Paternal environmental exposures and gene expression during spermatogenesis: Research review to research framework

2008 ◽  
Vol 84 (2) ◽  
pp. 155-163 ◽  
Author(s):  
Deborah A. Hansen
Keyword(s):  
Gene Expression ◽  
Environmental Exposures ◽  
Research Review ◽  
Research Framework

An Integrated Research Framework for Effect of EWOM

2017 ◽  
Vol 5 (4) ◽  
pp. 343-355
Author(s):  
Jie Li ◽  
Wenyi Xue ◽  
Fang Yang ◽  
Yakun Li
Keyword(s):  
Electronic Commerce ◽  
Community Engagement ◽  
Word Of Mouth ◽  
Research Review ◽  
Related Factors ◽  
Research Framework ◽  
The Past ◽  
Reference Information ◽  
Integrated Research ◽  
The Relationship

AbstractWith the development of the electronic commerce, the electronic word-of-mouth (eWOM) has become important reference information for consumer shopping. EWOM has attracted considerable interest from researchers in the past decade. In this paper, a research review is conducted and an integrated framework is proposed on the effect of eWOM. The effect of eWOM are influenced by its characteristics, communicators, and other factors. The characteristics of eWOM include the source, the volume and the valence. The communicators of eWOM refer to the sender, the receiver and the relationship between them. In addition, dispersion and consistency, persistence and observability, anonymity and deception, and community engagement are related factors for the effect of eWOM.

scholarly journals Environmental epigenetics: a role in endocrine disease?

2012 ◽  
Vol 49 (2) ◽  
pp. R61-R67 ◽  
Author(s):  
Abby F Fleisch ◽  
Robert O Wright ◽  
Andrea A Baccarelli
Keyword(s):  
Gene Expression ◽  
Early Life ◽  
Endocrine Disrupting Chemicals ◽  
Environmental Exposures ◽  
Current Evidence ◽  
Epigenetic Mechanisms ◽  
Endocrine Effects ◽  
Endocrine Disease ◽  
Environmental Epigenetics ◽  
Endocrine Disrupting

Endocrine disrupting chemicals that are structurally similar to steroid or amine hormones have the potential to mimic endocrine endpoints at the receptor level. However, more recently, epigenetic-induced alteration in gene expression has emerged as an alternative way in which environmental compounds may exert endocrine effects. We review concepts related to environmental epigenetics and relevance for endocrinology through three broad examples: 1) effect of early-life nutritional exposures on future obesity and insulin resistance, 2) effect of lifetime environmental exposures such as ionizing radiation on endocrine cancer risk, and 3) potential for compounds previously classified as endocrine disrupting to additionally or alternatively exert effects through epigenetic mechanisms. The field of environmental epigenetics is still nascent, and additional studies are needed to confirm and reinforce data derived from animal models and preliminary human studies. Current evidence suggests that environmental exposures may significantly impact expression of endocrine-related genes and thereby affect clinical endocrine outcomes.

scholarly journals Transcriptional signatures throughout development: the effects of mouse embryo manipulation in vitro

Reproduction ◽  
2017 ◽  
Vol 153 (1) ◽  
pp. 107-122 ◽  
Author(s):  
Sky K Feuer ◽  
Xiaowei Liu ◽  
Annemarie Donjacour ◽  
Rhodel Simbulan ◽  
Emin Maltepe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Molecular Mechanisms ◽  
Preimplantation Embryo ◽  
Environmental Exposures ◽  
Developmental Time ◽  
Transcriptional Responses ◽  
Transcriptional Changes ◽  
Specific Impact

