Role of mitochondrial dysfunction in the pathophysiology of DNA repair disorders

2018 ◽  
Vol 42 (6) ◽  
pp. 643-650 ◽  
Author(s):  
Mateus Prates Mori ◽  
Nadja Cristhina de Souza-Pinto
Keyword(s):  
Dna Repair ◽  
Mitochondrial Dysfunction

scholarly journals Alteration of Mitochondrial Function and Insulin Sensitivity in Primary Mouse Skeletal Muscle Cells Isolated From Transgenic and Knockout Mice: Role of OGG1

Endocrinology ◽  
2013 ◽  
Vol 154 (8) ◽  
pp. 2640-2649 ◽  
Author(s):  
Larysa V. Yuzefovych ◽  
A. Michele Schuler ◽  
Jemimah Chen ◽  
Diego F. Alvarez ◽  
Lars Eide ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Dna Repair ◽  
Insulin Sensitivity ◽  
Transgenic Mice ◽  
Mitochondrial Dysfunction ◽  
Knockout Mice ◽  
Repair Enzyme ◽  
Mitochondrial Mass ◽  
Mtdna Damage

Abstract Recent evidence has linked mitochondrial dysfunction and DNA damage, increased oxidative stress in skeletal muscle, and insulin resistance (IR). The purpose of this study was to determine the role of the DNA repair enzyme, human 8-oxoguanine DNA glycosylase/apurinic/apyrimidinic lyase (hOGG1), on palmitate-induced mitochondrial dysfunction and IR in primary cultures of skeletal muscle derived from hind limb of ogg1−/− knockout mice and transgenic mice, which overexpress human (hOGG1) in mitochondria (transgenic [Tg]/MTS-hOGG1). Following exposure to palmitate, we evaluated mitochondrial DNA (mtDNA) damage, mitochondrial function, production of mitochondrial reactive oxygen species (mtROS), mitochondrial mass, JNK activation, insulin signaling pathways, and glucose uptake. Palmitate-induced mtDNA damage, mtROS, mitochondrial dysfunction, and activation of JNK were all diminished, whereas ATP levels, mitochondrial mass, insulin-stimulated phosphorylation of Akt (Ser 473), and insulin sensitivity were increased in primary myotubes isolated from Tg/MTS-hOGG1 mice compared to myotubes isolated from either knockout or wild-type mice. In addition, both basal and maximal respiratory rates during mitochondrial oxidation on pyruvate showed a variable response, with some animals displaying an increased respiration in muscle fibers isolated from the transgenic mice. Our results support the model that DNA repair enzyme OGG1 plays a pivotal role in repairing mtDNA damage, and consequently, in mtROS production and regulating downstream events leading to IR in skeletal muscle.

Role of Oxidative Stress and Mitochondrial Dysfunction in Skeletal Muscle in Type 2 Diabetic Patients

2016 ◽  
Vol 22 (18) ◽  
pp. 2650-2656 ◽  
Author(s):  
Noelia Diaz-Morales ◽  
Susana Rovira-Llopis ◽  
Irene Escribano-Lopez ◽  
Celia Bañuls ◽  
Sandra Lopez-Domenech ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Mitochondrial Dysfunction ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Role of Mis Localization of DNA Repair Factors in Cell Cycle Arrest

2019 ◽  
Vol 116 (3) ◽  
pp. 76a
Author(s):  
Manasvita Vashisth ◽  
Sangkyun Cho ◽  
Dennis Discher
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Cell Cycle Arrest ◽  
Cycle Arrest

Sepsis-induced myocardial dysfunction: the role of mitochondrial dysfunction

2021 ◽  
Vol 70 (4) ◽  
pp. 379-387
Author(s):  
Hang Yang ◽  
Zhaocai Zhang
Keyword(s):  
Mitochondrial Dysfunction ◽  
Myocardial Dysfunction

scholarly journals Copy number analyses of DNA repair genes reveal the role of poly(ADP-ribose) polymerase (PARP) in tree longevity

iScience ◽  
2021 ◽  
pp. 102779
Author(s):  
Yuta Aoyagi Blue ◽  
Junko Kusumi ◽  
Akiko Satake
Keyword(s):  
Dna Repair ◽  
Copy Number ◽  
Dna Repair Genes ◽  
Repair Genes

Relevance of mitochondrial dysfunction during Sorafenib-induced cell death in liver cancer cells. Role of oxidative and nitrogen reactive species

2021 ◽  
Vol 165 ◽  
pp. 54
Author(s):  
Patricia de la Cruz-Ojeda ◽  
M. Ángeles Rodríguez-Hernández ◽  
Elena Navarro-Villarán ◽  
Paloma Gallego ◽  
Pavla Staňková ◽  
...  
Keyword(s):  
Cell Death ◽  
Liver Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Reactive Species ◽  
Liver Cancer Cells ◽  
Nitrogen Reactive Species
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