Chronic dapsone use causing methemoglobinemia with oxidative hemolysis and dyserythropoiesis

2021 ◽  
Author(s):  
Christian Aledia Gallardo ◽  
Bingwen Eugene Fan ◽  
Kian Guan Eric Lim ◽  
Ponnudurai Kuperan
Keyword(s):  
Oxidative Hemolysis

scholarly journals Oxidative hemolysis of erythrocytes and its inhibition by free radical scavengers.

1988 ◽  
Vol 263 (36) ◽  
pp. 19809-19814
Author(s):  
E Niki ◽  
E Komuro ◽  
M Takahashi ◽  
S Urano ◽  
E Ito ◽  
...  
Keyword(s):  
Free Radical ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Oxidative Hemolysis

scholarly journals Synthesis and Antioxidant of Some New Pyrazolo[1,5-a]pyrimidine, Pyrazolo[5,1-b]quinazoline and Imidazo[1,2-b]pyrazole Derivatives Incorporating Phenylsulfonyl Moiety

2021 ◽  
Vol 10 (3) ◽  
pp. 2414-2428
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Protective Effects ◽  
Oxidative Hemolysis ◽  
Elemental Analyses ◽  
Phenolic Group ◽  
High Antioxidant Activity ◽  
New Compounds

The synthesis and antioxidant of some new pyrazole analogs were described. It is achieved by the reaction of phenyl-4-(phenylsulfonyl)-1H-pyrazole-3,5-diamine (3) with different bifunctional reagents. The free radical-induced damage and the protective effects of the newly synthesized pyrazoles were studied. These new compounds inhibit the free radical-induced oxidative hemolysis of red blood cells effectively. It was found that these compounds effectively inhibit the free radical-induced oxidative hemolysis of red blood cells. Compound 5, which contain phenolic group, and 17, which bear sulfur, nitrogen atoms, and benzothiazole ring, respectively displayed high antioxidant activity. Analogs 15, 11, 10, and 9 were proved to exhibit antioxidative activity. Structures of new pyrazoles were confirmed by spectroscopic and elemental analyses and have been screened for their antioxidant activity.

Protective Effects of Resveratrol and its Analogues against Free Radical-Induced Oxidative Hemolysis of Red Blood Cells†

2010 ◽  
Vol 20 (11) ◽  
pp. 1313-1318 ◽  
Author(s):  
Jian-Guo Fang ◽  
Man Lu ◽  
Lan-Ping Ma ◽  
Li Yang ◽  
Long-Min Wu ◽  
...  
Keyword(s):  
Free Radical ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Protective Effects ◽  
Oxidative Hemolysis

Antimicrobial, Antioxidant and Antihemolytic Activities of Two Daphne gnidium Leaves Extracts

2021 ◽  
Author(s):  
F. Kaabour ◽  
S. Mezaache-Aichour ◽  
K. Aissat
Keyword(s):  
Phenolic Content ◽  
Ethanolic Extract ◽  
Inhibition Zone ◽  
Total Phenolic ◽  
Bacterial Strains ◽  
Oxidative Hemolysis ◽  
Scavenging Effect ◽  
Daphne Gnidium ◽  
Antibacterial And Antifungal ◽  
Β Carotene

In this study, Daphne gnidium leaves extracts were screened for their Phenolic content, antimicrobial, antioxidant and antihemolitic activities. Decoction and maceration were used to obtain the aqueous (Aq E) and the ethanolic extract (Et E), respectively. Total phenolic content was determined using Folin–Ciocalteu reagent. Moreover, a disc diffusion assay and inhibition of mycelial growth test were applied to evaluate the antibacterial and antifungal activity. The extracts were also tested for their antioxidant effects in terms of DPPH, OH, H2O2, β-carotene, and ferrous ion chelating assays. To investigate antihemolytic activity, the 2,2,-azobis (2-amidinopropane) dihydrochloride (AAPH) was used to induce erythrocyte oxidative hemolysis. Results indicated that ethanolic extract (Et E) contains the highest polyphenol content (775.25 μg GAE/mg extract). The Et E inhibited the growth of bacterial strains with inhibition zone diameters from 7 to 15 mm. In contrast, no activities have been found against all fungal strains. In antihemolytic test, aqueous and ethanolic extracts showed almost the same effect with an HT50 value of 106 min. Ethanolic extract was found to be more active in DPPH and β-carotene assays (IC50: 5.76 μg/ml and 70% inhibition respectively). However, the aqueous extract showed a greater effect than the ethanolic one in metal chelating activity assay (IC50: 170 μg/ml), OH scavenging effect assay (IC50: 9.67 μg/ml) and H2O2 scavenging assay (IC50: 133.2 μg/ml).

scholarly journals Phytochemical Characterization and Bioactive Properties of Cinnamon Basil (Ocimum basilicum cv. ‘Cinnamon’) and Lemon Basil (Ocimum × citriodorum)

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 369 ◽  
Author(s):  
Chaimae Majdi ◽  
Carla Pereira ◽  
Maria Inês Dias ◽  
Ricardo C. Calhelha ◽  
Maria José Alves ◽  
...  
Keyword(s):  
Thiobarbituric Acid ◽  
Positive Control ◽  
Thiobarbituric Acid Reactive Substances ◽  
Oxidative Hemolysis ◽  
Gram Positive Bacteria ◽  
Bioactive Properties ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract ◽  
Derivatives Of

The aim of this work was to contribute to the knowledge on the chemical composition and bioactive properties of two species of the Ocimum genus, namely O. basilicum cultivar ’Cinammon’ and O. × citriodorum. For this purpose, samples of these plants grown in Portugal were evaluated for their composition in phenolic and volatile compounds, and the infusion and hydroethanolic extracts were assessed for their in vitro antioxidant, antimicrobial, cytotoxic, and anti-inflammatory activities. In total, the two basil samples showed the presence of seven caffeic acid and derivatives (dimers, trimers, and tetramers) and five flavonoids, mainly glycoside derivatives of quercetin. Despite some qualitative and quantitative differences, in both samples rosmarinic acid was the major phenolic compound, and linalool the predominant volatile compound. In general, the tested extracts provided relevant bioactive properties since both basil species showed higher antioxidant activity in Thiobarbituric Acid Reactive Substances (TBARs) and Oxidative Hemolysis Inhibition (OxHLIA) assays when compared with the positive control Trolox. Despite O. × citriodorum extracts showing slightly better activity against some strains, both types of extracts evidenced similar antimicrobial activity, being more active against Gram-positive bacteria. The extracts also revealed interesting cytotoxicity, particularly the O. × citriodorum hydroethanolic extract which was also the only one exhibiting anti-inflammatory activity.

scholarly journals Oxidative hemolysis of erythrocytes

2006 ◽  
Vol 34 (6) ◽  
pp. 438-443 ◽  
Author(s):  
Lidia Włodek ◽  
Dorota Kusior
Keyword(s):  
Oxidative Hemolysis

Toxicological screening models: Drug-induced oxidative hemolysis

1983 ◽  
Vol 15 (2-3) ◽  
pp. 153-158 ◽  
Author(s):  
U.A. Boelsterli ◽  
K.P. Shie ◽  
E. Brändle ◽  
G. Zbinden
Keyword(s):  
Toxicological Screening ◽  
Drug Induced ◽  
Oxidative Hemolysis
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