Polymeric calcium phosphate cements incorporated with poly-γ-glutamic acid: Comparative study of poly-γ-glutamic acid and citric acid

2009 ◽  
Vol 113 (2) ◽  
pp. 1223-1231 ◽  
Author(s):  
Sung Soo Kim ◽  
Mijung Seo ◽  
Jin Wha Chung ◽  
Soon Yong Kwon ◽  
Yong-Sik Kim
2008 ◽  
Vol 396-398 ◽  
pp. 265-268
Author(s):  
Sung Soo Kim ◽  
Sung Jae Lee ◽  
Yong Sik Kim ◽  
Kwon Yong Lee

Polymeric calcium phosphate cements (PCPC) derived from biodegradable poly-g-glutamic acid (g-PGA) were prepared in an attempt to improve the mechanical strength of calcium phosphate cement (CPC). The characteristics of the PCPCs were compared to those of cement incorporated with citric acid. The diametral tensile and compressive strengths of the CPC incorporated with g-PGA were significantly higher than that of cement incorporated with citric acid at equivalent concentrations (p<0.05). The maximal diametral tensile and compressive strengths of the CPC incubated for 1 week in physiological saline solution were approximately 18.0 and 50.0 MPa, respectively. However, the initial setting time of the PCPC was much slower than that of CPC incorporated with citric acid. The formation of ionic complexes between calcium ions and g-PGA was observed using FT-IR spectroscopy. Hydroxyapatite (HA) formation was retarded by g-PGA incorporation according to scanning electronic microscopy (SEM) and powder X-ray diffraction (XRD) observations.


2016 ◽  
Vol 166 ◽  
pp. 341-347 ◽  
Author(s):  
Fidèle Suanon ◽  
Qian Sun ◽  
Biaou Dimon ◽  
Daouda Mama ◽  
Chang-Ping Yu

2021 ◽  
Vol 5 (1) ◽  
pp. 30
Author(s):  
Angelica Bertacci ◽  
Daniele Moro ◽  
Gianfranco Ulian ◽  
Giovanni Valdrè

Recently, endodontic sealers based on injectable bioactive materials were proposed to improve the filling of anatomical irregularities during root canal obturation. In this context, this preliminary work investigated the possibility of realizing a new calcium phosphate-based composite sealer for root canal filling with an optimized composition on setting kinetics and dentin tubules occlusion. Several calcium phosphate/liquid phase mixtures were initially evaluated for their workability, finding two suitable formulations. Both of them contained 66 wt.% of a nano-apatite-based cement (solid powdered phase). The liquid phase (34 wt.%) comprised 13.6% propanediol and 20.4% PEG 1000 (formulation 1), and formulation 2 comprised 27.2% glycerin and 6.8% PEG 200 (formulation 2). Then, these formulations were tested by means of permeability measurements and observation by scanning electron microscopy of treated model dentin samples. Both formulations succeeded in occluding dentinal tubules: the first one was able to create a full-bodied layer on dentin surface and, moreover, to resist, at least to a large extent, against citric acid attack. The second one showed a lower effectiveness after citric acid exposure. The composite compound that better satisfied the overall required characteristics of use, workability and sealing capacity was formulation 1.


Author(s):  
Yu Qu ◽  
Hui Zhuang ◽  
Meng Zhang ◽  
Yufeng Wang ◽  
Dong Zhai ◽  
...  

Although calcium phosphate cements (CPC) have been clinically used to repair bone defects caused by bone tumor resection, traditional CPC cannot kill the remaining tumor cells after surgery and prevent...


2020 ◽  
Vol 23 ◽  
pp. 100901 ◽  
Author(s):  
Irene Lodoso-Torrecilla ◽  
Floris Stumpel ◽  
John A. Jansen ◽  
Jeroen J.J.P. van den Beucken

2009 ◽  
Vol 5 (7) ◽  
pp. 2752-2762 ◽  
Author(s):  
M. Espanol ◽  
R.A. Perez ◽  
E.B. Montufar ◽  
C. Marichal ◽  
A. Sacco ◽  
...  

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