scholarly journals Structural and Solubility Parameter Correlations of Gelation Abilities for Dihydroxylated Derivatives of Long-Chain, Naturally Occurring Fatty Acids

2015 ◽  
Vol 21 (23) ◽  
pp. 8530-8543 ◽  
Author(s):  
Mohan Zhang ◽  
Sermadurai Selvakumar ◽  
Xinran Zhang ◽  
Mukund P. Sibi ◽  
Richard G. Weiss
Keyword(s):  
Fatty Acids ◽  
Solubility Parameter ◽  
Naturally Occurring ◽  
Derivatives Of ◽  
Long Chain

Synthesis and spreading behaviour of some reactive derivatives of long-chain alcohols and carboxylic acids

1984 ◽  
Vol 62 (3) ◽  
pp. 574-579 ◽  
Author(s):  
David A. Holden
Keyword(s):  
Mass Spectrometry ◽  
Fatty Acids ◽  
Surface Activity ◽  
Azo Compounds ◽  
Single Chain ◽  
Bulk Solid ◽  
Potential Applications ◽  
Curing Agents ◽  
Derivatives Of ◽  
Long Chain

Procedures are described for the synthesis of several azides, diimides, and azodiformates from long-chain alcohols and fatty acids. These reactive compounds have potential applications as thermal and photochemical curing agents, and as surface-modifying agents for the preparation of filled plastics and chromatographic packings. The surface activity of the compounds was characterized by investigations of their spreading behaviour in monolayers on water. Unlike the single-chain azides and azo compounds, which give well-defined monolayers at all temperatures, monolayers of diacyl diimides and dialkyl azodiformates with two long-chain substituents are unstable with respect to collapse to the bulk solid. The photoreaction of monolayers of octadecanoyl azide to give a mixture of products derived from an intermediate isocyanate was demonstrated by ir and mass spectrometry.

scholarly journals Structural requirements for charged lipid molecules to directly increase or suppress K+ channel activity in smooth muscle cells. Effects of fatty acids, lysophosphatidate, acyl coenzyme A and sphingosine.

1994 ◽  
Vol 103 (3) ◽  
pp. 471-486 ◽  
Author(s):  
S Petrou ◽  
R W Ordway ◽  
J A Hamilton ◽  
J V Walsh ◽  
J J Singer
Keyword(s):  
Fatty Acids ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Coenzyme A ◽  
Muscle Cells ◽  
K Channel ◽  
Channel Activity ◽  
Naturally Occurring ◽  
Acyl Coenzyme A ◽  
Long Chain

We determined the structural features necessary for fatty acids to exert their action on K+ channels of gastric smooth muscle cells. Examination of the effects of a variety of synthetic and naturally occurring lipid compounds on K+ channel activity in cell-attached and excised membrane patches revealed that negatively charged analogs of medium to long chain fatty acids (but not short chain analogs) as well as certain other negatively charged lipids activate the channels. In contrast, positively charged, medium to long chain analogs suppress activity, and neutral analogs are without effect. The key requirements for effective compounds seem to be a sufficiently hydrophobic domain and the presence of a charged group. Furthermore, those negatively charged compounds unable to "flip" across the bilayer are effective only when applied at the cytosolic surface of the membrane, suggesting that the site of fatty acid action is also located there. Finally, because some of the effective compounds, for example, the fatty acids themselves, lysophosphatidate, acyl Coenzyme A, and sphingosine, are naturally occurring substances and can be liberated by agonist-activated or metabolic enzymes, they may act as second messengers targeting ion channels.

Preparation of some long-chain N-acyl derivatives of essential amino acids for nutritional studies

1980 ◽  
Vol 58 (7) ◽  
pp. 573-576 ◽  
Author(s):  
Alenka Paquet
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Physical Properties ◽  
Essential Amino Acids ◽  
Nutritional Studies ◽  
Derivatives Of ◽  
Acyl Derivatives ◽  
Long Chain

Long-chain N-acyl derivatives of methionine, tryptophan, threonine, and lysine (N6) have been obtained by the reaction of succinimidyl esters of fatty acids with the unprotected amino acids. Their physical properties have been characterized.

