scholarly journals Relationship between arthroscopic evidence of cartilage damage and radiographic evidence of joint space narrowing in early osteoarthritis of the knee

1991 ◽  
Vol 34 (4) ◽  
pp. 377-382 ◽  
Author(s):  
Rose S. Fife ◽  
Kenneth D. Brandt ◽  
Ethan M. Braunstein ◽  
Barry P. Katz ◽  
K. Donald Shelbourne ◽  
...  
Keyword(s):  
Joint Space Narrowing ◽  
Cartilage Damage ◽  
Joint Space ◽  
Osteoarthritis Of The Knee ◽  
Early Osteoarthritis ◽  
Radiographic Evidence

scholarly journals Intra-Articular Pressure in Osteoarthritis of the Knee

2020 ◽  
Author(s):  
kai niu ◽  
le hai Pan
Keyword(s):  
Joint Space Narrowing ◽  
Normal Subjects ◽  
Joint Space ◽  
Positive Pressure ◽  
Osteoarthritis Of The Knee ◽  
Research Subjects ◽  
Pressure Profiles ◽  
Control Knee ◽  
Group 2 ◽  
The Relationship

Abstract Background: IAP （intra-articular pressure）of the knee has been extensively studied in the knee of rheumatoid arthritis1.3 . the relationship between IAP and osteoarthrosis of knee rarely mentioned in the literature. The purpose of the study was to discover the pressure profiles observed in OA(Osteoarthritis ）. The characteristics of osteoarthritis are multiple osteophytes, unstable chondral flaps ,joint-space narrowing，sclerosis. Whether these factors effect of osteoarthritis intra-articular pressure.Methods: Fifty three research subjects were studied. They were divided into two subgroups, group 1: Forty osteoarthritis (OA). group 2: Thirteen control knee of healthy volunteer. IAP was measured using the hand held portable water manometer. before operation of arthroscopic procedures in OAgroup . Research data were analyzed to identify IAP between the two groups. Results: The main findingwasthat Resting IAP was positive pressure in all Osteoarthritis joints, otherwise subatmospheric or weakly atmospheric in normal subjects. Conclusions: The IAP rising is a feature of all patients with OAgroup. Therefore, These observations we recognize that significantly increased resting IAP is major influences by multiple osteophytes, joint-space narrowing，sclerosis , loose bodies and definite deformity of bony ends.

Internal splinting of dorsal intertarsal and tarsometatarsal instabilities in dogs and cats with the ComPact UniLock 2.0/2.4TM System

2004 ◽  
Vol 17 (03) ◽  
pp. 125-130 ◽  
Author(s):  
M. Keller ◽  
P. M. Montavon ◽  
K. Voss
Keyword(s):  
Joint Space Narrowing ◽  
Cartilage Damage ◽  
Joint Space ◽  
Joint Function ◽  
Partial Arthrodesis ◽  
Joint Fusion ◽  
One Year ◽  
The Stability ◽  
Prolonged Immobilization

SummaryDorsal intertarsal and tarsometatarsal instabilities are considered to be uncommon in dogs and only a few cases have been reported in cats. Treatment usually consists at partial arthrodesis. Internal splinting of the affected joints represents an alternative surgical method, with the goal of preserving joint function. In the present study, 13 animals (10 cats and 3 dogs) with dorsal, dorsomedial or dorsolateral intertarsal or tarsometatarsal instabilities, treated with an internal fixator (ComPact UniLock 2.0/2.4™ System) in bridging function, were reviewed. The joint cartilage was left intact. Follow-up time ranged from one month to one year postoperatively. The clinical outcome was considered good or excellent in 12 of the animals and moderate in one cat. The implants were removed from three patients. Follow-up radiographs were available for 10 cases. Joint space narrowing, or joint fusion, occurred in three cases. A broken screw each in one cat and one dog did not affect the stability of the joints involved. The technique described is simple and less invasive than partial arthrodesis and results suggest it as being a valuable alternative to partial arthrodesis. Early implant removal might possibly prevent cartilage damage and joint fusion due to prolonged immobilization.

