Design of Environment-Sensitive Supramolecular Assemblies for Intracellular Drug Delivery: Polymeric Micelles that are Responsive to Intracellular pH Change

2003 ◽  
Vol 115 (38) ◽  
pp. 4788-4791 ◽  
Author(s):  
Younsoo Bae ◽  
Shigeto Fukushima ◽  
Atsushi Harada ◽  
Kazunori Kataoka
Keyword(s):  
Drug Delivery ◽  
Intracellular Ph ◽  
Polymeric Micelles ◽  
Supramolecular Assemblies ◽  
Ph Change ◽  
Intracellular Drug Delivery

Mixed-Charged Zwitterionic Polymeric Micelles for Tumor Acidic Environment Responsive Intracellular Drug Delivery

Langmuir ◽  
2018 ◽  
Vol 35 (5) ◽  
pp. 1242-1248 ◽  
Author(s):  
Zhihui Qin ◽  
Tingting Chen ◽  
Wenzhuo Teng ◽  
Qiao Jin ◽  
Jian Ji
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Acidic Environment ◽  
Intracellular Drug Delivery

Cyclic RGDyK conjugation facilitates intracellular drug delivery of polymeric micelles to integrin-overexpressing tumor cells and neovasculature

2010 ◽  
Vol 19 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Jie Yin ◽  
Zaiquan Li ◽  
Tingyuan Yang ◽  
Jiancheng Wang ◽  
Xuan Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Polymeric Micelles ◽  
Intracellular Drug Delivery

scholarly journals Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics

Polymers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 604 ◽  
Author(s):  
Young Choi ◽  
Eun-sook Choi ◽  
Kwan Mun ◽  
Se Lee ◽  
Sung Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Therapeutic Effects ◽  
Cancer Therapies ◽  
Drug Delivery Vehicles ◽  
Dual Responsive ◽  
Intracellular Drug Delivery ◽  
Efficient Delivery ◽  
Poly Ethylene ◽  
Oxidation Of Methionine

Polymeric micelles as drug delivery vehicles are popular owing to several advantages. In this study, a gemini amphiphile (gemini mPEG-Cys-PMT) consisting of hydrophilic poly(ethylene glycol) and hydrophobic poly(methionine) with cystine disulfide spacer was synthesized and its micellar properties for thiol- or reactive oxygen species (ROS)-dependent intracellular drug delivery were described. The cleavage of cystine linkage in a redox environment or the oxidation of methionine units in a ROS environment caused the destabilization of micelles. Such redox- or ROS-triggered micellar destabilization led to enhanced release of encapsulated doxorubicin (DOX) to induce cytotoxicity against cancer cells. Further, the therapeutic effects of the DOX-loaded micelles were demonstrated using the KB cell line. This study shows that thiol and ROS dual-responsive gemini micelles are promising platforms for nano-drug delivery in various cancer therapies.

Polymeric micelles based on PEGylated chitosan-g-lipoic acid as carrier for efficient intracellular drug delivery

2016 ◽  
Vol 31 (7) ◽  
pp. 1039-1048 ◽  
Author(s):  
Gongyan Liu ◽  
Kaijun Li ◽  
Haibo Wang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lipoic Acid ◽  
Polymeric Micelles ◽  
Drug Carrier ◽  
Intracellular Drug Delivery

To develop a drug delivery system with long circulation and controlled drug release in cancer cells, polymeric micelles based on PEGylated chitosan-g-lipoic acid were prepared to use as a drug delivery platform. These micelles possessed good stability and were stable in physiological environment and high salt concentrations. The in vitro drug release results implied that the drug carrier could maintain their stability and minimize the payload leakage in systemic circulation, but release drugs faster under intracellular redox condition. Furthermore, the cellular uptake and therapeutic efficacy of the drug carrier were evaluated in vitro, and the results demonstrated that the drug carrier could escape from the endo/lysosomes of tumor cells effectively and present high cytotoxicity to tumor cells. Therefore, this drug delivery system has the potential to serve as a drug carrier for cancer therapy.

MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery

2015 ◽  
Vol 51 (3) ◽  
pp. 465-468 ◽  
Author(s):  
Wei-Hai Chen ◽  
Guo-Feng Luo ◽  
Qi Lei ◽  
Hui-Zhen Jia ◽  
Sheng Hong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Cells ◽  
Polymeric Micelles ◽  
Intracellular Drug Delivery

Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were demonstrated to selectively eliminate cancer cells with significantly reduced side effects.

Sign in / Sign up

Export Citation Format

Share Document