ChemInform Abstract: Catalytic Reaction of Dimethyl Diazomalonate with 2-Mono- and 2,5-Dialkyl(alkenyl)-Substituted Furans.

ChemInform ◽  
1989 ◽  
Vol 20 (22) ◽  
Author(s):  
O. M. NEFEDOV ◽  
A. E. VASIL'VITSKII ◽  
V. L. ZLATKINA ◽  
D. S. YUFIT ◽  
YU. T. STRUCHKOV ◽  
...  
Keyword(s):  
Catalytic Reaction ◽  
Substituted Furans

Protein Flexibility Catalyzes a Cell Signaling Reaction of the Ras-GAP Complex

2019 ◽  
Author(s):  
Keiei Kumon ◽  
Masahiro Higashi ◽  
Shinji Saito ◽  
Shigehiko Hayashi
Keyword(s):  
Cell Signaling ◽  
Conformational Changes ◽  
Catalytic Reaction ◽  
Protein Complex ◽  
Enzyme Mechanism ◽  
Activation Free Energy ◽  
Chemical Catalysis ◽  
Simple Chemical ◽  
A Cell ◽  
Enzyme Molecules

Many enzyme molecules exhibit characteristic global and slow dynamics which furnish them with allostery realizing remarkable molecular functionalities more than simple chemical catalysis. However, molecular mechanism of a catalytic reaction associated with the molecular flexibility of enzymes is not well-understood. Here we report a hybrid molecular simulation study on GTPase activity of a Ras-GAP protein complex for cell signaling termination. We unveiled that extensive conformational changes of the protein complex and exclusion of internal water molecules are induced upon the transition state (TS) formation in the catalytic reaction and significantly lower the reaction activation free energy. We also revealed that tumor-related mutations perturb those conformational changes upon the TS formation, leading to reduction of the catalytic activity. The findings of the remarkably dynamic protein conformation directly linking to the catalytic reaction have broad implications for understanding of enzyme mechanism and for developments of allosteric drugs and novel catalysts.

Silyl substituted furans in the stereoselective Birch reduction

2001 ◽  
Vol 42 (34) ◽  
pp. 5841-5844 ◽  
Author(s):  
Timothy J Donohoe ◽  
Jean-Baptiste Guillermin ◽  
Andrew A Calabrese ◽  
Daryl S Walter
Keyword(s):  
Birch Reduction ◽  
Substituted Furans

scholarly journals Catalytic mechanism of the colistin resistance protein MCR-1

2021 ◽  
Author(s):  
Reynier Suardíaz ◽  
Emily Lythell ◽  
Philip Hinchliffe ◽  
Marc van der Kamp ◽  
James Spencer ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Antimicrobial Resistance ◽  
Dft Calculations ◽  
Catalytic Reaction ◽  
Catalytic Mechanism ◽  
Cluster Models ◽  
Colistin Resistance ◽  
Resistance Protein ◽  
Catalytic Reaction Mechanism

Elucidation of the catalytic reaction mechanism of MCR-1 enzyme, responsible for the antimicrobial resistance to colistin, using DFT calculations on cluster models.

Understanding the Three-way Catalytic Reaction on Pd/CeO2 by Tuning the Chemical State of Pd

2021 ◽  
pp. 149766
Author(s):  
Yenan Liu ◽  
Jing Yang ◽  
Jie Yang ◽  
Li Wang ◽  
Yunsong Wang ◽  
...  
Keyword(s):  
Catalytic Reaction ◽  
Chemical State

scholarly journals Triflic acid promoted solvent free synthesis of densely functionalized furans

RSC Advances ◽  
2017 ◽  
Vol 7 (17) ◽  
pp. 10524-10528 ◽  
Author(s):  
Pulaganti Vijayaprasad ◽  
Avudoddi Venkanna ◽  
Medi Shanker ◽  
Eslavath Kishan ◽  
Pallapothula Venkateswar Rao
Keyword(s):  
Initial Step ◽  
Solvent Free ◽  
Triflic Acid ◽  
Solvent Free Synthesis ◽  
Substituted Furans

A simple, efficient and novel methodology has been developed for the synthesis of substituted furans mediated by triflic acid. In the reaction initial step involves the Friedel–Crafts arylation, followed by the dehydrative cyclization.

scholarly journals Iridium Complex Catalyzed Hydrogen Production from Glucose and Various Monosaccharides

Catalysts ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 891
Author(s):  
Ken-ichi Fujita ◽  
Takayoshi Inoue ◽  
Toshiki Tanaka ◽  
Jaeyoung Jeong ◽  
Shohichi Furukawa ◽  
...  
Keyword(s):  
Hydrogen Production ◽  
Catalytic System ◽  
Catalytic Reaction ◽  
Hydrogen Gas ◽  
Water Soluble ◽  
Starting Material ◽  
Iridium Complex ◽  
Production Of Hydrogen ◽  
Bipyridine Ligand

A new catalytic system has been developed for hydrogen production from various monosaccharides, mainly glucose, as a starting material under reflux conditions in water in the presence of a water-soluble dicationic iridium complex bearing a functional bipyridine ligand. For example, the reaction of D-glucose in water under reflux for 20 h in the presence of [Cp*Ir(6,6′-dihydroxy-2,2′-bipyridine)(H2O)][OTf]2 (1.0 mol %) (Cp*: pentamethylcyclopentadienyl, OTf: trifluoromethanesulfonate) resulted in the production of hydrogen gas in 95% yield. In the present catalytic reaction, it was experimentally suggested that dehydrogenation of the alcoholic moiety at 1-position of glucose proceeded.

scholarly journals Cycloaddition of Thiourea- and Guanidine-Substituted Furans to Dienophiles: A Comparison of the Environmentally-Friendly Methods

2020 ◽  
Vol 3 (1) ◽  
pp. 57
Author(s):  
Luka Barešić ◽  
Davor Margetić ◽  
Zoran Glasovac
Keyword(s):  
High Pressure ◽  
Functional Groups ◽  
Organic Synthesis ◽  
High Speed ◽  
Environmentally Friendly ◽  
Microwave Assisted ◽  
Pressure Synthesis ◽  
Ultrasound Assisted ◽  
Substituted Furans ◽  
Guanidine Moiety

The cycloaddition strategy was employed in order to obtain a 7-oxanorbornene framework substituted with a guanidine moiety or its precursor functional groups: protected amine or thiourea. In order to optimize the conditions for the cycloaddition, several environmentally-friendly methods—microwave assisted organic synthesis, high pressure synthesis, high speed vibrational milling, and ultrasound assisted synthesis—were employed. The outcomes of the cycloaddition reactions were interpreted in terms of endo/exo selectivity, the conversion of the reactants to the product, and the isolated yields. In general, our results indicated the HP and HSVM approaches as the methods of choice to give good yields and conversions.

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