable Nanosystem with In Situ Drug Release for Deep Tumor Penetration

2021 ◽  
Author(s):  
Danjun WU ◽  
Shumin Xu ◽  
Xueling Zhang ◽  
Yi Li ◽  
Wangyang Zhang ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Infrared Laser ◽  
Tumor Penetration

OCT-Einschweißtiefenüberwachung bei Unterdruck/OCT-based weld penetration monitoring at reduced ambient pressure – Influence of reduced ambient pressure on the OCT signal quality in laser deep penetration welding

2021 ◽  
Vol 111 (11-12) ◽  
pp. 863-868
Author(s):  
Thorsten Mattulat ◽  
Ronald Pordzik ◽  
Peer Woizeschke
Keyword(s):  
Penetration Depth ◽  
Ambient Pressure ◽  
Laser Beam Welding ◽  
In Situ Monitoring ◽  
Deep Penetration ◽  
Weld Penetration ◽  
Laser Deep Penetration Welding ◽  
Deep Penetration Welding ◽  
Non Destructive

Die optische Kohärenztomographie (OCT) erlaubt die zerstörungsfreie In-situ-Überwachung der Einschweißtiefe beim Laserstrahlschweißen. Für dieses Verfahren wird hier der Einfluss von verringerten Umgebungsdrücken auf die Messqualität untersucht. Es wird gezeigt, dass sich bei niedrigerem Umgebungsdruck deutlich größere Signalanteile aus dem Bereich des Bodens der Dampfkapillare zurückerhalten lassen. Auf diese Weise steigen die effektive Messfrequenz und die Erkennbarkeit von Änderungen der Einschweißtiefe.   Optical coherence tomography (OCT) enables non-destructive in-situ monitoring of the weld penetration depth during laser beam welding. For this technology, the influence of reduced ambient pressures on the measurement quality is investigated. It is shown that significantly larger signal components are obtained from the bottom of the vapor capillary at lower ambient pressure increasing the applicable measurement frequency and the detectability of changes in the weld penetration depth.

pH-responsive size-shrinkable mesoporous silica-based nanocarrier for improved tumor penetration and therapeutic efficacy

Nanoscale ◽  
2022 ◽  
Author(s):  
Yongju He ◽  
Xingyu Fan ◽  
Xiaozan Wu ◽  
Taishun Hu ◽  
Fangfang Zhou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Mesoporous Silica ◽  
Therapeutic Efficacy ◽  
Anticancer Therapy ◽  
Major Obstacle ◽  
Drug Penetration ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Promising Strategy

Poor tumor penetration is a major obstacle to nanomedicine for achieving effective anticancer therapy. Tumor microenvironment-induced nanomedicine size shrinkage is a promising strategy to overcome the drug penetration barrier across...

scholarly journals Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy

2018 ◽  
Vol 19 (12) ◽  
pp. 3950 ◽  
Author(s):  
Marilina García-Aranda ◽  
Elisabet Pérez-Ruiz ◽  
Maximino Redondo
Keyword(s):  
Cancer Treatment ◽  
World Health ◽  
Apoptosis Resistance ◽  
Hallmarks Of Cancer ◽  
Cancer Treatments ◽  
Over Expression ◽  
Promising Strategy ◽  
Anti Cancer ◽  
Health Organization

Abstract: According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to overcome resistance to chemo- and immunotherapy.

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