Perivascular space volumes relate to arterial stiffness and cognition

Background: Arterial stiffness aggravation is known to increase cerebral small vessel disease burden. We investigated the association between brachial-ankle pulse wave velocity (baPWV) and the topography of MRI visible perivascular space in acute stroke population. Method: We analyzed clinical and laboratory data of acute ischemic stroke or transient ischemic attack patients who had been admitted to Chung-Ang University Hospital within 7 days after symptom onset between January 1st 2014 and May 31th 2015. We included those patients who underwent both brain MR imaging including T2 weighted sequence and baPWV. The topography of perivascular space was examined in basal ganglia and centrum semiovale level with validating scale (score 0-4), and dichotomized as low (score3). Result: A total of 481 patients were included (mean age 68.2±12.3, 44.7% male). When the distribution of baPWV were divided into quartile, the proportions of high PVS in basal ganglia was 10%, 20%, 40% and 40%, respectively. The proportion of high PVS in centrum semiovale was 20%, 40%, 36%, and 49%, respectively. Multivariate logistic regression analysis revealed that the high degree of basal ganglia PVS was associated with baPWV>2255cm/s (odds ratio 1.7, confidence interval 1.0-2.7, p=0.048) after adjusting age>70 years, hypertension, current smoking status and previous stroke history. The high degree of centrum semiovale PVS showed marginal association with baPWV>2255cm/s (odds ratio=1.4, confidence interval 0.9-2.3, p=0.137) after adjusting age>70 years and hypertension. Conclusion: Our pilot study suggests potential pathophysiological association between arterial stiffness and PVS topography.

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Abstract WP208: Increased Brachial Ankle Pulse Wave Velocity is Associated with Perivascular Space

Stroke ◽

10.1161/str.48.suppl_1.wp208 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Fei-Fei Zhai ◽

Yi-Cong Ye ◽

Si-Yu Chen ◽

Fei Han ◽

Jun Ni ◽

...

Keyword(s):

White Matter ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Small Vessel Disease ◽

Brain Mri ◽

Population Based ◽

Perivascular Space ◽

Arterial Blood

Background and Purpose: To investigate the association between arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), and severity of dilated perivascular space (PVS) in a population-based sample. Methods: Participants were recruited from an ongoing Chinese community-based cohort study. Stroke-free participants, who completed baPWV and brain MRI, were included. Severity of PVS was rated in the basal ganglia (PVS-BG) and white matter (PVS-WM) in high-resolution 3D T1-weighted images. We used logistic regression model to evaluate the association between baPWV and MRI markers. Subsequently, we explored associations in strata of age. Results: A total of 953 participants were included (mean age, 55.7 years, 37.6% male). Age and mean arterial blood pressure were major determinants of baPWV. BaPWV was independently associated with the severity of PVS in white matter (OR per SD,1.39; 95%CI, 1.07-1.81), with periventricular hyperintensities (OR per SD,1.44, 95%CI, 1.10-1.87) and deep white matter hyperintensities (OR per SD,1.44, 95%CI, 1.05-1.97), but not with lacunes. When stratifying by age, baPWV was significantly associated with PVS-WM and PVS-BG only in younger group (age<60), while the association between baPWV and WMH or lacunes was more evident in older group (age≥60). Conclusions: BaPWV was independently associated with severity of PVS, especially in younger individuals. This finding provided further evidences of the relationship between arterial stiffness and cerebral small vessel disease.

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Severe Chronic Plaque Psoriasis Increases Arterial Stiffness Risk

Skin & Allergy News ◽

10.1016/s0037-6337(08)70558-8 ◽

2008 ◽

Vol 39 (8) ◽

pp. 30

Author(s):

BRUCE JANCIN

Keyword(s):

Arterial Stiffness ◽

Plaque Psoriasis ◽

Chronic Plaque Psoriasis

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Arterial stiffness is a potential mechanism and promising indicator of orthostatic hypotension in the general population

VASA ◽

10.1024/0301-1526/a000389 ◽

2014 ◽

Vol 43 (6) ◽

pp. 423-432 ◽

Cited By ~ 11

Author(s):

Qingtao Meng ◽

Si Wang ◽

Yong Wang ◽

Shixi Wan ◽

Kai Liu ◽

...

