UHPLC‐Q‐TOF‐MS/MS based metabolite profiling of duvelisib and establishment of its metabolism mechanisms

2022 ◽  
Author(s):  
Dipali Sonawane ◽  
Amit Kumar Sahu ◽  
Tarang Jadav ◽  
Pinaki Sengupta
Keyword(s):  
Metabolite Profiling ◽  
Tof Ms

Metabolite profiling of steroidal glycosides in the rhizome of Aspidistra sichuanensis using UPLC/Q-TOF MS E

2017 ◽  
Vol 415 ◽  
pp. 63-84 ◽  
Author(s):  
Jie Peng ◽  
Yang Zhao ◽  
Lu Xu ◽  
Li-ping Kang ◽  
Jiang-ming Cui ◽  
...  
Keyword(s):  
Metabolite Profiling ◽  
Steroidal Glycosides ◽  
Tof Ms

scholarly journals Analysis of Metabolite Profiling in Human Endothelial Cells after Plasma Jet Treatment

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Yanjie Yang ◽  
Dehui Xu ◽  
Ning Ning ◽  
Yujing Xu
Keyword(s):  
Endothelial Cells ◽  
Plasma Treatment ◽  
Metabolite Profiling ◽  
Atmospheric Plasma ◽  
Human Endothelial Cells ◽  
Metabolic Pathway Analysis ◽  
Orthogonal Projections ◽  
Blood Capillaries ◽  
Latent Structures ◽  
Tof Ms

Cold atmospheric plasma (CAP) is a novel technology, which has been widely applied in biomedicine, especially in wound healing, dermatological treatment, hemostasis, and cancer treatment. In most cases, CAP treatment will interact with innumerable blood capillaries. Therefore, it is important and necessary to understand the effects of CAP treatment on endothelial cell metabolism. In this study, the metabolite profiling of plasma treatment on endothelial cells was measured by gas chromatography tandem time-of-flight mass spectrometry (GC-TOF-MS). We found that 695 signals (metabolites) were detected by GC-TOF-MS and then evaluated using orthogonal projections to latent structures discriminant analysis (OPLS-DA). All the differential metabolites were listed, and proline and xanthosine were the two of the most downregulated metabolites by plasma treatment. By comprehensive metabolic pathway analysis with the KEGG pathway, we showed that alanine, aspartate, glutamate, and purine metabolism pathways were the most significantly suppressed after gas plasma treatment in human endothelial cells. Our finding gives an overall picture of the metabolic pathways affected by plasma treatment in endothelial cells.

UPLC-ESI-TOF MS-Based Metabolite Profiling of the Antioxidative Food Supplement Garcinia buchananii

2015 ◽  
Vol 63 (32) ◽  
pp. 7169-7179 ◽  
Author(s):  
Timo D. Stark ◽  
Sofie Lösch ◽  
Junichiro Wakamatsu ◽  
Onesmo B. Balemba ◽  
Oliver Frank ◽  
...  
Keyword(s):  
Metabolite Profiling ◽  
Food Supplement ◽  
Garcinia Buchananii ◽  
Tof Ms

scholarly journals Metabolite profiling of RCS-4, a novel synthetic cannabinoid designer drug, using human hepatocyte metabolism and TOF-MS

Bioanalysis ◽  
2014 ◽  
Vol 6 (11) ◽  
pp. 1471-1485 ◽  
Author(s):  
Adarsh S Gandhi ◽  
Mingshe Zhu ◽  
Shaokun Pang ◽  
Ariane Wohlfarth ◽  
Karl B Scheidweiler ◽  
...  
Keyword(s):  
Metabolite Profiling ◽  
Human Hepatocyte ◽  
Synthetic Cannabinoid ◽  
Designer Drug ◽  
Hepatocyte Metabolism ◽  
Tof Ms

Metabolite profiling of Zi-Shen pill in rat biological specimens by UPLC-Q-TOF/MS

2015 ◽  
Vol 13 (2) ◽  
pp. 145-160 ◽  
Author(s):  
Xiao-Wei LIU ◽  
Feng ZHANG ◽  
Shou-Hong GAO ◽  
Bo JIANG ◽  
Wan-Sheng CHEN
Keyword(s):  
Metabolite Profiling ◽  
Tof Ms

scholarly journals Optimization of Metabolite Extraction Protocols for Untargeted Metabolite Profiling of Mycoparasitic Scytalidium parasiticum using LC-TOF-MS

2018 ◽  
Vol 47 (12) ◽  
pp. 3061-3068 ◽  
Author(s):  
Choon Kiat Lim ◽  
Rafidah Ahmad ◽  
Nurul Fadhilah Marzuki ◽  
Yit Kheng Goh ◽  
Kamalrul Azlan Azizan ◽  
...  
Keyword(s):  
Metabolite Profiling ◽  
Untargeted Metabolite Profiling ◽  
Metabolite Extraction ◽  
Tof Ms

scholarly journals A UPLC-Q-TOF/MS-Based Metabolomics Study on the Effect of Corallodiscus flabellatus (Craib) B. L. Burtt Extract on Alzheimer’s Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yang-Yang Wang ◽  
Ning Zhou ◽  
Yan-Po Si ◽  
Zhi-Yao Bai ◽  
Meng Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metabolite Profiling ◽  
Huperzine A ◽  
Control Group ◽  
Model Group ◽  
Metabolomics Study ◽  
Samp8 Mice ◽  
Senescence Accelerated Mouse ◽  
Tof Ms

A UPLC-Q-TOF/MS-based metabolomics study was carried out to explore the intervening mechanism of Corallodiscus flabellatus (Craib) B. L. Burtt (CF) extract on Alzheimer’s disease (AD). The AD model group consisted of senescence-accelerated mouse prone 8 (SAMP8) mice, and the control group consisted of senescence-accelerated mouse resistant 1 (SAMR1) mice. UPLC-Q-TOF/MS detection, multivariate statistical analysis, and pathway enrichment were jointly performed to research the change in metabolite profiling in the urine of AD mice. The result suggested that the metabolite profiling of SAMP8 mice significantly changed at the sixth month compared with SAMR1 mice of the same age, and the principal component analysis (PCA) score scatter plots of the CF group closely resembled those of the control and positive drug (huperzine A, HA) group. A total of 28 metabolites were considered potential biomarkers associated with the metabolism of beta-alanine, glycine, serine, threonine, cysteine, methionine, arginine, proline, and purines in AD mice. Furthermore, the CF group was clustered with the control and positive group and was clearly separated from the model group in the heat map. In conclusion, significant anti-AD effects were firstly observed in mice after treatment with the CF extract, and the urinary metabolomics approach assisted with dissecting the underlying mechanism.

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