Comorbid chronic rhinosinusitis is not associated with worse asthma control test responses: A case‐control study

2021 ◽  
Author(s):  
Amarbir S. Gill ◽  
Jorgen S. Sumsion ◽  
Heather Howe ◽  
Jeremiah A. Alt
Keyword(s):  
Chronic Rhinosinusitis ◽  
Asthma Control ◽  
Case Control Study ◽  
Case Control ◽  
Control Test ◽  
Asthma Control Test ◽  
Control Study

Impact of Septal Deviation on Recurrent Chronic Rhinosinusitis after Primary Surgery: A Matched Case-Control Study

2018 ◽  
Vol 160 (5) ◽  
pp. 922-927
Author(s):  
Terence Fu ◽  
Daniel Lee ◽  
Jonathan Yip ◽  
Alisha Jamal ◽  
John M. Lee
Keyword(s):  
Chronic Rhinosinusitis ◽  
Case Control Study ◽  
Multivariable Analysis ◽  
Case Control ◽  
Sinus Surgery ◽  
Deviated Nasal Septum ◽  
Primary Surgery ◽  
Academic Center ◽  
The Impact ◽  
Control Study

Objective To evaluate the impact of untreated deviated nasal septum (DNS) on recalcitrant chronic rhinosinusitis (CRS) among patients undergoing revision endoscopic sinus surgery (ESS). Study Design Case-control study. Setting Tertiary academic center. Subjects and Methods We performed a retrospective review of 489 patients undergoing revision ESS for CRS at a tertiary academic center. Patients undergoing septoplasty were matched to nonseptoplasty controls based on age and sex. Preoperative Lund-Mackay score (LMS) was compared between cohorts. Linear regression was used to identify predictors of LMS and ostiomeatal complex (OMC) obstruction. Results Thirty-six matched pairs (72 patients) were selected for analysis: 36 undergoing septoplasty and revision ESS and 36 undergoing revision ESS alone. Compared with nonseptoplasty controls, the septoplasty group had a significantly higher average LMS (17.8 vs 14.6, P = .02) and a greater rate of OMC obstruction (89% vs 61%, P < .01). The septoplasty group also had significantly higher opacification scores in the maxillary (1.5 vs 1.2, P = .03) and posterior ethmoid (1.8 vs 1.4, P = .02) sinuses. On multivariable analysis, DNS was an independent predictor of LMS ( P = .02) and OMC obstruction ( P < .01). Conclusion Untreated DNS is associated with radiographic markers of CRS severity among patients undergoing revision ESS and may contribute to the multifactorial pathogenesis of persistent CRS.

Relative frequencies of symptoms and risk factors among patients with chronic rhinosinusitis with nasal polyps using a case-control study

2017 ◽  
Vol 138 (1) ◽  
pp. 46-49 ◽  
Author(s):  
Anton Bohman ◽  
Martin Oscarsson ◽  
Kenneth Holmberg ◽  
Leif Johansson ◽  
Eva Millqvist ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Establishing Urinary Leukotriene E4 as a Diagnostic Biomarker for Chronic Rhinosinusitis with Comorbid Asthma and Atopy

2019 ◽  
Vol 161 (5) ◽  
pp. 764-769 ◽  
Author(s):  
Griffin D. Santarelli ◽  
Kent K. Lam ◽  
Joseph K. Han
Keyword(s):  
Chronic Rhinosinusitis ◽  
Case Control Study ◽  
Medical Center ◽  
Case Control ◽  
Healthy Controls ◽  
Diagnostic Biomarker ◽  
Tertiary Referral ◽  
Cysteinyl Leukotriene ◽  
Inflammatory State ◽  
Control Study