Stressful environmental exposures incurred early in development can affect postnatal metabolic health and susceptibility to non-communicable diseases in adulthood, although the molecular mechanisms by which this occurs have yet to be elucidated. Here, we use a mouse model to investigate how assortedin vitroexposures restricted exclusively to the preimplantation period affect transcription both acutely in embryos and long term in subsequent offspring adult tissues, to determine if reliable transcriptional markers ofin vitrostress are present at specific developmental time points and throughout development. Eachin vitrofertilization or embryo culture environment led to a specific and unique blastocyst transcriptional profile, but we identified a common 18-gene and 9-pathway signature of preimplantation embryo manipulation that was present in allin vitroembryos irrespective of culture condition or method of fertilization. This fingerprint did not persist throughout development, and there was no clear transcriptional cohesion between adult IVF offspring tissues or compared to their preceding embryos, indicating a tissue-specific impact ofin vitrostress on gene expression. However, the transcriptional changes present in each IVF tissue were targeted by the same upstream transcriptional regulators, which provide insight as to how acute transcriptional responses to stressful environmental exposures might be preserved throughout development to influence adult gene expression.

scholarly journals Mutational Signatures as Sensors of Environmental Exposures: Role of Smoking in COVID-19 Vulnerabilities

2021 ◽  
Author(s):  
Yoo-Ah Kim ◽  
Ermin Hodzic ◽  
Ariella Saslafsky ◽  
Damian Wojtowicz ◽  
Bayarbaatar Amgalan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Environmental Factors ◽  
Disease Progression ◽  
Environmental Exposures ◽  
Biological Processes ◽  
Mutational Signatures ◽  
Mutational Signature ◽  
The Impact ◽  
Pathway Level

Background: Environmental exposures such as smoking are widely recognized risk factors in the emergence of lung diseases such as lung cancer and acute respiratory distress syndrome (ARDS). However, the strength of environmental exposures is difficult to measure, making it challenging to understand their impacts. On the other hand, some COVID-19 patients develop ARDS in an unfavorable disease progression and smoking has been suggested as a potential risk factor among others. Yet initial studies on COVID-19 cases reported contradictory results on the effects of smoking on the disease. Some suggest that smoking might have a protective effect against it while other studies report an increased risk. A better understanding of how the exposure to smoking and other environmental factors affect biological processes relevant to SARS-CoV-2 infection and unfavorable disease progression is needed. Approach: In this study, we utilize mutational signatures associated with environmental factors as sensors of their exposure level. Many environmental factors including smoking are mutagenic and leave characteristic patterns of mutations, called mutational signatures, in affected genomes. We postulated that analyzing mutational signatures, combined with gene expression, can shed light on the impact of the mutagenic environmental factors to the biological processes. In particular, we utilized mutational signatures from lung adenocarcinoma (LUAD) data set collected in TCGA to investigate the role of environmental factors in COVID-19 vulnerabilities. Integrating mutational signatures with gene expression in normal tissues and using a pathway level analysis, we examined how the exposure to smoking and other mutagenic environmental factors affects the infectivity of the virus and disease progression. Results: By delineating changes associated with smoking in pathway-level gene expression and cell type proportions, our study demonstrates that mutational signatures can be utilized to study the impact of exogenous mutagenic factors on them. Consistent with previous findings, our analysis showed that smoking mutational signature (SBS4) is associated with activation of cytokines mediated singling pathways, leading to inflammatory responses. Smoking related changes in cell composition were also observed, including the correlation of SBS4 with the expansion of goblet cells. On the other hand, increased basal cells and decreased ciliated cells in proportion were associated with the strength of a different mutational signature (SBS5), which is present abundantly but not exclusively in smokers. In addition, we found that smoking increases the expression levels of genes that are upregulated in severe COVID-19 cases. Jointly, these results suggest an unfavorable impact of smoking on the disease progression and also provide novel findings on how smoking impacts biological processes in lung.

Annual Research Review: The contributions of the RDoC research framework on understanding the neurodevelopmental origins, progression and treatment of mental illnesses

2022 ◽  
Author(s):  
Jennifer Pacheco ◽  
Marjorie A. Garvey ◽  
Christopher S. Sarampote ◽  
Elan D. Cohen ◽  
Eric R. Murphy ◽  
...  
Keyword(s):  
Mental Illnesses ◽  
Research Review ◽  
Research Framework

Gene expression and metabolic responses of HepG2/C3A cells exposed to flame retardants and dust extracts at concentrations relevant to indoor environmental exposures

