Fast‐Acting Black‐Phosphorus‐Assisted Depression Therapy with Low Toxicity

2019 ◽  
Vol 32 (2) ◽  
pp. 1906050 ◽  
Author(s):  
Liguo Jin ◽  
Ping Hu ◽  
Yinyin Wang ◽  
Luojia Wu ◽  
Kang Qin ◽  
...  
2016 ◽  
Vol 23 (2) ◽  
pp. R131-R142 ◽  
Author(s):  
Carole Guerin ◽  
David Taieb ◽  
Giorgio Treglia ◽  
Thierry Brue ◽  
André Lacroix ◽  
...  

Therapeutic options available for the treatment of Cushing's syndrome (CS) have expanded over the last 5 years. For instance, the efficient management of severe hypercortisolism using a combination of fast-acting steroidogenesis inhibitors has been reported. Recent publications on the long-term efficacy of drugs or radiation techniques have also demonstrated low toxicity. These data should encourage endocrinologists to reconsider the place of bilateral adrenalectomy in patients with ACTH-dependent aetiologies of CS; similarly, the indication of bilateral adrenalectomy is reassessed in primary bilateral macronodular adrenal hyperplasia. The objective of this review is to compare the efficacy and side effects of the various therapeutic options of hypercortisolism with those of bilateral adrenalectomy, in order to better define its indications in the 21st century.


1985 ◽  
Vol 53 (01) ◽  
pp. 122-125 ◽  
Author(s):  
B Åstedt ◽  
Ingegerd Lecander ◽  
T Brodin ◽  
A Lundblad ◽  
Karin Löw

SummaryA monoclonal antibody of IgG2a-type was obtained against a specific fast acting plasminogen activator inhibitor found in placenta. The placental inhibitor was purified by affinity chromatography using the monoclonal antibody and additionally in a FPLC-system. A strong complex formation was found between the inhibitor and urokinase and also with the two-chain form of plasminogen activator of the tissue-type. A weaker complex was found between the placental inhibitor and the one- chain form of the tissue-type activator.


2020 ◽  
Vol 31 (2) ◽  
pp. 83-88 ◽  
Author(s):  
Fernando K. Carvalho ◽  
Rodolfo G. Chechetto ◽  
Alisson A. B. Mota ◽  
Ulisses R. Antuniassi

Crop protection on major crops is now required to follow the principles of integrated pest management so the timing and accuracy of any application of a pesticide or biopesticide has to be more precise to minimize adverse effects on non-target species. The development of UAVs (unmanned aerial vehicles) provides a means of providing a more targeted application of the correct dose, especially by using formulations that are more persistent, thus minimizing loss of spray in areas subject to rain. Avoiding use of too high a dosage allows greater survival of natural enemies and reduces the selection pressure for pests becoming resistant to specific modes of action. The downward flow of air from a UAV should also provide better distribution and impaction of droplets within a crop canopy, reduce soil impaction caused by taking heavy loads of spray applied with 200 l ha–1 of water, and allow treatments when fields are too wet to access with ground equipment. In Asia, many smallholder farmers are using a drone in preference to using a knapsack sprayer. According to Matthews, it has been shown that ULV spraying can be effective, but it needs a narrow droplet spectrum with the droplets remaining stable and not shrinking to become too small. Formulation research can reduce the volatility of the spray, hence the success of oil-based sprays. However, instead of petroleum-based oils, there is a chance to develop vegetable oil carriers with micro-sized particle suspensions to deliver low toxicity pesticides in droplets that can be deposited within the crop and not drift beyond the crop boundary. Oil deposits will be less prone to loss after rain so less should be lost in neighbouring ditches and water courses, especially as rainfall patterns are forecast to change. More studies are needed to evaluate the swath for deposition, buffer zones, formulation, nozzle selection, to guide future specific legislation for UAV applications.


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1037-P
Author(s):  
WENDY LANE ◽  
MAGNUS EKELUND ◽  
ÓLÖF THÓRISDÓTTIR ◽  
ESTEBAN JÓDAR ◽  
ALEJANDRA OVIEDO ◽  
...  

1985 ◽  
Author(s):  
H. SUZUKI ◽  
K. UEMATSU ◽  
K. KURIKI
Keyword(s):  

2020 ◽  
Author(s):  
Morteza Javadi ◽  
Van A. Ortega ◽  
Alyxandra Thiessen ◽  
Maryam Aghajamali ◽  
Muhammad Amirul Islam ◽  
...  

<p>The design and fabrication of Si-based multi-functional nanomaterials for biological and biomedical applications is an active area of research. The potential benefits of using Si-based nanomaterials are not only due to their size/surface-dependent optical responses but also the high biocompatibility and low-toxicity of silicon itself. Combining these characteristics with the magnetic properties of Fe<sub>3</sub>O<sub>4</sub> nanoparticles (NPs) multiplies the options available for real-world applications. In the current study, biocompatible magnetofluorescent nano-hybrids have been prepared by covalent linking of Si quantum dots to water-dispersible Fe<sub>3</sub>O<sub>4</sub> NPs <i>via</i> dicyclohexylcarbodiimide (DCC) coupling. We explore some of the properties of these magnetofluorescent nano-hybrids as well as evaluate uptake, the potential for cellular toxicity, and the induction of acute cellular oxidative stress in a mast cells-like cell line (RBL-2H3) by heat induction through short-term radio frequency modulation (10 min @ 156 kHz, 500 A). We found that the NPs were internalized readily by the cells and also penetrated the nuclear membrane. Radio frequency activated nano-hybrids also had significantly increased cell death where > 50% of the RBL-2H3 cells were found to be in an apoptotic or necrotic state, and that this was attributable to increased triggering of oxidative cell stress mechanisms. </p>


2018 ◽  
Author(s):  
Yingqian Wang ◽  
Xiaoxia Hu ◽  
Lingling Zhang ◽  
Chunli Zhu ◽  
Jie Wang ◽  
...  

Extracellular vesicles (EVs) are involved in the regulation of cell physiological activity and the reconstruction of extracellular environment. Matrix vesicles (MVs) are a type of EVs, and they participate in the regulation of cell mineralization. Herein, bioinspired MVs embedded with black phosphorus are functionalized with cell-specific aptamer (denoted as Apt-bioinspired MVs) for stimulating biomineralization. The aptamer can direct bioinspired MVs to targeted cells, and the increasing concentration of inorganic phosphate originated from the black phosphorus can facilitate cell biomineralization. The photothermal effect of the Apt-bioinspired MVs also positively affects mineralization. In addition, the Apt-bioinspired MVs display outstanding bone regeneration performance. Considering the excellent behavior of the Apt-bioinspired MVs for promoting biomineralization, our strategy provides a way of designing bionic tools for studying the mechanisms of biological processes and advancing the development of medical engineering.<br>


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