Metformin suppresses self‐renewal and stemness of cancer stem cell models derived from pluripotent stem cells

2021 ◽  
Author(s):  
Maram H. Zahra ◽  
Said M. Afify ◽  
Ghmkin Hassan ◽  
Hend M. Nawara ◽  
Kazuki Kumon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Pluripotent Stem Cells ◽  
Cell Models ◽  
Self Renewal ◽  
Stem Cell Models

scholarly journals Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 104763-104781 ◽  
Author(s):  
Aleksandra Božić ◽  
Aleksandar Marinković ◽  
Snežana Bjelogrlić ◽  
Tamara R. Todorović ◽  
Ilija N. Cvijetić ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Antitumor Activity ◽  
Cancer Stem Cell ◽  
Cell Models ◽  
Target Profile ◽  
Apoptotic Activity ◽  
2D And 3D ◽  
Stem Cell Models

Study of antitumor activity of mono- and bis-quinoline based (thio)carbohydrazones on THP-1 and AsPC-1 cancer stem cells, revealed that thiocarbohydrazones had superior pro-apoptotic activity than carbohydrazones with multi-target profile activities.

scholarly journals Reconstructing aspects of human embryogenesis with pluripotent stem cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Berna Sozen ◽  
Victoria Jorgensen ◽  
Bailey A. T. Weatherbee ◽  
Sisi Chen ◽  
Meng Zhu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Pluripotent Stem Cells ◽  
Clinical Importance ◽  
Early Embryo ◽  
Transcriptional Level ◽  
Cell Models ◽  
Human Embryogenesis ◽  
Cavitation Characteristic ◽  
Stem Cell Models

AbstractUnderstanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown. Here, we attempt to model human early embryo development with expanded pluripotent stem cells (EPSCs) in 3-dimensions. We define a protocol that allows us to generate self-organizing cystic structures from human EPSCs that display some hallmarks of human early embryogenesis. These structures mimic polarization and cavitation characteristic of pre-implantation development leading to blastocyst morphology formation and the transition to post-implantation-like organization upon extended culture. Single-cell RNA sequencing of these structures reveals subsets of cells bearing some resemblance to epiblast, hypoblast and trophectoderm lineages. Nevertheless, significant divergences from natural blastocysts persist in some key markers, and signalling pathways point towards ways in which morphology and transcriptional-level cell identities may diverge in stem cell models of the embryo. Thus, this stem cell platform provides insights into the design of stem cell models of embryogenesis.

Integrin α6 (CD49f), The Microenvironment and Cancer Stem Cells

2019 ◽  
Vol 14 (5) ◽  
pp. 428-436 ◽  
Author(s):  
Gabriele D. Bigoni-Ordóñez ◽  
Daniel Czarnowski ◽  
Tyler Parsons ◽  
Gerard J. Madlambayan ◽  
Luis G. Villa-Diaz
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
The Self ◽  
Self Renewal ◽  
Terminal Disease

Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known as CD49f) in cancer stem cell (CSC) activity. ITGA6 is commonly used to identify CSC populations in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnecting them with the tumorigenic microenvironment.

Reprogramming Prostate Cancer Cells into Induced Pluripotent Stem Cells: a Promising Model of Prostate Cancer Stem Cell Research

2020 ◽  
Vol 22 (5) ◽  
pp. 262-268 ◽  
Author(s):  
Yiming Zhang ◽  
Binshen Chen ◽  
Peng Xu ◽  
Chunxiao Liu ◽  
Peng Huang
Keyword(s):  
Prostate Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Induced Pluripotent Stem Cells ◽  
Cancer Cells ◽  
Stem Cell Research ◽  
Pluripotent Stem Cells ◽  
Prostate Cancer Cells ◽  
Induced Pluripotent

Insight into Cancer Stem Cell Niche; Lessons from Cancer Stem Cell Models Generated In Vitro

2015 ◽  
pp. 211-226
Author(s):  
Akifumi Mizutani ◽  
Ting Yan ◽  
Arun Vaidyanath ◽  
Junko Masuda ◽  
Akimasa Seno ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Stem Cell Niche ◽  
Cell Models ◽  
Cell Niche ◽  
Stem Cell Models ◽  
Insight Into

scholarly journals Regeneration of cervical reserve cell-like cells from human induced pluripotent stem cells (iPSCs): A new approach to finding targets for cervical cancer stem cell treatment

Oncotarget ◽  
2017 ◽  
Vol 8 (25) ◽  
pp. 40935-40945 ◽  
Author(s):  
Masakazu Sato ◽  
Kei Kawana ◽  
Katsuyuki Adachi ◽  
Asaha Fujimoto ◽  
Mitsuyo Yoshida ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
New Approach ◽  
Induced Pluripotent ◽  
Stem Cell Treatment ◽  
Reserve Cell

scholarly journals Abnormal Glycosylation of Cancer Stem Cells and Targeting Strategies

2021 ◽  
Vol 11 ◽  
Author(s):  
Thahomina Khan ◽  
Horacio Cabral
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Signaling Pathways ◽  
Intracellular Signaling ◽  
Self Renewal ◽  
Tumor Relapse ◽  
Intracellular Signaling Pathways ◽  
Abnormal Glycosylation

Cancer stem cell (CSCs) are deemed as one of the main reasons of tumor relapse due to their resistance to standard therapies. Numerous intracellular signaling pathways along with extracellular features are crucial in regulating CSCs properties, such as heterogeneity, plasticity and differentiation. Aberrant glycosylation of these cellular signaling pathways and markers of CSCs have been directly correlated with maintaining survival, self-renewal and extravasation properties. In this review, we highlight the importance of glycosylation in promoting stemness character of CSCs, and present strategies for targeting abnormal glycosylation to eliminate the resistant CSC population.

scholarly journals Abstract 926: Generation of a potential breast cancer stem cell model from induced pluripotent stem cells

2017 ◽  
Author(s):  
Neha Nair ◽  
Anna Sanchez Calle ◽  
Maram Hussein Zahra ◽  
Aung Ko Ko Oo ◽  
Arun Vaidyanath ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Cell Model ◽  
Stem Cell Model ◽  
Induced Pluripotent ◽  
Cancer Stem Cell Model

scholarly journals Activation of glycogenolysis and glycolysis in breast cancer stem cell models

2020 ◽  
Vol 1866 (10) ◽  
pp. 165886 ◽  
Author(s):  
Etna Abad ◽  
Sara Samino ◽  
Oscar Yanes ◽  
David Potesil ◽  
Zbynek Zdrahal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Breast Cancer Stem Cell ◽  
Cell Models ◽  
Stem Cell Models
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