Heterologous production of polyunsaturated fatty acids in Saccharomyces cerevisiae causes a global transcriptional response resulting in reduced proteasomal activity and increased oxidative stress

2010 ◽  
Vol 6 (3) ◽  
pp. 343-356 ◽  
Author(s):  
Rawisara Ruenwai ◽  
Andrea Neiss ◽  
Kobkul Laoteng ◽  
Wanwipa Vongsangnak ◽  
Arastoo Badoei Dalfard ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Saccharomyces Cerevisiae ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Transcriptional Response ◽  
Heterologous Production ◽  
Proteasomal Activity

N-3 polyunsaturated fatty acids prevents sterile pericarditis-induced atrial fibrillation by inhibiting oxidative stress in canine

2014 ◽  
Vol 35 (10) ◽  
pp. 1066
Author(s):  
Zhong ZHANG ◽  
Shou-qin SHAN ◽  
Qiang-sun ZHENG ◽  
Jin-bo ZHAO ◽  
Chun-cao YAN ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atrial Fibrillation ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids

Adaptation to oxidative stress induced by polyunsaturated fatty acids in yeast

2008 ◽  
Vol 1781 (6-7) ◽  
pp. 283-287 ◽  
Author(s):  
Ana Cipak ◽  
Morana Jaganjac ◽  
Oksana Tehlivets ◽  
Sepp D. Kohlwein ◽  
Neven Zarkovic
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids

Improvement of polyunsaturated fatty acids synthesis by the coexpression of CYB5 with desaturase genes in Saccharomyces cerevisiae

2010 ◽  
Vol 87 (6) ◽  
pp. 2185-2193 ◽  
Author(s):  
Hisashi Yazawa ◽  
Hitoshi Iwahashi ◽  
Yasushi Kamisaka ◽  
Kazuyoshi Kimura ◽  
Hiroshi Uemura
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids

scholarly journals Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress

Nutrients ◽  
2017 ◽  
Vol 9 (8) ◽  
pp. 895 ◽  
Author(s):  
Michela Zanetti ◽  
Gianluca Gortan Cappellari ◽  
Davide Barbetta ◽  
Annamaria Semolic ◽  
Rocco Barazzoni
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Endothelial Dysfunction ◽  
Polyunsaturated Fatty Acids ◽  
Omega 3

Total Synthesis of DHA and DPAn-3 non-enzymatic oxylipins

Synthesis ◽  
2021 ◽  
Author(s):  
alexandre guy ◽  
Jérémy Merad ◽  
Thomas Degrange ◽  
Guillaume Reversat ◽  
Valérie Bultel-Poncé ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Total Synthesis ◽  
Biological Properties ◽  
Chemical Structures ◽  
Structural Variety ◽  
Synthetic Strategy

Oxylipins are formed in-vivo from polyunsaturated fatty acids (PUFAs). A large structural variety of compounds is grouped under the term oxylipins, which differ from their formation mechanism (involving enzymes or not), as well as their chemical structures (cyclopentanes, tetrahydrofurans, hydroxylated-PUFA etc.). All structures of oxylipins are of great biological interests. Directly correlated to oxidative stress phenomenon, non-enzymatic oxylipins are used as systemic and/or specific biomarkers in various pathologies and more especially, they were found to have their own biological properties. Produced in-vivo as a non-separable mixture of isomers, total synthesis is a keystone to answer biological questions. In this work, we described the total synthesis of three non-enzymatic oxylipins derived from docosahexaenoic acid (DHA) and docosapentanoic acid (DPAn-3) using a unique and convergent synthetic strategy.

scholarly journals Deuterated Polyunsaturated Fatty Acids Reduce Oxidative Stress and Extend the Lifespan of C. elegans

2019 ◽  
Vol 10 ◽  
Author(s):  
Caroline Beaudoin-Chabot ◽  
Lei Wang ◽  
Alexey V. Smarun ◽  
Dragoslav Vidović ◽  
Mikhail S. Shchepinov ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
C Elegans
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