scholarly journals Higher dietary inflammatory index scores are associated with increased incidence of all‐cause dementia in the Framingham Heart Study

2021 ◽  
Vol 17 (S10) ◽  
Author(s):  
Debora Melo van Lent ◽  
Jayandra J Himali ◽  
Hannah Gokingco ◽  
Hugo J Aparicio ◽  
Mitzi M Gonzales ◽  
...  
Keyword(s):  
Framingham Heart Study ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Heart Study

scholarly journals Higher Dietary Inflammatory Index Scores Are Associated With Higher Concentrations of Inflammatory Markers in the Framingham Heart Study

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1059-1059
Author(s):  
Debora Melo van Lent ◽  
Hannah Gokingco ◽  
Emelia Benjamin ◽  
Ramachandran Vasan ◽  
Paul Jacques ◽  
...  
Keyword(s):  
Framingham Heart Study ◽  
Inflammatory Markers ◽  
Inflammatory Marker ◽  
Dietary Factors ◽  
Mediating Effect ◽  
Dietary Inflammatory Index ◽  
Offspring Cohort ◽  
Inflammatory Index ◽  
Heart Study ◽  
Tnf Α

Abstract Objectives We evaluated whether higher (i.e., pro-inflammatory) Dietary Inflammatory Index (DII) scores were associated with increased concentrations of inflammatory markers in the community-based Framingham Heart Study (FHS) Offspring Cohort. Methods We studied 1978 participants (age 61 [SD, 9] years, 53.9% women) from the Offspring cohort who completed a validated 126-item Food Frequency Questionnaire (FFQ) at exam 7 (1998–2001) and at least one of exams 5 (1991–1995) or exam 6 (1995–1998), and on whom inflammatory markers were measured at exam 7. We created a DII score based on the published scoring algorithm by Shivappa et al. 2014, (developed from previous studies linking individual dietary factors to six inflammatory markers); a cumulative DII score was calculated by averaging across a maximum of three FFQs. We used linear regression models to test associations between the cumulative DII score and natural log-transformed concentrations of adiponectin, cluster of differentiation 40 (CD40), C-reactive protein (CRP), fibrinogen, intracellular adhesion molecule (ICAM), interleukin (IL)-6, IL-18, resistin, and TNF-α. Results Higher DII scores were independently associated with higher mean concentrations of four inflammatory markers after adjustment for demographic, clinical, and lifestyle covariates (β± SE, CRP 0.14 mg/L ± 0.04; P < 0.0001, IL-6 0.07 pg/mL ± 0.02; P < 0.003, resistin 0.04 ng/mL ± 0.02 ng/mL; P = 0.01). Exclusion of individuals who smoke currently did not change the results. Additionally, we observed that body mass index had a partially mediating effect on all relationships except the relationships with TNF-α. Further, we observed no significant interactions between higher DII scores and sex in their associations with each inflammatory marker. Conclusions Higher DII scores were associated with higher concentrations of four out of nine inflammatory markers. Our results suggest that anti-inflammatory diets, which correlate with low DII scores may lower systemic chronic inflammation, a process that plays an important role in the development and progression of chronic disease. Funding Sources ASPEN Rhoads Research Foundation and NIH.

Association between Dietary Inflammatory Index and kidney stones in US adults: Data from the NHANES 2007-2016

2021 ◽  
pp. 1-27
Author(s):  
Chichen Zhang ◽  
Shi Qiu ◽  
Haiyang Bian ◽  
Bowen Tian ◽  
Haoyuan Wang ◽  
...  
Keyword(s):  
National Health ◽  
Kidney Stones ◽  
Primary Outcome ◽  
Secondary Outcome ◽  
Nutrition Examination Survey ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Health And Nutrition ◽  
Multivariate Adjustment ◽  
Increased Risk