Chemosphere ◽  
2016 ◽  
Vol 144 ◽  
pp. 1996-2003 ◽  
Author(s):  
Jinkang Zhang ◽  
Mohamed Abou-Elwafa Abdallah ◽  
Timothy D. Williams ◽  
Stuart Harrad ◽  
James K. Chipman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Flame Retardants ◽  
Environmental Exposures ◽  
Metabolic Responses

Novel insights into the roles of RNA N-methyladenosine modification in regulating gene expression during environmental exposures

Chemosphere ◽  
2020 ◽  
Vol 261 ◽  
pp. 127757
Author(s):  
Dong Li ◽  
Xiaohua Zhu ◽  
Yunxiang Li ◽  
Xianyin Zeng
Keyword(s):  
Gene Expression ◽  
Environmental Exposures

scholarly journals The role of epigenetics in respiratory health in urban populations in low and middle-income countries

2019 ◽  
Vol 4 ◽  
Author(s):  
Nicole M. Robertson ◽  
Alex Kayongo ◽  
Trishul Siddharthan ◽  
Suzanne L. Pollard ◽  
Jose Gomez Villalobos ◽  
...  
Keyword(s):  
Gene Expression ◽  
Risk Factors ◽  
Respiratory Diseases ◽  
Respiratory Health ◽  
Environmental Exposures ◽  
Chronic Obstructive ◽  
Urban Populations ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low And Middle Income

Abstract As urbanization increases in low- and middle-income countries (LMICs), urban populations will be increasingly exposed to a range of environmental risk factors for non-communicable diseases. Inadequate living conditions in urban settings may influence mechanisms that regulate gene expression, leading to the development of non-communicable respiratory diseases. We conducted a systematic review of the literature to assess the relationship between respiratory health and epigenetic factors to urban environmental exposures observed in LMICs using MEDLINE, PubMed, EMBASE, and Google Scholar searching a combination of the terms: epigenetics, chronic respiratory diseases (CRDs), lung development, chronic obstructive airway disease, and asthma. A total of 2835 articles were obtained, and 48 articles were included in this review. We found that environmental factors during early development are related to epigenetic effects that may be associated with a higher risk of CRDs. Epigenetic dysregulation of gene expression of the histone deacetylase (HDAC) and histone acetyltransferase gene families was likely involved in lung health of slum dwellers. Respiratory-related environmental exposures influence HDAC function and deoxyribonucleic acid methylation and are important risk factors in the development of CRD. Additional epigenetic research is needed to improve our understanding of associations between environmental exposures and non-communicable respiratory diseases.

scholarly journals Environmental exposures and gene regulation in disease etiology

2008 ◽  
Vol 13 (1) ◽  
pp. 269-281 ◽  
Author(s):  
Thea M. Edwards ◽  
John Peterson Myers
Keyword(s):  
Gene Expression ◽  
Gene Regulation ◽  
Environmental Exposures ◽  
Regulatory Mechanisms ◽  
Industrial Chemicals ◽  
Disease Etiology ◽  
Environmental Health Research ◽  
Genes And Environment ◽  
Broad Array ◽  
Gene Regulatory

Health or disease is shaped for all individuals by interactions between their genes and environment. Exactly how the environment changes gene expression and how this can lead to disease are being explored in a fruitful new approach to environmental health research, representative studies of which are reviewed here. We searched Web of Science and references of relevant publications to understand the diversity of gene regulatory mechanisms affected by environmental exposures with disease implications. Pharmaceuticals, pesticides, air pollutants, industrial chemicals, heavy metals, hormones, nutrition, and behavior can change gene expression through a broad array of gene regulatory mechanisms. Furthermore, chemically induced changes in gene regulation are associated with serious and complex human diseases, including cancer, diabetes and obesity, infertility, respiratory diseases, allergies, and neurodegenerative disorders such as Parkinson and Alzheimer diseases. The reviewed studies indicate that genetic predisposition for disease is best predicted in the context of environmental exposures. And the genetic mechanisms investigated in these studies offer new avenues for risk assessment research. Finally, we are likely to witness dramatic improvements in human health, and reductions in medical costs, if environmental pollution is decreased.

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