Decrease of adenosine deaminase activity and increase of the lipid peroxidation after acute methotrexate treatment in young rats: protective effects of grape seed extract

2010 ◽  
Vol 28 (1) ◽  
pp. 89-94 ◽  
Author(s):  
F. V. Pinheiro ◽  
V. C. Pimentel ◽  
K. S. De Bona ◽  
G. Scola ◽  
M. Salvador ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Adenosine Deaminase ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Protective Effects ◽  
Young Rats ◽  
Adenosine Deaminase Activity ◽  
Methotrexate Treatment

scholarly journals Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Vivian Molina Cuevas ◽  
Yazmín Ravelo Calzado ◽  
Yohani Pérez Guerra ◽  
Ambar Oyarzábal Yera ◽  
Sonia Jiménez Despaigne ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Gastric Ulcer ◽  
Vitamin E ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Positive Control ◽  
Negative Control ◽  
Seed Extract ◽  
Gastric Ulcers ◽  
Control Group

Effects of GSE and vitamins C and E on aspirin- and ethanol-induced gastric ulcer and associated increases of lipid peroxidation in rats were compared. Two experiments were conducted. Rats were randomized into eight groups: a negative control and seven groups that received aspirin or ethanol for ulcer induction: one positive control (vehicle) and six with VC, VE, or GSE (25 and 250 mg/kg). Ulcer indexes and gastric levels of malondialdehyde (MDA) were quantified. VC, VE, and GSE (25 and 250 mg/kg) decreased aspirin, and ethanol-induced ulcers and MDA values compared with positive control group. The magnitude of aspirin ulcer reduction was comparable for all treatments, and MDA decrease with GSE was higher than with VC and tended to be greater, albeit none significantly, than with VE. GSE was more effective than VC and VE for lowering the ethanol ulcers, while the decrease of MDA levels with GSE was greater than with VC, but comparable to that achieved with VE. GSE protected against ethanol-induced gastric ulcers more effectively than VC or VE, while its protection against aspirin ulcers was comparable for all treatments. GSE produced the greatest reductions of gastric MDA in both models.

scholarly journals Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Heba M. Abdou ◽  
Mayssaa M. Wahby
Keyword(s):  
Vitamin B6 ◽  
Hematological Parameters ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Cerebral Injury ◽  
Pcr Analysis ◽  
Albino Rats ◽  
Inos Mrna ◽  
Protective Effects

Triton WR-1339 administration causes neurotoxicity. Natural products and herbal extracts can attenuate cerebral injury. In the present study, we investigated the neuroprotective role of grape seed extract and/or vitamin B6 against triton-induced neurotoxicity. Thirty-five adult male albino rats of the Sprague-Dawley strain, weighing 140–145 g, were divided into five groups: control, triton, grape seed extract + triton, grape seed extract + triton + vitamin B6, and vitamin B6 + triton. The hematological and biochemical analyses were carried out. Alteration in iNOS mRNA gene expression was determined using reverse-transcriptase PCR analysis. In addition, qualitative DNA fragmentation was examined using agarose gel electrophoresis. Triton-treatment caused significant disturbances in the hematological parameters, the neurological functions, and the antioxidant profile. Also, triton significantly increased the iNOS mRNA expression and DNA damage. Our results showed that grape seed extract and/or vitamin B6 could attenuate all the examined parameters. These natural substances could exhibit protective effects against triton-induced neurological damage because of their antioxidative and antiapoptotic capacities.

Protective effects of polydatin and grape seed extract in rats exposed to cadmium

2018 ◽  
Vol 43 (3) ◽  
pp. 225-233 ◽  
Author(s):  
Mustafa Evcimen ◽  
Recep Aslan ◽  
Mehmet Sukru Gulay
Keyword(s):  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Protective Effects

scholarly journals Antioxidant/Prooxidant and Antibacterial/Probacterial Effects of a Grape Seed Extract in Complex with Lipoxygenase

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Veronica Sanda Chedea ◽  
Cornelia Braicu ◽  
Flore Chirilă ◽  
Henry Joseph Oduor Ogola ◽  
Rodica Ştefania Pelmuş ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Control Level ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Grape Seeds ◽  
E Coli ◽  
Prooxidant Action ◽  
High Level ◽  
Short Time

In an attempt to determine the antioxidant/prooxidant, antibacterial/probacterial action of flavan-3-ols and procyanidins from grape seeds, pure catechin (CS), and an aqueous grape seed extract (PE), were applied in the absence and presence of pure lipoxygenase (LS) or in extract (LE) to leucocyte culture,Escherichia coli B41andBrevibacterium linens, and observed whether there was any effect on lipid peroxidation, cytotoxicity, or growth rate. Short time periods of coincubation of cells with the polyphenols, followed by the exposure to LS and LE, revealed a high level of lipid peroxidation and a prooxidative effect. Longer coincubation and addition of LS and LE resulted in the reversal of the prooxidant action either to antioxidant activity for CS + LS and PE + LS or to the control level for CS + LE and PE + LE. Lipid peroxidation was significantly reduced when cells were exposed to polyphenols over a longer period. Longer exposure ofE. colito CS or PE followed by addition of LS for 3 h resulted in bactericidal activity. Significant stimulatory effect on microbial growth was observed for PE + LS and PE + LE treatments inB. linens, illustrating the potential probacterial activity inB. linenscultures. Lipoxygenase-polyphenols complex formation was found to be responsible for the observed effects.

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