scholarly journals Predictors of Radiographic Erosion and Joint Space Narrowing Progression in Patients with Early Rheumatoid Arthritis: A Cohort Study

2020 ◽  
Author(s):  
Emil Per Rydell ◽  
Kristina Forslind ◽  
Jan-Åke Nilsson ◽  
Magnus Karlsson ◽  
Kristina E Åkesson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Protein ◽  
Joint Space Narrowing ◽  
Cartilage Damage ◽  
Joint Space ◽  
Symptom Duration ◽  
Female Patients ◽  
Early Ra ◽  
Post Menopausal ◽  
Hands And Feet

Abstract Background Radiographic damage in rheumatoid arthritis (RA) includes erosions and joint space narrowing (JSN). Different mechanisms may underlie their development. The objective of this study was to evaluate predictors of these entities separately. Methods Consecutive early RA patients (symptom duration ≤12 months) from a defined area (Malmö, Sweden) recruited during 1995–2005 were investigated. Radiographs of hands and feet were scored by a trained reader according to the modified Sharp-van der Heijde score. Fat mass and lean mass distribution were measured at baseline using dual energy x-ray absorptiometry. Potential predictors of erosion- and JSN progression from inclusion to the 5-year follow-up were evaluated.Results Two hundred and thirty-three patients were included. Radiographs at baseline and 5 years were available for 162 patients. The median (interquartile) progression of erosion and JSN scores were 4 (0-8) and 8 (1-16), respectively. Rheumatoid factor (RF) was a robust significant predictor of both erosion- and JSN score progression. In adjusted analyses, anti-CCP antibodies predicted erosions while the erythrocyte sedimentation rate was predictive of both outcomes. Smoking, high levels of cartilage oligomeric matrix protein (>12 U/L) and high baseline disease activity (DAS28 >5.1) predicted progression of erosions. Baseline erosion score was associated with progression of both erosion- and JSN progression, while baseline JSN score was predictive only of the progression of JSN. Overweight/obesity (BMI ≥25kg/m2) was a significant negative predictor of JSN score progression (ß= -0.14, p= 0.018, adjusted for RF, age, baseline JSN score) also when additionally adjusting for ever smoking (p= 0.041). Among female patients, this effect was observed in those of estimated post-menopausal age (>51 years), but not in younger women. The truncal: peripheral fat ratio was associated with less JSN score progression in women, but not in men. Conclusions Overweight RA patients had less JSN progression, independent of smoking status. This effect was seen in particular among older women (mainly post-menopausal), but not younger. Truncal fat was associated with less JSN progression in female patients. Smoking predicted erosion progression, and erosions may precede JSN. BMI and fat distribution may influence cartilage damage in early RA and might be related to hormonal factors.

scholarly journals Predictors of radiographic erosion and joint space narrowing progression in patients with early rheumatoid arthritis: a cohort study

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Emil Rydell ◽  
Kristina Forslind ◽  
Jan-Åke Nilsson ◽  
Magnus Karlsson ◽  
Kristina E. Åkesson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Joint Space Narrowing ◽  
Smoking Status ◽  
Cartilage Damage ◽  
Joint Space ◽  
Symptom Duration ◽  
Female Patients ◽  
Early Ra ◽  
Post Menopausal ◽  
Hands And Feet

