Multifunctional Nanoparticles Possessing A ?Magnetic Motor Effect? for Drug or Gene Delivery

2005 ◽  
Vol 117 (7) ◽  
pp. 1092-1095 ◽  
Author(s):  
Tae-Jong Yoon ◽  
Jun Sung Kim ◽  
Byung Geol Kim ◽  
Kyeong Nam Yu ◽  
Myung-Haing Cho ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Multifunctional Nanoparticles ◽  
Motor Effect ◽  
Or Gene

Multifunctional Nanoparticles Possessing A ?Magnetic Motor Effect? for Drug or Gene Delivery

2005 ◽  
Vol 44 (7) ◽  
pp. 1068-1071 ◽  
Author(s):  
Tae-Jong Yoon ◽  
Jun Sung Kim ◽  
Byung Geol Kim ◽  
Kyeong Nam Yu ◽  
Myung-Haing Cho ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Multifunctional Nanoparticles ◽  
Motor Effect ◽  
Or Gene

scholarly journals Multifunctional nanoparticles for drug/gene delivery in nanomedicine

2007 ◽  
Author(s):  
Mary-Margaret Seale ◽  
Dimitry Zemlyanov ◽  
Christy L. Cooper ◽  
Emily Haglund ◽  
Tarl W. Prow ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Multifunctional Nanoparticles

scholarly journals In silico study of PEI-PEG-squalene-dsDNA polyplex formation: The delicate role of PEG length to the binding of PEI to DNA

2021 ◽  
Author(s):  
Tudor Vasiliu ◽  
Bogdan Florin Florin Craciun ◽  
Andrei Neamtu ◽  
Lilia Clima ◽  
Dragos Lucian Isac ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Polyethylene Glycol ◽  
Gene Delivery ◽  
In Silico ◽  
Biomedical Applications ◽  
Experimental Studies ◽  
Biomedical Devices ◽  
In Silico Study ◽  
Or Gene

The biocompatible hydrophilic polyethylene glycol (PEG) is widely used in biomedical applications, such as drug or gene delivery, tissue engineering or as antifouling in biomedical devices. Experimental studies have shown...

scholarly journals Next Generation Delivery System for Proteins and Genes of Therapeutic Purpose: Why and How?

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Ashish Ranjan Sharma ◽  
Shyamal Kumar Kundu ◽  
Ju-Suk Nam ◽  
Garima Sharma ◽  
C. George Priya Doss ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Gene Delivery ◽  
Delivery System ◽  
Delivery Systems ◽  
Therapeutic Protein ◽  
Gene Delivery System ◽  
Next Generation ◽  
Therapeutic Purpose ◽  
Detailed Explanation ◽  
Or Gene

Proteins and genes of therapeutic interests in conjunction with different delivery systems are growing towards new heights. “Next generation delivery systems” may provide more efficient platform for delivery of proteins and genes. In the present review, snapshots about the benefits of proteins or gene therapy, general procedures for therapeutic protein or gene delivery system, and different next generation delivery system such as liposome, PEGylation, HESylation, and nanoparticle based delivery have been depicted with their detailed explanation.

Cationic modified gold nanoparticles show enhanced gene delivery in vitro

2016 ◽  
Vol 5 (5) ◽  
Author(s):  
Geraldine Genevive Lazarus ◽  
Moganavelli Singh
Keyword(s):  
Gene Therapy ◽  
Gold Nanoparticles ◽  
Gene Delivery ◽  
Therapeutic Agent ◽  
Cationic Polymer ◽  
Effective Drug ◽  
Innovative Strategies ◽  
Or Gene

AbstractGold nanoparticles (AuNPs) can be suitably engineered for applications in gene delivery, and as carriers of peptides and proteins. They present innovative strategies in gene therapy for the treatment of genetic as well as acquired diseases. Optimisation of AuNPs in binding and the eventual release of the therapeutic agent in a controlled manner are crucial steps in the pathway to effective drug or gene therapy. In this study, we propose the formulation of cationic polymer [chitosan (Chit) and poly-

Luminescent nanocarriers for simultaneous drug or gene delivery and imaging tracking

2015 ◽  
Vol 73 ◽  
pp. 54-63 ◽  
Author(s):  
Xilin Bai ◽  
Shiguo Wang ◽  
Suying Xu ◽  
Leyu Wang
Keyword(s):  
Gene Delivery ◽  
Or Gene

scholarly journals Nonviral Gene Delivery to Mesenchymal Stem Cells Using Cationic Liposomes for Gene and Cell Therapy

2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
C. Madeira ◽  
R. D. Mendes ◽  
S. C. Ribeiro ◽  
J. S. Boura ◽  
M. R. Aires-Barros ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Gene Delivery ◽  
Cationic Liposome ◽  
Nonviral Gene Delivery ◽  
Great Promise ◽  
Full Potential ◽  
Genetically Engineer ◽  
Or Gene ◽  
First Time

Mesenchymal stem cells (MSCs) hold a great promise for application in several therapies due to their unique biological characteristics. In order to harness their full potential in cell-or gene-based therapies it might be advantageous to enhance some of their features through gene delivery strategies. Accordingly, we are interested in developing an efficient and safe methodology to genetically engineer human bone marrow MSC (BM MSC), enhancing their therapeutic efficacy in Regenerative Medicine. The plasmid DNA delivery was optimized using a cationic liposome-based reagent. Transfection efficiencies ranged from ~2% to ~35%, resulting from using a Lipid/DNA ratio of 1.25 with a transgene expression of 7 days. Importantly, the number of plasmid copies in different cell passages was quantified for the first time and ~20,000 plasmid copies/cell were obtained independently of cell passage. As transfected MSC have shown high viabilities (>90%) and recoveries (>52%) while maintaining their multipotency, this might be an advantageous transfection strategy when the goal is to express a therapeutic gene in a safe and transient way.

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