Objective While urinary leukotriene E4 (uLTE4) is a validated biomarker for the cysteinyl leukotriene pathway, which is central to the pathophysiology of asthma, atopy, and chronic rhinosinusitis (CRS), the contributions of comorbid asthma and atopy to uLTE4 levels in various CRS subtypes have not been previously characterized. We sought to (1) identify reference values for uLTE4 in subjects with and without CRS and (2) determine how the presence of comorbid atopy and asthma affects uLTE4 levels in CRS. Setting Tertiary referral medical center. Subjects and Methods A prospective case-control study was conducted to compare uLTE4 levels between patients with CRS and healthy controls. Urinary LTE4 levels were measured by enzyme immunoassay and were adjusted for urinary creatinine concentrations (pg/mg Cr). Patients with CRS were stratified by the clinical comorbidities to determine normative uLTE4 values for patients with CRS with and without comorbid asthma or atopy. Results A total of 153 patients (mean age, 47.3; 47.1% female) were included in the study. Patients with CRS demonstrated significantly higher concentrations of uLTE4 than healthy controls (1652 vs 1065 pg/mg Cr, P = .032). Within the group of patients with CRS, comorbid asthma also individually correlated with elevated uLTE4 levels (1597 pg/mg Cr, P = .0098). Patients with CRS who did not have comorbid allergy and asthma, in contrast, did not have statistically higher uLTE4 levels than healthy controls (1142 pg/mg Cr, P = .61). Conclusion Urinary LTE4 serves as a noninvasive measure of the inflammatory state in CRS. Comorbid asthma and atopy contribute to elevated uLTE4 levels in CRS.

scholarly journals Chronic rhinosinusitis and premorbid autoimmune diseases: a population-based case–control study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Liang-Chun Shih ◽  
Hua-Hsin Hsieh ◽  
Gregory J. Tsay ◽  
Ivan T. Lee ◽  
Yung-An Tsou ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Chronic Rhinosinusitis ◽  
Large Scale ◽  
Case Control Study ◽  
Comparison Group ◽  
Fungal Infections ◽  
Population Based ◽  
Case Control ◽  
Research Database ◽  
Control Study

Abstract Evidence shows that chronic rhinosinusitis (CRS) is associated with prior presence of autoimmune diseases; however, large-scale population-based studies in the literature are limited. We conducted a population-based case–control study investigating the association between CRS and premorbid autoimmune diseases by using the National Health Insurance Research Database in Taiwan. The CRS group included adult patients newly diagnosed with CRS between 2001 and 2013. The date of diagnosis was defined as the index date. The comparison group included individuals without CRS, with 1:4 frequency matching for gender, age, and index year. Premorbid diseases were forward traced to 1996. Univariate and multivariate logistic regression was performed to estimate odds ratios (ORs) and 95% confidence intervals. The CRS group consisted of 30,611 patients, and the comparison group consisted of 122,444 individuals. Patients with CRS had a higher significant association with premorbid autoimmune diseases (adjusted OR 1.39 [1.28–1.50]). Specifically, patients with CRS had a higher significant association with ankylosing spondylitis, polymyositis, psoriasis, rheumatoid arthritis, sicca syndrome, and systemic lupus erythematosus (adjusted OR 1.49 [1.34–1.67], 3.47 [1.12–10.8], 1.22 [1.04–1.43], 1.60 [1.31–1.96], 2.10 [1.63–2.72], and 1.69 [1.26–2.25]). In subgroup analysis, CRS with and without nasal polyps demonstrated a significant association with premorbid autoimmune diseases (adjusted OR 1.34 [1.14–1.58] and 1.50 [1.38–1.62]). In addition, CRS with fungal and non-fungal infections also demonstrated a significant association with premorbid autoimmune diseases (adjusted OR 2.02 [1.72–2.49] and 1.39 [1.28–1.51]). In conclusion, a significant association between CRS and premorbid autoimmune diseases has been identified. These underlying mechanisms need further investigation.

scholarly journals Case-control study of endoscopic polypectomy in clinic (EPIC) versus endoscopic sinus surgery for chronic rhinosinusitis with polyps