Abstract Objective: We evaluate the association between the Dietary Inflammatory Index (DII) and kidney stones. Design: We performed a cross-sectional analysis using data from National Health and Nutrition Examination Survey. Dietary intake information was assessed using first 24-HR dietary recall interviews, and the Kidney Conditions was presented by questionnaire. The primary outcome was to investigate the association between DII and incidence of kidney stones, and the secondary outcome was to assess the association between DII and nephrolithiasis recurrence. Setting: The National Health and Nutrition Examination Survey (NHANES), 2007-2016. Participants: The study included 25984 NHANES participants, whose data on DII and kidney stones were available, of whom 2439 reported a history of kidney stones. Results: For the primary outcome, after fully multivariate adjustment, DII score is positively associated with the risk of kidney stones (OR = 1.07; 95% CI: [1.04–1.10]). Then, compared Q4 with Q1, a significant 38% increased likelihood of nephrolithiasis was observed. (OR=1.38; 95% CI: [1.19–1.60]). For the secondary outcome, the multivariate regression analysis showed that DII score is positively correlated with nephrolithiasis recurrence (OR=1.07; 95% CI: [1.00–1.15]). The results noted that higher DII scores (Q3 and Q4) are positively associated with a significant 48% and 61% increased risk of nephrolithiasis recurrence compared with the reference after fully multivariate adjustment. (OR=1.48; 95% CI: [1.07–2.05]; OR=1.61; 95% CI: [1.12–2.31]). Conclusions: Our findings revealed that increased intake of pro-inflammatory diet, as a higher DII score, is correlated with increased odds of kidney stones incidence and recurrence.

scholarly journals The association between the adapted dietary inflammatory index and colorectal cancer recurrence and all-cause mortality

2021 ◽  
Author(s):  
Evertine Wesselink ◽  
Laura E. Staritsky ◽  
Moniek van Zutphen ◽  
Anne J.M.R. Geijsen ◽  
Dieuwertje E. Kok ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Recurrence ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
All Cause Mortality ◽  
Colorectal Cancer Recurrence

scholarly journals Association between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1194
Author(s):  
Vanessa Machado ◽  
João Botelho ◽  
João Viana ◽  
Paula Pereira ◽  
Luísa Bandeira Lopes ◽  
...  
Keyword(s):  
Linear Regression ◽  
Systemic Inflammation ◽  
Mediation Analysis ◽  
White Blood Cells ◽  
Case Definition ◽  
Mediation Effect ◽  
Dietary Inflammatory Index ◽  
Clinical Attachment Loss ◽  
Cross Sectional ◽  
Inflammatory Index

Inflammation-modulating elements are recognized periodontitis (PD) risk factors, nevertheless, the association between dietary inflammatory index (DII) and PD has never been appraised. We aimed to assess the association between DII and PD and the mediation effect of DII in the association of PD with systemic inflammation. Using the National Health and Nutrition Examination Survey 2009–2010, 2011–2012 and 2013–2014, participants who received periodontal exam and provided dietary recall data were included. The inflammatory potential of diet was calculated via DII. PD was defined according to the 2012 case definition. White blood cells (WBC), segmented neutrophils and C-reactive protein (CRP) were used as proxies for systemic inflammation. The periodontal measures were regressed across DII values using adjusted multivariate linear regression and adjusted mediation analysis. Overall, 10,178 participants were included. DII was significantly correlated with mean periodontal probing depth (PPD), mean clinical attachment loss (CAL), thresholds of PPD and CAL, WBC, segmented neutrophils and DII (p < 0.01). A linear regression logistic adjusted for multiple confounding variables confirmed the association between DII and mean PPD (B = 0.02, Standard Error [SE]: 0.02, p < 0.001) and CAL (B = −0.02, SE: 0.01, p < 0.001). The association of mean PPD and mean CAL with both WBC and segmented neutrophils were mediated by DII (from 2.1 to 3.5%, p < 0.001). In the 2009–2010 subset, the association of mean CAL with serum CRP was mediated by DII (52.0%, p < 0.01). Inflammatory diet and PD may be associated. Also, the inflammatory diet significantly mediated the association of leukocyte counts and systemic inflammation with PD.

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