Keyword(s):

General Population ◽

Arterial Stiffness ◽

Orthostatic Hypotension ◽

Operating Characteristic ◽

Pulse Wave ◽

Augmentation Index ◽

Multiple Logistic Regression Analysis ◽

The Elderly ◽

Baroreceptor Sensitivity ◽

Roc Curve Analysis

Background: Orthostatic hypotension (OH) is a disease prevalent among middle-aged men and the elderly. The association between arterial stiffness and OH is unclear. This study evaluates whether arterial stiffness is correlated with OH and tests the usefulness of brachial-ankle pulse wave velocity (baPWV), an arterial stiffness marker, with regard to identifying OH. Patients and methods: A sample of 1,010 participants was recruited from the general population (64.8 ± 7.7 years; 426 men) who attended health check-ups. BaPWV and the radial augmentation index (rAI) were both assessed as the arterial stiffness markers, and OH was determined using blood pressure (BP) measured in the supine position, as well as 30 seconds and 2 minutes after standing. Results: The prevalence of OH in this population was 4.9 %. Compared with the non-OH group, both baPWV (20.5 ± 4.5 vs 17.3 ± 3.7, p < 0.001) and rAI (88.1 ± 10.8 vs 84.2 ± 10.7, p < 0.05) were significantly higher in the OH group. In the multiple logistic regression analysis, baPWV (OR, 1.3; 95 % CI, 1.106–1.528; p < 0.05) remained associated with OH. Moreover, the degree of orthostatic BP reduction was related to arterial stiffness. In addition, increases in arterial stiffness predicted decreases in the degree of heart rate (HR) elevation. Finally, a receiver operating characteristic (ROC) curve analysis showed that baPWV was useful in discriminating OH (AUC, 0.721; p < 0.001), with the cut-off value of 18.58 m/s (sensitivity, 0.714; specificity, 0.686). Conclusions: Arterial stiffness determined via baPWV, rather than rAI, was significantly correlated with the attenuation of the orthostatic hemodynamic response and the resultant OH. The impaired baroreceptor sensitivity might be the mechanism. In addition, baPWV appears to be a relatively sensitive and reliable indicator of OH in routine clinical practice.

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Markers of arterial stiffness in peripheral arterial disease

VASA ◽

10.1024/0301-1526/a000452 ◽

2015 ◽

Vol 44 (5) ◽

pp. 341-348 ◽

Cited By ~ 25

Author(s):

Marc Husmann ◽

Vincenzo Jacomella ◽

Christoph Thalhammer ◽

Beatrice R. Amann-Vesti

Keyword(s):

Arterial Stiffness ◽

Peripheral Arterial Disease ◽

Pulse Wave ◽

Augmentation Index ◽

Arterial Disease ◽

Care Physician ◽

Additional Information ◽

Non Invasive ◽

Assessment Techniques ◽

Peripheral Arterial

Abstract. Increased arterial stiffness results from reduced elasticity of the arterial wall and is an independent predictor for cardiovascular risk. The gold standard for assessment of arterial stiffness is the carotid-femoral pulse wave velocity. Other parameters such as central aortic pulse pressure and aortic augmentation index are indirect, surrogate markers of arterial stiffness, but provide additional information on the characteristics of wave reflection. Peripheral arterial disease (PAD) is characterised by its association with systolic hypertension, increased arterial stiffness, disturbed wave reflexion and prognosis depending on ankle-brachial pressure index. This review summarises the physiology of pulse wave propagation and reflection and its changes due to aging and atherosclerosis. We discuss different non-invasive assessment techniques and highlight the importance of the understanding of arterial pulse wave analysis for each vascular specialist and primary care physician alike in the context of PAD.

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