One‐Pot Synthesis of Highly Monodisperse Poly(lactic‐co‐glycolic Acid) Particles with Controlled Porosity as Efficient Drug Delivery Vehicles

2019 ◽  
Vol 40 (9) ◽  
pp. 851-856 ◽  
Author(s):  
Yoon Hyuck Kim ◽  
Junhyoung Byun ◽  
Byoungjae Kim ◽  
Kijeong Lee ◽  
Jae‐Seung Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glycolic Acid ◽  
One Pot ◽  
Drug Delivery Vehicles ◽  
One Pot Synthesis ◽  
Controlled Porosity ◽  
Delivery Vehicles

Facile one-pot synthesis of carbon/calcium phosphate/Fe3O4 composite nanoparticles for simultaneous imaging and pH/NIR-responsive drug delivery

2016 ◽  
Vol 52 (74) ◽  
pp. 11068-11071 ◽  
Author(s):  
Mingyu Gou ◽  
Shengnan Li ◽  
Lingyu Zhang ◽  
Lu Li ◽  
Chungang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Photothermal Therapy ◽  
Composite Nanoparticles ◽  
One Pot ◽  
Drug Delivery Vehicles ◽  
Simultaneous Imaging ◽  
One Pot Synthesis ◽  
Delivery Vehicles

We report herein a facile one-pot synthesis of carbon/calcium phosphate/Fe3O4 composite nanoparticles, which were employed as pH/NIR-responsive drug delivery vehicles for simultaneous MRI and chemo-photothermal therapy.

Development of enhanced drug delivery vehicles for three cannabis-based terpenes using poly(lactic-co-glycolic acid) based nanoparticles

2021 ◽  
Vol 164 ◽  
pp. 113345
Author(s):  
Mazen M. El-Hammadi ◽  
Andrea L. Small-Howard ◽  
Mercedes Fernández-Arévalo ◽  
Lucía Martín-Banderas
Keyword(s):  
Drug Delivery ◽  
Glycolic Acid ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine

2018 ◽  
Vol 18 (5) ◽  
pp. 439-457 ◽  
Author(s):  
Merina Mariyam ◽  
Kajal Ghosal ◽  
Sabu Thomas ◽  
Nandakumar Kalarikkal ◽  
Mahima S. Latha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
General Aspects

Novel Phospholipid-Based Labrasol Nanomicelles Loaded Flavonoids for Oral Delivery with Enhanced Penetration and Anti-Brain Tumor Efficiency

2020 ◽  
Vol 17 (3) ◽  
pp. 229-245
Author(s):  
Gang Wang ◽  
Junjie Wang ◽  
Rui Guan
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Oral Delivery ◽  
Safe Delivery ◽  
Drug Delivery Vehicles ◽  
Therapeutic Benefits ◽  
Delivery Vehicles ◽  
The Brain

Background: Owing to the rich anticancer properties of flavonoids, there is a need for their incorporation into drug delivery vehicles like nanomicelles for safe delivery of the drug into the brain tumor microenvironment. Objective: This study, therefore, aimed to prepare the phospholipid-based Labrasol/Pluronic F68 modified nano micelles loaded with flavonoids (Nano-flavonoids) for the delivery of the drug to the target brain tumor. Methods: Myricetin, quercetin and fisetin were selected as the initial drugs to evaluate the biodistribution and acute toxicity of the drug delivery vehicles in rats with implanted C6 glioma tumors after oral administration, while the uptake, retention, release in human intestinal Caco-2 cells and the effect on the brain endothelial barrier were investigated in Human Brain Microvascular Endothelial Cells (HBMECs). Results: The results demonstrated that nano-flavonoids loaded with myricetin showed more evenly distributed targeting tissues and enhanced anti-tumor efficiency in vivo without significant cytotoxicity to Caco-2 cells and alteration in the Trans Epithelial Electric Resistance (TEER). There was no pathological evidence of renal, hepatic or other organs dysfunction after the administration of nanoflavonoids, which showed no significant influence on cytotoxicity to Caco-2 cells. Conclusion: In conclusion, Labrasol/F68-NMs loaded with MYR and quercetin could enhance antiglioma effect in vitro and in vivo, which may be better tools for medical therapy, while the pharmacokinetics and pharmacodynamics of nano-flavonoids may ensure optimal therapeutic benefits.