2018 ◽  
Vol 56 (2) ◽  
pp. 155-157 ◽  
Author(s):  
S.J. Kilty ◽  
A. Lasso ◽  
L. Mfuna-Endam ◽  
M.Y. Desrosiers
Keyword(s):  
Chronic Rhinosinusitis ◽  
Endoscopic Sinus Surgery ◽  
Case Control Study ◽  
Case Control ◽  
Sinus Surgery ◽  
Endoscopic Polypectomy ◽  
Control Study

Secondhand tobacco smoke exposure and chronic rhinosinusitis: A population-based case-control study

2009 ◽  
Vol 23 (6) ◽  
pp. 562-567 ◽  
Author(s):  
Douglas D. Reh ◽  
Sandra Y. Lin ◽  
Sandra L. Clipp ◽  
Laili Irani ◽  
Anthony J. Alberg ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Tobacco Smoke ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Secondhand Tobacco Smoke ◽  
Control Study

Gastroesophageal reflux disease increases the risk of chronic rhinosinusitis: a nested case‐control study using a national sample cohort

2018 ◽  
Vol 9 (4) ◽  
pp. 357-362 ◽  
Author(s):  
So Young Kim ◽  
Bumjung Park ◽  
Hyun Lim ◽  
Miyoung Kim ◽  
Il Gyu Kong ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Chronic Rhinosinusitis ◽  
Reflux Disease ◽  
Case Control Study ◽  
National Sample ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

An Association between Acquired Epiphora and the Signs and Symptoms of Chronic Rhinosinusitis: A Prospective Case–Control Study

2003 ◽  
Vol 17 (2) ◽  
pp. 111-114 ◽  
Author(s):  
Sivakumar Annamalai ◽  
N. Ajith Kumar ◽  
M. B. Madkour ◽  
Saraswati Sivakumar ◽  
Haytham Kubba
Keyword(s):  
Chronic Rhinosinusitis ◽  
Case Control Study ◽  
Open Angle Glaucoma ◽  
Signs And Symptoms ◽  
Staging System ◽  
Nasolacrimal Duct ◽  
Case Control ◽  
Consecutive Series ◽  
Control Study ◽  
Prospective Case Control Study

Background It has been suggested that chronic rhinosinusitis may lead to epiphora because of inflammatory edema at the nasal end of the nasolacrimal duct and that treatment of the underlying nasal disease may obviate the need for dacryocys-torhinostomy. The aim of this study was to establish whether or not there is an association between the signs and symptoms of chronic rhinosinusitis and a complaint of epiphora in a blinded, prospective case-control study. Methods A consecutive series of 15 adult patients presenting to the ophthalmology department with acquired epiphora were compared with 29 patients presenting with chronic open-angle glaucoma over the same study period. Nasal symptoms and the findings on nasal endoscopy were recorded by a single otolaryngologist blinded to the diagnosis and using a standardized staging system. Results The age and sex distributions of the two groups were similar. Scores for headache and altered smell were significantly higher in the epiphora cases than in controls (p = 0.05 and 0.03, respectively). Trends for higher scores for congestion and discharge were not statistically significant (p = 0.06 and 0.07, respectively). Mucosal edema and discharge were significantly more common on endoscopy in the epiphora cases than in the control cases (p < 0.02). Conclusion We have shown an association between rhinosinusitis and acquired epiphora, and this would be consistent with chronic rhinosinusitis being the cause of the epiphora in some cases.

scholarly journals The Role of Point-Of-Care CT in the Management of Chronic Rhinosinusitis: A Case-Control Study

2011 ◽  
Vol 90 (8) ◽  
pp. 376-381 ◽  
Author(s):  
David Conley ◽  
Aaron Pearlman ◽  
Kali Zhou ◽  
Rakesh Chandra ◽  
Robert Kern
Keyword(s):  
Chronic Rhinosinusitis ◽  
Case Control Study ◽  
Point Of Care ◽  
Case Control ◽  
Control Study
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