Abstract Background Radiographic damage in rheumatoid arthritis (RA) includes erosions and joint space narrowing (JSN). Different mechanisms may underlie their development. The objective of this study was to evaluate predictors of these entities separately. Methods Consecutive early RA patients (symptom duration ≤12 months) from a defined area (Malmö, Sweden) recruited during 1995–2005 were investigated. Radiographs of hands and feet were scored by a trained reader according to the modified Sharp-van der Heijde score. Fat mass and lean mass distribution were measured at baseline using dual energy x-ray absorptiometry. Potential predictors of erosion and JSN progression from inclusion to the 5-year follow-up were evaluated. Results Two hundred and thirty-three patients were included. Radiographs at baseline and 5 years were available for 162 patients. The median (interquartile) progression of erosion and JSN scores were 4 (0–8) and 8 (1–16), respectively. Rheumatoid factor (RF) was a robust significant predictor of both erosion and JSN score progression. In adjusted analyses, anti-CCP antibodies predicted erosions while the erythrocyte sedimentation rate was predictive of both outcomes. Smoking and high baseline disease activity (DAS28 > 5.1) predicted progression of erosions. Baseline erosion score was associated with progression of both erosion and JSN progression, while baseline JSN score was predictive only of the progression of JSN. Overweight/obesity (BMI ≥ 25 kg/m2) was a significant negative predictor of JSN score progression (β = − 0.14, p = 0.018, adjusted for RF, age, baseline JSN score) also when additionally adjusting for ever smoking (p = 0.041). Among female patients, this effect was observed in those of estimated post-menopausal age (> 51 years), but not in younger women. The truncal to peripheral fat ratio was associated with less JSN score progression in women, but not in men. Conclusions Overweight RA patients had less JSN progression, independent of smoking status. This effect was seen in particular among older women (mainly post-menopausal), but not younger. Truncal fat was associated with less JSN progression in female patients. Smoking predicted erosion progression, and erosions may precede JSN. BMI and fat distribution may influence cartilage damage in early RA and might be related to hormonal factors.

Association between radiographic joint space narrowing, function, pain and muscle power in severe osteoarthritis of the knee

2004 ◽  
Vol 18 (7) ◽  
pp. 793-800 ◽  
Author(s):  
Karen Barker ◽  
Sarah E Lamb ◽  
Francine Toye ◽  
Sarah Jackson ◽  
Sharon Barrington
Keyword(s):  
Joint Space Narrowing ◽  
Muscle Power ◽  
Joint Space ◽  
Osteoarthritis Of The Knee

scholarly journals Varus alignment of the proximal tibia is associated with structural progression in early to moderate varus osteoarthritis of the knee

2020 ◽  
Vol 28 (10) ◽  
pp. 3279-3286 ◽  
Author(s):  
Jonathan S. Palmer ◽  
Luke D. Jones ◽  
A. Paul Monk ◽  
Michael Nevitt ◽  
John Lynch ◽  
...  
Keyword(s):  
Cohort Study ◽  
Lower Limb ◽  
Joint Space Narrowing ◽  
Proximal Tibia ◽  
Joint Space ◽  
Medial Compartment ◽  
Osteoarthritis Of The Knee ◽  
Varus Alignment ◽  
Medial Proximal Tibial Angle ◽  
Structural Progression

Abstract Purpose Lower limb malalignment is a strong predictor of progression in knee osteoarthritis. The purpose of this study is to identify the individual alignment variables that predict progression in early to moderate osteoarthritis of the knee. Method A longitudinal cohort study using data from the Osteoarthritis Initiative. In total, 955 individuals (1329 knees) with early to moderate osteoarthritis (Kellgren-Lawrence grade 1, 2 or 3) were identified. All subjects had full-limb radiographs analysed using the Osteotomy module within Medicad® Classic (Hectec GMBH) to give a series of individual alignment variables relevant to the coronal alignment of the lower limb. Logistic regression models, with generalised estimating equations were used to identify which of these individual alignment variables predict symptom worsening (WOMAC score > 9 points) and or structural progression (joint space narrowing progression in the medial compartment > 0.7mm) over 24 months. Results Individual alignment variable were associated with both valgus and varus alignment (mechanical Lateral Distal Femoral Angle, Medial Proximal Tibial Angle and mechanical Lateral Distal Tibial Angle). Only the Medial Proximal Tibial Angle was significantly associated with structural progression and none of the variables was associated with symptom progression. The odds of joint space narrowing progression in the medial compartment occurring at 24 months increased by 21% for every one degree decrease (more varus) in Medial Proximal Tibial Angle (p < 0.001) Conclusions Our results suggest that the risk of structural progression in the medial compartment is associated with greater varus alignment of the proximal tibia. Level of evidence Level III, retrospective cohort study.

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