scholarly journals Functionalization of Reduced Graphene Oxide via Thiol–Maleimide “Click” Chemistry: Facile Fabrication of Targeted Drug Delivery Vehicles

2017 ◽  
Vol 9 (39) ◽  
pp. 34194-34203 ◽  
Author(s):  
Yavuz Oz ◽  
Alexandre Barras ◽  
Rana Sanyal ◽  
Rabah Boukherroub ◽  
Sabine Szunerits ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Click Chemistry ◽  
Reduced Graphene Oxide ◽  
Targeted Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Reduced Graphene ◽  
Facile Fabrication ◽  
Delivery Vehicles ◽  
Targeted Drug

scholarly journals Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 427
Author(s):  
Amin Mirzaaghasi ◽  
Yunho Han ◽  
So-Hee Ahn ◽  
Chulhee Choi ◽  
Ji-Ho Park
Keyword(s):  
Drug Delivery ◽  
Therapeutic Potential ◽  
Hek293t Cell ◽  
Biological Properties ◽  
Context Analysis ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Diseased State ◽  
Sepsis And Septic Shock

Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize their therapeutic potential as drug delivery vehicles. In this study, we investigated biodistribution and pharmacokinetics of HEK293T cell-derived exosomes and PEGylated liposomes, their synthetic counterparts, into healthy and sepsis mice. We found that biodistribution and pharmacokinetics of exosomes were significantly affected by pathophysiological conditions of sepsis compared to those of liposomes. In the sepsis mice, a substantial number of exosomes were found in the lung after intravenous injection, and their prolonged blood residence was observed due to the liver dysfunction. However, liposomes did not show such sepsis-specific effects significantly. These results demonstrate that exosome-based therapeutics can be developed to manage sepsis and septic shock by virtue of their sepsis-specific in vivo behaviors.

Facile One‐Pot Synthesis of Magnetic Targeted Polymers for Drug Delivery and Study on Thermal Decomposition Kinetics

2021 ◽  
Vol 6 (6) ◽  
pp. 1191-1198
Author(s):  
Zhen Shi ◽  
Yazhen Wang ◽  
Yu Sun ◽  
Xueying Wu ◽  
Tianyuan Xiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Thermal Decomposition ◽  
Decomposition Kinetics ◽  
Thermal Decomposition Kinetics ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3589
Author(s):  
Rui Liu ◽  
Alessandro Poma
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymers ◽  
Drug Loading ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Drug Delivery Vehicles ◽  
The Past ◽  
Drug Molecules ◽  
Delivery Vehicles

Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years.

scholarly journals A Review on Allopathic and Herbal Nanofibrous Drug Delivery Vehicles for Cancer Treatments

2021 ◽  
pp. e00663
Author(s):  
Tarun Mateti ◽  
Surabhi Aswath ◽  
Anoop Kishore Vatti ◽  
Agneya Kamath ◽  
Anindita Laha
Keyword(s):  
Drug Delivery ◽  
Cancer Treatments ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Exploring the utility of hybrid siloxane-phosphocholine (SiPC) liposomes as drug delivery vehicles

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 13014-13023
Author(s):  
Mark B. Frampton ◽  
Andrea Blais ◽  
Zachary Raczywolski ◽  
Alan Castle ◽  
Paul M. Zelisko
Keyword(s):  
Drug Delivery ◽  
Aqueous Media ◽  
Unilamellar Vesicles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Hybrid siloxane-phosphocholines (SiPCs) are a unique class of lipids that spontaneously form unilamellar vesicles (ULVs) that are ∼100 nm in diameter upon exposure to aqueous media without the need for extrusion and can be used as delivery vehicles.

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