Extracellular Matrix in Synthetic Hydrogel‐based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 inhibitors

2021 ◽  
pp. 2100096
Author(s):  
Matthew J Mosquera ◽  
Sungwoong Kim ◽  
Rohan Bareja ◽  
Zhou Fang ◽  
Shuangyi Cai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Extracellular Matrix ◽  
Therapeutic Response ◽  
Synthetic Hydrogel

scholarly journals Extracellular Matrix in Synthetic Hydrogel‐Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors (Adv. Mater. 2/2022)

2022 ◽  
Vol 34 (2) ◽  
pp. 2270014
Author(s):  
Matthew J. Mosquera ◽  
Sungwoong Kim ◽  
Rohan Bareja ◽  
Zhou Fang ◽  
Shuangyi Cai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Extracellular Matrix ◽  
Therapeutic Response ◽  
Synthetic Hydrogel

scholarly journals Mast Cell-Derived SAMD14 is a Novel Regulator of the Human Prostate Tumor Microenvironment

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1237
Author(s):  
Linda K. H. Teng ◽  
Brooke A. Pereira ◽  
Shivakumar Keerthikumar ◽  
Cheng Huang ◽  
Birunthi Niranjan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Extracellular Matrix ◽  
Tumor Microenvironment ◽  
Suppressor Gene ◽  
Prostate Tumor ◽  
Human Prostate ◽  
Proteomic Profiling ◽  
Putative Tumor Suppressor Gene ◽  
Invasion And Migration ◽  
And Migration

Mast cells (MCs) are important cellular components of the tumor microenvironment and are significantly associated with poor patient outcomes in prostate cancer and other solid cancers. The promotion of tumor progression partly involves heterotypic interactions between MCs and cancer-associated fibroblasts (CAFs), which combine to potentiate a pro-tumor extracellular matrix and promote epithelial cell invasion and migration. Thus far, the interactions between MCs and CAFs remain poorly understood. To identify molecular changes that may alter resident MC function in the prostate tumor microenvironment, we profiled the transcriptome of human prostate MCs isolated from patient-matched non-tumor and tumor-associated regions of fresh radical prostatectomy tissue. Transcriptomic profiling revealed a distinct gene expression profile of MCs isolated from prostate tumor regions, including the downregulation of SAMD14, a putative tumor suppressor gene. Proteomic profiling revealed that overexpression of SAMD14 in HMC-1 altered the secretion of proteins associated with immune regulation and extracellular matrix processes. To assess MC biological function within a model of the prostate tumor microenvironment, HMC-1-SAMD14+ conditioned media was added to co-cultures of primary prostatic CAFs and prostate epithelium. HMC-1-SAMD14+ secretions were shown to reduce the deposition and alignment of matrix produced by CAFs and suppress pro-tumorigenic prostate epithelial morphology. Overall, our data present the first profile of human MCs derived from prostate cancer patient specimens and identifies MC-derived SAMD14 as an important mediator of MC phenotype and function within the prostate tumor microenvironment.

scholarly journals ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix

Oncogene ◽  
2006 ◽  
Vol 25 (28) ◽  
pp. 3924-3933 ◽  
Author(s):  
Cs-F Hooi ◽  
C Blancher ◽  
W Qiu ◽  
I M Revet ◽  
L H Williams ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Extracellular Matrix ◽  
Cancer Cells ◽  
Prostate Cancer Cells

Spondin-2, a Secreted Extracellular Matrix Protein, is a Novel Diagnostic Biomarker for Prostate Cancer

2013 ◽  
Vol 190 (6) ◽  
pp. 2271-2277 ◽  
Author(s):  
Giuseppe Lucarelli ◽  
Monica Rutigliano ◽  
Carlo Bettocchi ◽  
Silvano Palazzo ◽  
Antonio Vavallo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Extracellular Matrix ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
Diagnostic Biomarker

401 Loss of LKB1/STK11 expression is an early event in prostate cancer development and predicts therapeutic response to p38α inhibitor

2015 ◽  
Vol 14 (2) ◽  
pp. e401-e401a ◽  
Author(s):  
V. Grossi ◽  
G. Lucarelli ◽  
A. Matrone ◽  
G. Forte ◽  
A. Germani ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Response ◽  
Cancer Development ◽  
Early Event ◽  
Prostate Cancer Development

scholarly journals Androgens modify therapeutic response to cabazitaxel in models of advanced prostate cancer

The Prostate ◽  
2020 ◽  
Vol 80 (12) ◽  
pp. 926-937 ◽  
Author(s):  
Diane Begemann ◽  
Yang Wang ◽  
Wei Yang ◽  
Natasha Kyprianou
Keyword(s):  
Prostate Cancer ◽  
Advanced Prostate Cancer ◽  
Therapeutic Response

Abstract 6204: Prostate cancer exosomes alter extracellular matrix composition in bone marrow and enhance metastasis

2020 ◽  
Author(s):  
Stephen E. Henrich ◽  
Kaylin McMahon ◽  
Michael Plebanek ◽  
Fabio Tavora ◽  
Andre De Souza ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Extracellular Matrix ◽  
Matrix Composition
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