Combination of long-chain alcohols and fatty acids with alkanes as faecal markers to estimate feed intake and digestibility in horses and cattle fed on grass-heathland vegetation communities

2016 ◽  
Vol 96 (2) ◽  
pp. 221-231 ◽  
Author(s):  
Carlos López López ◽  
Rafael Celaya ◽  
Ana Sofia Santos ◽  
Miguel A.M. Rodrigues ◽  
Koldo Osoro ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Dry Matter ◽  
Diet Composition ◽  
Calluna Vulgaris ◽  
Long Chain Fatty Acids ◽  
Dry Matter Digestibility ◽  
Naturally Occurring ◽  
Heathland Vegetation ◽  
Internal Markers ◽  
Long Chain

Application of long-chain alcohols (LCOH) and long-chain fatty acids (LCFA) combined with alkanes as faecal markers to estimate dry matter intake (DMI) and dry matter digestibility (DMD) of equines and cattle was assessed. Six crossbred mares, randomly divided in two groups (H1 and H2), and three nonlactating cows (C) were housed in individual stalls. Groups H1 and C were fed on a diet of ryegrass (Lolium perenne, 0.7) and heather (Erica spp., Calluna vulgaris, 0.3), and H2 received ryegrass (0.4), heather (0.3) and gorse (Ulex gallii, 0.3). Digestibility was estimated using LCOH (C28-OH and C30-OH) and LCFA (C28-FA, C30-FA, and C32-FA) as internal markers. For DMI estimation, animals received daily a paper pellet containing C24, C32, and C36n-alkanes. Intake was estimated from the faecal ratio of naturally occurring LCOH, LCFA, and dosed n-alkanes, and was compared with the known DMI values. In horses, all markers provided accurate estimates of DMD. Similarly, LCOH provided accurate estimates of DMD in cattle, whereas LCFA underestimated it (P < 0.05). Intake estimates were affected (P < 0.05) by the marker pair used in calculations. In general, the C24:C24-FA pair provided the most accurate DMI estimates. Results suggest the usefulness of combining epicuticular compounds as faecal markers to estimate DMI, DMD and diet composition of horses and cattle grazing grass-heathland communities, simultaneously.

Derivatives of long chain fatty acids as lubricant components

1971 ◽  
Vol 48 (12) ◽  
pp. 811-814 ◽  
Author(s):  
A. Eisner ◽  
T. Perlstein ◽  
G. Maerker ◽  
L. Stallings
Keyword(s):  
Fatty Acids ◽  
Long Chain Fatty Acids ◽  
Derivatives Of ◽  
Long Chain ◽  
Chain Fatty Acids

Ratios for very-long-chain fatty acids in plasma of subjects with peroxisomal disorders, as determined by HPLC and validated by gas chromatography-mass spectrometry.

1988 ◽  
Vol 34 (6) ◽  
pp. 1041-1045 ◽  
Author(s):  
N A Hall ◽  
G W Lynes ◽  
N M Hjelm
Keyword(s):  
Fatty Acids ◽  
Zellweger Syndrome ◽  
Hplc Method ◽  
Gas Chromatography Mass Spectrometry ◽  
Long Chain Fatty Acids ◽  
Peroxisomal Disorders ◽  
One Year ◽  
Derivatives Of ◽  
Long Chain ◽  
Chain Fatty Acids

Abstract We describe an HPLC method for measurement of ratios of concentrations of very-long-chain fatty acids (VLCFA) in plasma. The method, which involves ultraviolet detection of p-bromophenacyl derivatives of fatty acids, is validated by comparison with a gas chromatographic-mass spectrometric (GC-MS) method. The correlation between the ratios of 24-carbon fatty acids to 22-carbon fatty acids (C24/C22) estimated by the two methods was close (r = 0.976) as was the correlation for the C26/C22 ratios (r = 0.947). Increased VLCFA ratios could be demonstrated by either technique in patients with adrenoleukodystrophy, Zellweger syndrome, and infantile Refsum's disease. The HPLC method also measures phytanate concentrations in plasma. Control VLCFA ratios (for subjects without peroxisomal disorders) obtained by the two methods agree well with those reported by Moser et al. (Ann Neurol 1984; 16:628-41). For subjects younger than one year, ratios for C24/C22 and C26/C22 fatty acids were significantly greater than in older subjects.

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